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Can mediate aggregation most likely through a homophilic molecular interaction (By similarity).. Additionally we are shipping ESAM Antibodies (116) and ESAM Kits (12) and many more products for this protein.
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Rat (Rattus) ESAM Protein expressed in Human Cells - ABIN2009359
Hirata Ki, Ishida, Penta, Rezaee, Yang, Wohlgemuth, Quertermous: Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. in The Journal of biological chemistry 2001
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Human ESAM Protein expressed in Human Cells - ABIN2002284
Ishida, Kundu, Yang, Hirata, Ho, Quertermous: Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. in The Journal of biological chemistry 2003
Show all 5 references for ABIN2002284
Mouse (Murine) ESAM Protein expressed in Human Cells - ABIN2008474
Wegmann, Petri, Khandoga, Moser, Khandoga, Volkery, Li, Nasdala, Brandau, Fässler, Butz, Krombach, Vestweber: ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. in The Journal of experimental medicine 2006
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ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias
Serum ESAM is higher in type 2 diabetes mellitus than in controls and parallels oxidative stress.
ESAM regulates tumor metastasis through endothelial cell migration and tube formation in metastatic nodules.
Runx3 (show RUNX3 Proteins) is required for cell identity, homeostasis and function of splenic Esam(high) dendritic cells.
ESAM levels clearly mirror the shift of hematopoietic stem cells (HSC (show FUT1 Proteins)) between quiescence and activation, and the intensity of expression is prominent in comparison with other HSC (show FUT1 Proteins)-related antigens.
ESAM inactivation can reduce susceptibility to atherosclerosis by inhibiting plaque neovascularization and macrophage infiltration into the atheroma.
findings support a model in which ESAM localizes to platelet contacts following platelet activation in order to limit thrombus growth and stability
ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth
The direct interaction between ESAM and MAGI-1 was confirmed by pull-down experiments. The two proteins formed stable complexes in transfected CHO cells.
At endothelial tight junctions ESAM participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts.
ESAM marks hematopoietic stem cells in murine fetal liver and will facilitate studies of hematopoiesis throughout life.
Thus, ESAM may regulate albumin (show ALB Proteins) extravasation at the glomeruli and play a role in the initiation of diabetic nephropathy.
Can mediate aggregation most likely through a homophilic molecular interaction (By similarity).
endothelial cell adhesion molecule
, endothelial cell-selective adhesion molecule
, endothelial cell-specific adhesion molecule
, HUEL (C4orf1)-interacting protein
, LP4791 protein