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ESM1 encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. Additionally we are shipping ESM1 Antibodies (57) and ESM1 Kits (35) and many more products for this protein.
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Human ESM1 Protein expressed in Escherichia coli (E. coli) - ABIN1098721
Bechard, Meignin, Scherpereel, Oudin, Kervoaze, Bertheau, Janin, Tonnel, Lassalle: Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. in Journal of vascular research 2000
Show all 2 references for ABIN1098721
Results reveal a novel pathway for endocan in the control of tumor growth, which involves inflammatory cells of the innate immunity.
Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis.
endocan is normally present in the mouse brain and prior vascular perfusion with FITC may provide a useful tool for identify newly forming blood vessels.
Mouse endocan serum level was measured at a median of 0.96 ng/mL and 1.08 ng/mL in 129Sv mice and C57bl6, respectively.
A paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 (show EDN1 Proteins) acting on the vascular smooth muscle ET(A (show EDNRA Proteins)) receptor.
Results suggest that endocan (ESM-1)is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors.
Suggest that serum endocan concentrations are elevated in patients with type 2 diabetes and decrease following anti-hyperglycemic treatment.
Median maternal plasma endocan concentrations were higher in preeclampsia and lower in acute pyelonephritis with bacteremia than in uncomplicated pregnancy.
Elevated endocan levels were more strongly associated with disease severity among Johnson Syndrome, Toxic Epidermal Necrolysis subjects than among less severe allergic reactions with skin involvement.
Detection of ESM-1 levels in the serum may serve as a tumor biomarker for assessing prognosis in colorectal cancer.
Serum endocan level is independently correlated with the presence and severity of coronary artery disease in hypertension patients.
Serum ESM1 was significantly lower in type 2 diabetes patients than in controls.
higher levels of Endocan-1 were found in maternal plasma in pre-eclamptic group; placental Endocan-1 levels were lower in pre-eclampsia and fetal levels did not show any difference between groups; upregulation of maternal plasma Endocan-1 in the pre-eclamptic group was observed when when stratified in relation to gestational age, systolic blood pressure and proteinuria
Endocan levels are related to endothelial dysfunction in humans in vivo during systemic inflammation evoked by experimental endotoxemia
In bacteremic cases, serum endocan levels in bacteremia tended to be higher than in non-bacteremic cases.
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.
endothelial cell-specific molecule 1
, ESM-1 secretory protein
, pineal specific PG25 protein