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ESM1 encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. Additionally we are shipping ESM1 Antibodies (60) and ESM1 Kits (35) and many more products for this protein.
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Human ESM1 Protein expressed in Escherichia coli (E. coli) - ABIN1098721
Bechard, Meignin, Scherpereel, Oudin, Kervoaze, Bertheau, Janin, Tonnel, Lassalle: Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. in Journal of vascular research 2000
Show all 2 references for ABIN1098721
Results reveal a novel pathway for endocan in the control of tumor growth, which involves inflammatory cells of the innate immunity.
Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability.
This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis.
endocan is normally present in the mouse brain and prior vascular perfusion with FITC may provide a useful tool for identify newly forming blood vessels.
Mouse endocan serum level was measured at a median of 0.96 ng/mL and 1.08 ng/mL in 129Sv mice and C57bl6, respectively.
A paracrine vasoregulatory pathway mediated by endothelial cell-derived ET-1 (show EDN1 Proteins) acting on the vascular smooth muscle ET(A (show EDNRA Proteins)) receptor.
Results suggest that endocan (ESM-1)is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors.
Endocan-expressing microvessel density significantly correlates with the expression of VEGF (show VEGFA Proteins) and VEGFR2 (show KDR Proteins) and is a valuable prognostic factor for survival in human gastric cancer.
Circulating P-selectin (show SELP Proteins) levels were closely associated with endocan levels in obese children and adolescents with non-alcoholic fatty liver disease.
this study shows that endocan may play an important role in the development of connective tissue disease related pulmonary arterial hypertension
The distribution of Gleason score and biochemical failure rate were significantly higher in patients with serum endocan >/=1.8 ng/mL (p = 0.031 and p = 0.047).
endocan plays an anti-carcinogenic role in gastric cancer development and progression and might serve as a prognostic biomarker as well as a potential therapeutic target for gastric cancer.
High ESM1 expression is associated with Meningiomas and Gliomas.
Serum and urinary endocan concentrations are significantly elevated in patients with bladder cancer.
Subclinical hypothyroidism is associated with increased levels of serum endocan, dimethylarginine, and TGF-beta (show TGFB1 Proteins), which are new markers for endothelial dysfunction.
The levels of ESM1, CLDN5 (show CLDN5 Proteins), IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins), and TNF-alpha (show TNF Proteins) were significantly higher in the migraine attack group than in the control group
Results found that serum endocan levels were significantly lower in Alzheimer's disease (AD) patients with depression than in AD patients without depression or healthy controls suggesting that serum endocan levels might be associated with depression in AD.
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for this gene.
endothelial cell-specific molecule 1
, ESM-1 secretory protein
, pineal specific PG25 protein