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Endothelial PAS Domain Protein 1 Proteins (EPAS1)

EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. Additionally we are shipping EPAS1 Antibodies (215) and EPAS1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EPAS1 2034 Q99814
EPAS1 13819 P97481
EPAS1 29452 Q9JHS1
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Top EPAS1 Proteins at antibodies-online.com

Showing 9 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$767.80
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$818.13
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 16 Days
$818.13
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 16 Days
$845.63
Details

EPAS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced EPAS1 Proteins

  1. Human EPAS1 Protein expressed in Wheat germ - ABIN1352871 : Coltella, Percio, Valsecchi, Cuttano, Guarnerio, Ponzoni, Pandolfi, Melillo, Pattini, Bernardi: HIF factors cooperate with PML-RAR? to promote acute promyelocytic leukemia progression and relapse. in EMBO molecular medicine 2014 (PubMed)

More Proteins for Endothelial PAS Domain Protein 1 (EPAS1) Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. Overexpression of EPAS1 is associated with neoplasms.

  2. The expression of both HIF-2alpha and VEGF mRNA did not relate closely to age.

  3. results show that overexpression of HIFs, regardless of whether the HIF-1alpha (show HIF1A Proteins) or HIF-2alpha isoforms are overexpressed is significantly associated with increased risk of mortality in oral squamous cell carcinoma patients

  4. Data indicate that decreased endothelial PAS domain-containing protein 1 (EPAS1) mRNA and increased EPAS1 promoter methylation were detected in chronic obstructive pulmonary disease (COPD (show ARCN1 Proteins)), which were closely associated with increased Toll-Like Receptor 4 (TLR4 (show TLR4 Proteins)) expression.

  5. MicroRNA-383 is a tumor suppressor in human lung cancer by inhibiting EPAS1, both of which could serve as potential therapeutic targets in the treatment of lung cancer.

  6. these data demonstrated that HIF-2alpha could promote hepatocellular carcinoma cell migration by regulating CDCP1 (show CDCP1 Proteins)

  7. both FDG (show SMUG1 Proteins) uptake and HIF-2alpha expression may represent a more aggressive phenotype and that HIF-2alpha may play a more important role than HIF-1alpha (show HIF1A Proteins) in the uptake of FDG (show SMUG1 Proteins) in lung adenocarcinoma

  8. Ovarian endometrioma expresses high levels of HIF-1 (show HIF1A Proteins)/2alpha compared to endometrium from unaffected women.

  9. Abnormal upregulation of HIF-2alpha served as a key switch to direct TSPCs differentiation into osteochondral-lineage rather than teno-lineage. Notably, Scleraxis (Scx), an essential tendon specific transcription factor, was suppressed on constitutive activation of HIF-2alpha and mediated the effect of HIF-2alpha on TSPCs fate decision.

  10. EPAS-1 and PXR (show NR1I2 Proteins) may cooperatively participate in development and especially MDR process of stomach cancer

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (show GCG Proteins) signaling.

  2. demonstrate that HIF-2alpha is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction

  3. Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8 (show SLC39A8 Proteins)-MTF1 (show MTF1 Proteins) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

  4. This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha and HIF-1alpha (show HIF1A Proteins).

  5. genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO (show EPO Proteins) production under conditions of epithelial HIF activation in the kidney.

  6. Chondrocytes co-cultured with HIF-2alpha-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 (show MMP3 Proteins) and Mmp13 (show MMP13 Proteins), which is similar to the effects induced by interleukin (IL)-6 (show IL6 Proteins) treatment of chondrocytes.

  7. HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.

  8. HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Proteins)) and a dysfunctional thermogenic response to cold exposure.

  9. Loss of Hif-2alpha Rescues the Hif-1alpha (show HIF1A Proteins) Deletion Phenotype of Neonatal Respiratory Distress In Mice

  10. although Hif-1alpha (show HIF1A Proteins) and Hif-2alpha synergize to suppress the development of acute myeloid leukemia (show BCL11A Proteins), they are not required for leukemic stem cells maintenance.

Pig (Porcine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. immunostaining for HIF-1alpha (show HIF1A Proteins) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification

Cow (Bovine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.

EPAS1 Protein Profile

Protein Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

Gene names and symbols associated with EPAS1

  • endothelial PAS domain protein 1 (EPAS1)
  • endothelial PAS domain protein 1 (epas1)
  • endothelial PAS domain protein 1 (Epas1)
  • bhlhe73 protein
  • ecyt4 protein
  • EPAS protein
  • EPAS-1 protein
  • EPAS1 protein
  • HIF-2alpha protein
  • hif2 protein
  • hif2a protein
  • hif2alpha protein
  • hlf protein
  • HRF protein
  • mop2 protein
  • pasd2 protein

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

GENE ID SPECIES
459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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