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The protein encoded by EDN1 is proteolytically processed to release a secreted peptide termed endothelin 1. Additionally we are shipping Endothelin 1 Kits (89) and Endothelin 1 Proteins (19) and many more products for this protein.
Showing 10 out of 265 products:
Cow (Bovine) Polyclonal Endothelin 1 Primary Antibody for IHC, ELISA - ABIN1582246
Jo, Ryu, Kim, Yeo, Kim, Choi, Song, Kang: Up-regulation of endothelial endothelin-1 expression prior to vasogenic edema formation in the rat piriform cortex following status epilepticus. in Neuroscience letters 2011
Show all 3 references for ABIN1582246
Dog (Canine) Monoclonal Endothelin 1 Primary Antibody for ICC, FACS - ABIN152685
Talati, West, Blackwell, Loyd, Meyrick: BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. in American journal of physiology. Lung cellular and molecular physiology 2010
Show all 2 references for ABIN152685
Human Polyclonal Endothelin 1 Primary Antibody for EIA, FACS - ABIN952083
Gonsalves, Kalra: Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Polyclonal Endothelin 1 Primary Antibody for EIA, IF - ABIN952084
Kaparianos, Argyropoulou, Efremidis, Flordellis, Spiropoulos: Decline in FEV1 related to genetic polymorphisms (+138insA/delA and Lys198Asn) of the endothelin-1 gene in COPD. A pilot study. in European review for medical and pharmacological sciences 2010
Show all 2 references for ABIN952084
Human Polyclonal Endothelin 1 Primary Antibody for EIA, IHC (fro) - ABIN191753
Ergün, Harneit, Paust, Mukhopadhyay, Holstein: Endothelin and endothelin receptors A and B in the human testis. in Anatomy and embryology 1999
Mouse (Murine) Polyclonal Endothelin 1 Primary Antibody for IHC, WB - ABIN3021076
Swigris, Brown: The role of endothelin-1 in the pathogenesis of idiopathic pulmonary fibrosis. in BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2010
Human Monoclonal Endothelin 1 Primary Antibody for IHC (fro), RIA - ABIN110809
Yao, Morioka, Li, Oite: Endothelin is a potent inhibitor of matrix metalloproteinase-2 secretion and activation in rat mesangial cells. in American journal of physiology. Renal physiology 2001
Phylogenetic analysis of conserved grhl (show GHRL Antibodies)-binding sites in gene regulatory regions identified endothelin-1 (edn1) as a putative direct grhl3 (show GRHL3 Antibodies) target gene, and this was confirmed by chromatin precipitation assays in embryos.
EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.
Data suggest that edn1/ednraa (show EDNRA Antibodies) (endothelin-1/endothelin-1 receptor type A (show EDNRA Antibodies)) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase (show DNAH8 Antibodies) in zebrafish embryonic skin.
These findings point to complexity of regulation by edn1 and hand2 at the earliest stages of pharyngeal arch development, in which control of growth and morphogenesis can be genetically separated.
Endothelin 1 combines with Bone Morphogenetic Proteins to pattern the dorsal-ventral axis of the craniofacial skeleton.
activation of Endothelin-1 signaling in craniofacial patterning
Edn1 from the pharyngeal ectoderm signals through Ednra (show EDNRA Antibodies) proteins to direct early dorsoventral patterning of the skeletogenic neural crest.
The role of endothelin-1 and light in the regulation of melanopsins and the clock proteins in an embyronic cell line is reported.
This is the first report describing the cDNA encoding preproendothelin-1 in an amphibian species.
A new role for et-1 signaling during early neural crest specification is reported.
Serum and synovial fluid endothelin-1 concentrations are correlated with the development and progression of knee osteoarthritis.
This study demonstrated the pathogenesis mechanism during the development of dementia after ischemic stroke by investigating the relationship between miR (show MLXIP Antibodies)-125a and its target ET-1.
Urinary TGF-beta1 (show TGFB1 Antibodies) and ET-1 levels were associated with AGT (show AGXT Antibodies) level, which likely reflects an early interplay between tissue remodeling and RAAS in obesity-related kidney injury.
High circulating endothelin-1 levels are associated with the development of impaired glucose tolerance and type 2 diabetes in women.
Serum endothelin-1 was elevated in preeclampsia and correlated with severity of illness.
There was no significant difference in serum EDN1 between patients with vasovagal syncope, epilepsy, and controls.
Therefore, despite a clear age-specific role in the regulation of vascular tone, endogenous ET-1, acting through endothelin type A receptors, does not account for the age-related reduction in mean shear rate in the common femoral artery.
In patients with autosomal dominant polycystic kidney disease, urinary ET-1 was inversely associated with eGFR (show EGFR Antibodies) and positively correlated with total kidney volume.
Congenital heart disease complicated with pulmonary artery hypertension is associated with increased circulating endothelial cell counts and ET-1 production.
demonstration that pericardial fluid (PF) of cardiac patients elicit substantial arterial constrictions, which is mediated primarily by ET-1; interfering with the vasoconstrictor action of PF could be a potential therapeutic target to improve coronary blood flow in cardiac patients
sub-vasomotor concentration of ET-1 leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Antibodies) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Antibodies) following ETA receptor activation
ET1 was lowest in kidneys removed from live pigs, greater in kidneys from pigs with brain death, and greatest in kidneys from pigs with cardiac arrest.
ET-1 contributes to formation of oedema during experimental sepsis by a novel mechanism involving increased HBP (show HEBP1 Antibodies) release from neutrophils.
Endothelin-1 expression is upregulated following therapeutic hypothermia after cardiac arrest.
ET-1 produces contraction of the urinary bladder neck muscles via muscular ET(A (show EDNRA Antibodies)) receptors coupled to extracellular Ca(2 (show CA2 Antibodies)+) entry via VOC (L-type) and non-VOC channels.
Endothelin-1 elevation is not only a conserved phenomenon in a pig traumatic brain injury (TBI) model, but it is a likely target for understanding the observed enhanced vascular response to TBI.
interleukin-6 (show IL6 Antibodies), endothelin ET-1, and apoptotic Bak (show BAK1 Antibodies) and Bcl-XL (show BCL2L1 Antibodies) genes have roles in small bowel transplantation, in a swine model of ischemia and reperfusion injury
ET-1 elicits a different pattern of Src (show SRC Antibodies) family kinase (SFK) activation and might trigger a different pattern of SFK activation from that caused by ATP and UTP.
Compared with the untreated group, the levels of serum ET-1 after acute myocardial infarction and reperfusion were significantly decreased in the Xuefu Zhuyu-treated group.
study suggests a possible role for endothelin-1(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Antibodies)) acting via endothelin receptor A (show EDNRA Antibodies) in the control of luteolytic sensitivity in the pig
We demonstrated that (i) treatment of bovine pulmonary artery smooth muscle cells with ET-1 stimulates cPLA2 (show PLA2G4A Antibodies) activity in the cell membrane.
Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS (show NOS Antibodies) in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.
Oxidized LDL is a stimulus of ET-1 production in cultured vascular endothelial cells.
Endothelin-1 decreases ethanolamine plasmalogen levels and evokes platelet-activating factor production in brain microvessels
prostaglandin F2alpha, endothelin-1, and angiotensin II may interact with each other in a local positive feedback manner to activate their secretion in the regressing corpus luteum, thus accelerating and completing luteolysis
LOX-1 (show OLR1 Antibodies) and CD40 (show CD40 Antibodies) synergistically, but through a distinct pathway, work to induce endothelin-1 expression in endothelial cells.
Elevated local expression of ET-1 and Ednra/Ednrb (show EDNRB Antibodies) during the peri (show PLIN1 Antibodies)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.
Suggest that the activation of a local positive feedback mechanism in the corpus luteum among ET-1, Ang II (show AGT Antibodies) and PGF2alpha might play a functional role in the paracrine modulation of luteolytic cascade.
The combined metabolic burden of homocysteine and high glucose stimulates ET-1 synthesis in bovine aortic endothelial cells via a mechanism dependent on the production of mitochondrial ROS (show ROS1 Antibodies), but may not be generalisable to all types of endothelial cells.
hypoxia and endothelin-1 have roles in mediating vasa (show DDX4 Antibodies) vasorum neovascularization with pulmonary artery adventitial fibroblasts
AMPAR-mediated glutamatergic neurotransmission may underlie the mechanism of ET1-ET(A (show EDNRA Antibodies))R signaling pathway in the regulation of anxiety.
indicate that endothelin-1 is critical in the development of cerebrovascular and cognitive impairments with experimental cerebral malaria
increased extrarenal vascular ET-1 production in response to HS intake is mediated by increased extracellular osmolarity and plays a critical role in regulating skin storage of Na(+)
PPARgamma (show PPARG Antibodies) regulates miR (show MLXIP Antibodies)-98 to modulate ET-1 expression and pulmonary endothelial cell proliferation in pulmonary hypertension.
these results indicated that I/R induced upregulation of ET1 and ETA in the kidneys, which was, at least in part, dependent on the production of inflammatory cytokines.
we have demonstrated that the expression of ET-1 and IL-25 (show IL25 Antibodies) was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model.
The cardiac expression of prepro-endothelin-1 mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight. Furthermore, endothelin-1 plasma levels showed an increasing trend.
This study showed a novel SIRT1 (show SIRT1 Antibodies) mediated protection against renal and retinal injury in diabetes, regulated through p300 (show NOTCH1 Antibodies), ET-1 and TGF-beta1 (show TGFB1 Antibodies).
these results mechanistically link the innate immune response mediated by IkappaBbeta (show NFKBIB Antibodies)/NF-kappaB (show NFKB1 Antibodies) to ET-1 expression and potentially reveal therapeutic targets for patients with Gram-negative septic shock.
ET-1 overexpressing astrocytic cells showed amyloid secretion after hypoxia/ischemia insult suggests a role of astrocytic ET-1 in dementia associated with stroke by astrocyte-derived amyloid production
Short-term hyperinsulinaemia leads to increased vascular resistance in the equine digit and increased expression of ET-1 in the laminar tissue.
Dynamic monitoring and comparison of plasma levels of ET, CGRP, NO, and MDA as well as SOD activity revealed that appropriate intervention of these factors may reduce reperfusion injury
In a saline lavage-induced lung injury model, both circulatory and pulmonary ET-1 levels increased.
Data suggest elevated levels of endothelin-1, as exhibited in cardiovascular diseases, facilitate development of ventricular arrhythmia by steepening action potential duration restitution and by increasing beat-to-beat variability of repolarization.
High levels of ET-1 are closely associated with BBB (show ALMS1 Antibodies) disruption. ET-1 may play an important role in the pathogenesis of secondary brain injury after ICH (show ACE Antibodies).
After subarachnoid hemorrhage, the contractile response to ET-1 was enhanced, and the ET(A (show EDNRA Antibodies)) receptor expression was upregulated in the basilar artery.
After acute pulmonary thromboembolism, thrombolytic and anti-inflammatory treatment could decrease acute lung injury induced by ET-1 and NF-kappaB (show NFKB1 Antibodies) activation. [endothelin-1; NFKB]
The increase in myocardial distensibility induced by endothelin-1 is absent in heart failure and is dependent on nitric oxide and prostaglandin release.
Endothelin-1 enhances nuclear Ca2 (show CA2 Antibodies)+ transients in atrial myocytes through Ins (show INS Antibodies)(1,4,5)P3-dependent Ca2 (show CA2 Antibodies)+ release from perinuclear Ca2 (show CA2 Antibodies)+ stores
The enhancement of gap junction intercellular communication is activated by endothelin-1 via modulating the expression of connexin43 (show GJA1 Antibodies), and plays an important role in the pathogenesis of cerebral vasospasm
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
, endothelin 1
, gene for endothelin
, preproendothelin 1