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Endothelin 2 Proteins (EDN2)

EDN2 encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. Additionally we are shipping Endothelin 2 Antibodies (64) and Endothelin 2 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EDN2 1907 P20800
Mouse EDN2 EDN2 13615 P22389
Rat EDN2 EDN2 24324 P23943
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Top Endothelin 2 Proteins at

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 11 to 13 Days
HOST_Human Human Un-conjugated   1 mg Log in to see 6 to 11 Days
Human Un-conjugated   1 mg Log in to see 6 Days

EDN2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,

Top referenced Endothelin 2 Proteins

  1. Human Endothelin 2 Protein expressed in Escherichia coli (E. coli) - ABIN1098787 : Bourgeois, Robert, Rebourcet, Mondon, Mignot, Duc-Goiran, Ferré: Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3. in The Journal of clinical endocrinology and metabolism 1997 (PubMed)
    Show all 2 references for ABIN1098787

More Proteins for Endothelin 2 (EDN2) Interaction Partners

Pig (Porcine) Endothelin 2 (EDN2) interaction partners

  1. Report the molecular cloning and sequence analysis of the porcine precursor of endothelin-2.

Human Endothelin 2 (EDN2) interaction partners

  1. EDN2 expression in left internal mammary arteries depends on tissue harvesting technique.

  2. Overexpression of Edn2 in the mouse retina causes an excess of tip cells and inhibits vascular growth. Overexpression of Edn2 in the brain and skin had no effect, but vascular development was inhibited in midgestation mouse embryos.

  3. Endothelin 2 and endothelin receptor type B (show EDNRB Proteins) may be a regenerative pathway for central nervous system myelination and remyelination.

  4. Studies revealed hypermethylation of EDN2 and EDN3 (show EDN3 Proteins) genes in human primary colon cancers and in a panel of human colon cancer cell lines. Epigenetic inactivation of ET-2 and ET-3 (show EDN3 Proteins) occurs frequently in both rat and human colon cancers.

  5. plasma levels of big ET-2, and big ET-3 (show EDN3 Proteins) are markedly increased in patients with end stage renal disease on hemodialysis

  6. In granulosa lutein cells from women with polycystic ovary syndrome, endothelin-2 mRNA was reduced as compared with normally ovulating women

  7. although endothelin 2 does not appear to be an independent prognostic marker, there is evidence of a putative role in clear cell renal cell carcinoma (show MOK Proteins) progression

  8. EDN3 (show EDN3 Proteins), in contrast to EDN1 (show EDN1 Proteins) and EDN2, may act as natural tumour suppressor in the human mammary gland

  9. Endothelin-2 is a macrophage chemoattractant. ET-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.

  10. Endothelin-2 is a hypoxia-induced autocrine survival factor for breast tumor cells

Mouse (Murine) Endothelin 2 (EDN2) interaction partners

  1. EDN2 is necessary for normal ovulation and corpus luteum formation.

  2. Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.

  3. Edn2-mediated mechanisms that contribute to PR survival

  4. ET-2 is critical for the growth and survival of postnatal mice and plays important roles in energy homeostasis, thermoregulation, and the maintenance of lung morphology and function.

  5. We conclude that constitutive overexpression of Norrin (show NDP Proteins) protects photoreceptors from light damage, an effect that is mediated by Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and EDN2 signaling and involves neurotrophic activities of BDNF (show BDNF Proteins).

  6. ET-2 acts in a cooperative manner with ET-1 (show EDN1 Proteins), giving to the villus the straight enough to withstand mechanical stress.

  7. Since endothelin 2 is potently vasoconstrictive and was produced by microglia/macrophages, our data provide what we believe to be a novel link between these cell types and vascular dysfunction in glaucoma.

  8. These data indicate that ET-2 is a direct target gene of Hedgehog (show SHH Proteins) signaling in basal cell carcinoma.

  9. ET-2 gene expression gradually increases after parturition

  10. expression profile & localization in the intestinal tract; results suggest that in intestinal epithelial cells ET-2 could be secreted into the lamina propria & dome region in Peyer's patch & that it might modulate immune cells for mucosal defense

Horse (Equine) Endothelin 2 (EDN2) interaction partners

  1. Report cDNA cloning, sequence analysis and organ distribution of horse preproendothelin-2.

Endothelin 2 (EDN2) Protein Profile

Protein Summary

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.

Gene names and symbols associated with Endothelin 2 Proteins (EDN2)

  • endothelin 2 (EDN2)
  • endothelin 2 (edn2)
  • endothelin 2 (Edn2)
  • preproendothelin-2 (PPET2)
  • EDN2 protein
  • endothelin-2 protein
  • ET-2 protein
  • Et2 protein
  • PPET2 protein
  • si:ch211-202b2.2 protein
  • VIC protein

Protein level used designations for Endothelin 2 Proteins (EDN2)

endothelin-2 , endothelin 2 , ET-2 , preproendothelin 2 , preproendothelin-2 , PPET2 , vasoactive intestinal contractor peptide , Endothelin isopeptide 2 , RNEDN2S01 , VIC , vasoactive intestinal contractor

419559 Gallus gallus
469298 Pan troglodytes
569550 Danio rerio
695960 Macaca mulatta
100286879 Sus scrofa
1907 Homo sapiens
13615 Mus musculus
24324 Rattus norvegicus
319094 Bos taurus
494215 Felis catus
403508 Canis lupus familiaris
100033847 Equus caballus
100008634 Oryctolagus cuniculus
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