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Endothelin-converting enzymes, such as ECE2 (EC 184.108.40.206), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001 [PubMed 11718899]).[supplied by OMIM, Mar 2008].. Additionally we are shipping ECE2 Proteins (10) and ECE2 Kits (3) and many more products for this protein.
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Human Polyclonal ECE2 Primary Antibody for WB - ABIN1881279
Lorenzo, Khan, Wang, Tai, Chan, Cheung, Marsden: Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. in Biochimica et biophysica acta 2001
Show all 4 references for ABIN1881279
Human Polyclonal ECE2 Primary Antibody for IF (p), IHC (p) - ABIN733958
Esposito, Sarnelli, Capoccia, Cirillo, Pesce, Lu, Calì, Cuomo, Steardo: Autologous transplantation of intestine-isolated glia cells improves neuropathology and restores cognitive deficits in β amyloid-induced neurodegeneration. in Scientific reports 2016
Te results of this study suggested taht genetic variations in MMEL1 (show MMEL1 Antibodies), ECE1 (show ECE1 Antibodies), ECE2, AGER (show AGER Antibodies), PLG (show PLG Antibodies), PLAT (show PLAT Antibodies), NR1H3 (show NR1H3 Antibodies), MMP3 (show MMP3 Antibodies), LRP1 (show LRP1 Antibodies), TTR (show TTR Antibodies), NR1H2 (show NR1H2 Antibodies), and MMP9 (show MMP9 Antibodies) genes do not play major role among the Finnish AD patient cohort.
The PL405 assay is thus the first tool to study ECE-2 inhibition using high throughput screening or for ex vivo ECE-2 quantification.
Data show that CD133 and ECE (show ECE1 Antibodies) expressions are associated with lymphoid metastasis and prognosis of NSCLC, and their overexpression often suggests unfavorable prognosis of NSCLC.
The most significantly downregulated gene in this data set was the endothelin converting enzyme 2 (ECE2), implicated in amyloid beta clearance.
An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene
Abeta (show APP Antibodies) accumulation in Alzheimer's disease is unlikely to be caused by ECE-2 deficiency. However, ECE-2 expression is up-regulated
These results suggest that ECE2, by selectively processing endogenous opioid peptides in the endocytic compartment, plays a role in modulating opioid receptor activity
a role for differential modulation of opioid receptor signaling by post-endocytic processing of peptide agonists by ECE2.
ECE-2 has a role in the non-classical processing of spinal cord peptides and morphine responses, including the cleavage of a number of neuropeptides at non-classical sites in vitro.
deficits in learning and memory in ECE2 knockout mice may provide unique insights into processes that may contribute to this disease and possible other disorders of cognition
novel four subisoforms of ECE-2 that differ in their N-terminal cytoplasmic tails
ECE2 has a role in limiting Abeta (show APP Antibodies) accumulation in the mouse brain
Data suggest that, in Fallopian tubes, endothelins (EDN1 (show EDN1 Antibodies), EDN2 (show EDN2 Antibodies), EDN3 (show EDN3 Antibodies)) and EDN (show RNASE2 Antibodies)-converting enzymes (ECE1 (show ECE1 Antibodies), ECE2) are expressed in epithelial cells; EDN (show RNASE2 Antibodies) receptors (EDNRA (show EDNRA Antibodies), EDNRB (show EDNRB Antibodies)) are present in smooth-muscle. Expression of EDN1 (show EDN1 Antibodies), EDN2 (show EDN2 Antibodies), and ECE2 is highest on day of ovulation. EDN (show RNASE2 Antibodies)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.
Endothelin-converting enzymes, such as ECE2 (EC 220.127.116.11), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001
endothelin converting enzyme 2
, endothelin-converting enzyme 2
, endothelin-converting enzyme 2 isoform 2a-1
, endothelin-converting enzyme 2 isoform 2a-2
, endothelin-converting enzyme 2 isoform 2b-1
, endothelin-converting enzyme 2 isoform 2b-2