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Endothelin Receptor Type B Proteins (EDNRB)

The protein encoded by EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Additionally we are shipping EDNRB Antibodies (96) and EDNRB Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EDNRB 1910 P24530
Rat EDNRB EDNRB 50672 P21451
EDNRB 13618 P48302
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Top EDNRB Proteins at

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 0.5 mg Log in to see 49 to 54 Days
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

EDNRB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

More Proteins for Endothelin Receptor Type B (EDNRB) Interaction Partners

Human Endothelin Receptor Type B (EDNRB) interaction partners

  1. EDNRB plays a key role in hypoxia tolerance

  2. The increased gene expression of MITF (show MITF Proteins) and EDNRB in UVB-exposed NHMs.

  3. culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB

  4. Polymorphisms of the EDNRB gene may influence the susceptibility to obesity and can interact with plasma arsenic levels

  5. Cumulative effects of the RET (show RET Proteins) and EDNRB genes contribute to long-segment and total colonic aganglionosis.

  6. Endothelin receptor B expression was significantly lower while higher staining grade was found in basal cell carcinoma rather than squamous cell carcinoma or psoriasis.

  7. The aim was to quantify the density of ETA and ETB receptors in cardiopulmonary tissue from pulmonary arterial hypertension patients and the monocrotaline (MCT (show MCAT Proteins)) rat.

  8. effect of SNP polymorphisms of EDN1 (show EDN1 Proteins), EDNRA (show EDNRA Proteins), and EDNRB gene on ischemic stroke

  9. The results show that MitA (show TMEM173 Proteins) can effectively be used to block ETBR mediated vasoconstriction as a supplement to an existing ischemic stroke therapy.

  10. Identification of heterozygous deletion of the entire EDNRB in a father and 2 children. Since heterozygous deletion was the only change identified in EDNRB, the family represents one of the few cases of autosomal dominant inheritance of Waardenburg type 4

Mouse (Murine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. we show that ET-1 (show EDN1 Proteins) acts selectively through EDNRB on astrocytes-and not oligodendrocyte progenitor cells-to indirectly inhibit remyelination.

  2. EDNRB plays a key role in hypoxia tolerance

  3. The cardiac expression of prepro-endothelin-1 (show EDN1 Proteins) mRNA, endothelin-converting enzyme-1 (show ECEL1 Proteins) mRNA, and protein and endothelin receptors A and B mRNA was increased in 18-week-old obese C57BL/6 mice compared to animals with normal weight

  4. results indicate that the Notch1 (show NOTCH1 Proteins)-STAT3 (show STAT3 Proteins)-ETB(R) axis connects a signaling network that promotes reactive astrocyte proliferation after brain injury

  5. Ednrb-deficient mice showed altered goblet cell differentiation and surface mucus properties characteristic of human Hirschsprung disease.

  6. pathophysiological events in the brain in sepsis mediated by ET-1 (show EDN1 Proteins)/ETB receptor axis, were evaluated.

  7. PROD (show TAF8 Proteins)-rol/rol mice with classic piebald mutation have two mutant genes, Ednrb and Cacna1a (show CACNA1A Proteins).

  8. Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3 (show EDN3 Proteins)-null mouse models of Hirschsprung-associated enterocolitis.

  9. ednrb expression in the heart was restricted to the endocardium and coronary endothelium

  10. Podocyte endothelin type B receptors significantly contribute to diabetes-induced activation of the beta-catenin (show CTNNB1 Proteins) cascade.

Pig (Porcine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.

  2. ET(A (show EDNRA Proteins))/ET(B) blockade decreased pulmonary vascular resistance but only during exercise.

  3. endothelial endothelin ET(B) receptors induce NO and EDHF mediated vasodilatation in porcine coronary arteries; in organ culture, endothelial endothelin ET(B) receptors are down-regulated

  4. PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries

  5. extracellular ET-1 (show EDN1 Proteins) regulates the abundance of ET-1 (show EDN1 Proteins) mRNA in PAECs, in an ETB receptor-dependent manner, by modulating both mRNA stability and transcription via mechanisms involving receptor endocytosis and both ERK (show MAPK1 Proteins) and p38 MAPK (show MAPK14 Proteins) pathways

Cow (Bovine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  2. Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

Horse (Equine) Endothelin Receptor Type B (EDNRB) interaction partners

  1. Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR (show EDNRA Proteins) antagonists might be beneficial for treatment of laminitis in horses.

  2. both ETA and ETB receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins

Rabbit Endothelin Receptor Type B (EDNRB) interaction partners

  1. Stimulation of ETA and ETB receptors activates native protein kinase C-dependent transient receptor potential channel (TRPC)1 through phospholipid pathways involving phosphoinositol-3,4,5-trisphosphate (PIP)3 and PIP2 in coronary artery myocytes.

  2. ET(B) receptor stimulation relaxes the carbachol precontracted iris sphincter muscle, an effect that is mediated by the ET(B2) receptor subtype, through NO and the release of prostaglandins.

EDNRB Protein Profile

Protein Summary

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EDNRB

  • endothelin receptor type B (EDNRB)
  • endothelin receptor type B (ednrb)
  • endothelin receptor B subtype 2 (ednrb2)
  • endothelin receptor type B (Ednrb)
  • ABCDS protein
  • Ednra protein
  • ednrb protein
  • ET-B protein
  • ET-BR protein
  • ETb protein
  • ETBR protein
  • ETR-b protein
  • ETRB protein
  • HSCR protein
  • HSCR2 protein
  • Sox10m1 protein
  • WS4A protein

Protein level used designations for EDNRB

endothelin receptor type B , endothelin B receptor , endothelin receptor B , endothelin-B receptor , endothelin receptor non-selective type , ET-B , ET-BR , piebald , endothelin receptor subtype B , endothelin ETB receptor

408082 Gallus gallus
403725 Canis lupus familiaris
452613 Pan troglodytes
697329 Macaca mulatta
779931 Xenopus (Silurana) tropicalis
780133 Xenopus (Silurana) tropicalis
1910 Homo sapiens
50672 Rattus norvegicus
13618 Mus musculus
403862 Canis lupus familiaris
414911 Sus scrofa
281750 Bos taurus
100033875 Equus caballus
100009477 Oryctolagus cuniculus
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