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ELMO1 encodes a member of the engulfment and cell motility protein family. Additionally we are shipping ELMO1 Antibodies (70) and ELMO1 Proteins (7) and many more products for this protein.
ELMO-DOCK1 (show DOCK1 ELISA Kits), a bipartite guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) complex for the small GTPase (show RACGAP1 ELISA Kits) Rac1, and for the membrane-cytoskeletal linker Ezrin (show EZR ELISA Kits), regulates centriole/basal body migration, docking and spacing.
A significant association of the SLC12A3 (show SLC12A3 ELISA Kits) rs11643718 and ELMO1 rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.
Cdc27 (show CDC27 ELISA Kits) is a novel binding partner of Elmo1.Cdc27 (show CDC27 ELISA Kits)-Elmo1 has a cellular role independent from the Elmo-Dock1 (show DOCK1 ELISA Kits)-Rac (show AKT1 ELISA Kits) signal module.
ELMO1 is expressed in rheumatoid arthritis synovium, promotes cell migration and invasion, and regulates Rac1 activity, thereby mediating rheumatoid arthritis pathogenicity.
Src-mediated Y724 phosphorylation in ELMO1 plays a critical role for cell spreading via activation of Rac1, leading to promotion of cell migration.
high ELMO1 expression is an independent negative prognostic factor in normal karyotype (NK) acute myeloid leukemia (show BCL11A ELISA Kits).
For ELMO1 (+9170 G>A), the GG genotype frequency was higher in the diabetic versus control group, but there were no differences between diabetic patients with and without nephropathies.
Thus, Elmo1 and Dock180 (show DOCK1 ELISA Kits) facilitate blood vessel formation by stabilization of the endothelium during angiogenesis.
There is a low frequency rate of the ancestral genotype for the ELMO1 polymorphism rs1345365 in mestizos from the western and southeastern regions of Mexico.
High ELMO1 expression is associated with serous ovarian cancer.
the present study characterized a novel Nck-1-ELMO1 interaction and defined a new role for Nck-1 in regulating Rac1 activity.
The authors identify ELMO1 as a novel target of TGFbeta (show TGFB1 ELISA Kits) signaling and show that restoration of Tgfbr2 (show TGFBR2 ELISA Kits) results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2 (show TGFBR2 ELISA Kits)-deficient invasive transition zone squamous cell carcinoma.
Elmo1 hypermorphs have albuminuria, glomerulosclerosis, and changes in the ultrastructure of the glomerular basement membrane that increase in severity in parallel with the expression of Elmo 1.
Src contributed to tyrosine phosphorylation of ELMO1 at Y720 and Y724 residues, which was crucial for activation of Rac1, followed by the promoting cell adhesion, spreading, and migration.
findings reveal a previously unknown, nonredundant role for Elmo1 in controlling Dock2 (show DOCK2 ELISA Kits) levels and Dock2 (show DOCK2 ELISA Kits)-dependent T cell migration in primary lymphocytes.
regulator of Med31 (show MED31 ELISA Kits), revealing a previously unrecognized link between cytoplasmic signaling proteins and the Mediator complex
Data show that intracellular engulfment protein ELMO1 was required for phagocytosis by DCX (show DCX ELISA Kits)(+) cells.
findings uncover a selective requirement for ELMO1 in Sertoli-cell-mediated removal of apoptotic germ cells and make a compelling case for a relationship between engulfment and tissue homeostasis in vivo
functional studies suggest that BAI1 (show BAI1 ELISA Kits) cooperates with ELMO/Dock180 (show DOCK1 ELISA Kits)/Rac (show AKT1 ELISA Kits) to promote maximal engulfment of apoptotic cells
A novel signaling cascade is identified in which ELMO1/DOCK180 (show DOCK1 ELISA Kits) regulates vasculature formation in zebrafish.
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein ced-12-like protein
, engulfment and cell motility protein 1
, engulfment and cell motility 1
, engulfment and cell motility protein 1-like
, ced-12 homolog 1
, engulfment and cell motility 1, ced-12 homolog
, engulfment and cell motility 1 splice 1