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In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity). Additionally we are shipping EDC4 Antibodies (33) and EDC4 Kits (3) and many more products for this protein.
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Seedling lethal phenotypes in dcp1 (show ACE Proteins), dcp2 (show DCP2 Proteins) and vcs mutants are caused the disruption of miRNA-mediated gene regulation.
DCP2 (show DCP2 Proteins) interacts in vitro and in vivo with DCP1 (show ACE Proteins) and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1, suggesting that the three proteins operate as a decapping complex.
The assembly of EDC4 and Dcp1a (show DCP1A Proteins) into processing bodies is critical for the translational regulation of IL-6 (show IL6 Proteins).
LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L (show IFI44L Proteins).
EDC4 is a processing body (P-body) component.
The data indicates that DCP2 activation by DCP1 occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5'-to-3' mRNA degradation by XRN1 in human cells.
EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
Ge-1, the human ortholog of mouse Edc4, was shown to localize to mRNA processing bodies (P-body)in a human cell line. The C-terminal region is required for this localization.
The human Ge-1 gene (also known as Hedls and Edc4)is an ortholog of mouse Edc4. The gene was identified by screening a cDNA expression library using serum from a patient with Sjogren's syndrome.
In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity).
enhancer of mRNA decapping 4
, autoantigen Ge-1
, autoantigen RCD-8
, enhancer of mRNA-decapping protein 4
, human enhancer of decapping large subunit
, autoantigen RCD8