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In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity). Additionally we are shipping EDC4 Antibodies (34) and EDC4 Proteins (3) and many more products for this protein.
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Data suggest that specific motifs, secondary energy, and GC content of transcripts could play a role in their degradation by exoribonuclease4 (xrn4) and varicose (vcs).
Seedling lethal phenotypes in dcp1 (show ACE ELISA Kits), dcp2 (show DCP2 ELISA Kits) and vcs mutants are caused the disruption of miRNA-mediated gene regulation.
DCP2 (show DCP2 ELISA Kits) interacts in vitro and in vivo with DCP1 (show ACE ELISA Kits) and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1, suggesting that the three proteins operate as a decapping complex.
The assembly of EDC4 and Dcp1a (show DCP1A ELISA Kits) into processing bodies is critical for the translational regulation of IL-6 (show IL6 ELISA Kits).
LMKB is the first protein identified to date that interacts with this portion of Ge-1. LMKB was expressed in human B and T lymphocyte cell lines; depletion of LMKB increased expression of IFI44L.
EDC4 is a processing body (P-body) component.
The data indicates that DCP2 (show DCP2 ELISA Kits) activation by DCP1 (show ACE ELISA Kits) occurs preferentially on the EDC4 scaffold, which may serve to couple DCP2 (show DCP2 ELISA Kits) activation by DCP1 (show ACE ELISA Kits) with 5'-to-3' mRNA degradation by XRN1 (show XRN1 ELISA Kits) in human cells.
EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies
Ge-1, the human ortholog of mouse Edc4, was shown to localize to mRNA processing bodies (P-body)in a human cell line. The C-terminal region is required for this localization.
The human Ge-1 gene (also known as Hedls and Edc4)is an ortholog of mouse Edc4. The gene was identified by screening a cDNA expression library using serum from a patient with Sjogren's syndrome.
In the process of mRNA degradation, seems to play a role in mRNA decapping (By similarity).
enhancer of mRNA decapping 4
, autoantigen Ge-1
, autoantigen RCD-8
, enhancer of mRNA-decapping protein 4
, human enhancer of decapping large subunit
, autoantigen RCD8