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EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009].. Additionally we are shipping EZH1 Kits (6) and EZH1 Proteins (3) and many more products for this protein.
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Human Polyclonal EZH1 Primary Antibody for EIA, IHC (p) - ABIN357745
Ogawa, Hiraoka, Taniguchi, Aiso: Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2. in Biochimica et biophysica acta 1998
Show all 5 references for ABIN357745
Human Polyclonal EZH1 Primary Antibody for IHC (p), WB - ABIN389082
Osborne-Lawrence, Welcsh, Spillman, Chandrasekharappa, Gallardo, Lovett, Bowcock: Direct selection of expressed sequences within a 1-Mb region flanking BRCA1 on human chromosome 17q21. in Genomics 1995
Show all 3 references for ABIN389082
Human Polyclonal EZH1 Primary Antibody for ELISA, WB - ABIN184879
Abel, Brody, Valdes, Erdos, McKinley, Castilla, Merajver, Couch, Friedman, Ostermeyer, Lynch, King, Welcsh, Osborne-Lawrence, Spillman, Bowcock, Collins, Weber: Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. in Genomics 1997
Chicken Polyclonal EZH1 Primary Antibody for IHC, WB - ABIN2780390
van Lohuizen, Tijms, Voncken, Schumacher, Magnuson, Wientjens: Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes. in Molecular and cellular biology 1998
The related enzymatic subunits EZH1 and EZH2 (show EZH2 Antibodies) undergo an expression switch during blood cell development.
EZH1 maintains repressive chromatin through different mechanisms.
These results clearly demonstrated an essential role of Ezh1 in the pathogenesis of hematopoietic malignancies induced by Ezh2 (show EZH2 Antibodies) insufficiency, and highlighted the differential functions of Ezh1 and Ezh2 (show EZH2 Antibodies) in hematopoiesis.
Loss of EZH1 is associated with increased liver injury and a blunted regenerative response.
Data show that histone lysine methyltransferase Ezh1 promotes toll (show TLR4 Antibodies)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip (show TOLLIP Antibodies)), contributing to full activation of the innate immunity.
presence of Ezh1 helps to maintain PRC2 occupancy on its target genes in myoblasts where Jarid2 (show JARID2 Antibodies) is not expressed.
Deletion of Ezh1 and Ezh2 (show EZH2 Antibodies) from skin results in a marked change in fate determination in epidermal progenitor cells, leading to an increase in the number of lineage-committed Merkel cells, specialized subtype of skin cells involved in mechanotransduction.
Ezh1 is an important histone methyltransferase for hematopietic stem cell maintenance.
Ezh1 has a role in promoting mRNA transcription.
while Ezh1/2-null hair follicles (HFs) arrest morphogenesis and degenerate due to defective proliferation and increased apoptosis, epidermis hyperproliferates and survives engraftment
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 (show EZH2 Antibodies) leads to reduced retinal progenitor proliferation.
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008
enhancer of zeste homolog 1 (Drosophila)
, enhancer of zeste homolog 1-like
, histone-lysine N-methyltransferase EZH1-like
, histone-lysine N-methyltransferase EZH1
, enhancer of zeste 1
, enhancer of zeste homolog 1
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, histone-lysine N-methyltransferase EZH2