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EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009].. Additionally we are shipping EZH1 Kits (8) and EZH1 Proteins (4) and many more products for this protein.
Showing 10 out of 104 products:
Human Polyclonal EZH1 Primary Antibody for ELISA, WB - ABIN249717
Abel, Brody, Valdes, Erdos, McKinley, Castilla, Merajver, Couch, Friedman, Ostermeyer, Lynch, King, Welcsh, Osborne-Lawrence, Spillman, Bowcock, Collins, Weber: Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1. in Genomics 1997
Human Polyclonal EZH1 Primary Antibody for WB - ABIN4309822
Grimaldi, Christian, Steel, Henriet, Poutanen, Brosens: Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells. in Molecular endocrinology (Baltimore, Md.) 2011
Expression of the EZH2 (show EZH2 Antibodies) homolog EZH1 is reduced in EZH2 (show EZH2 Antibodies)-deficient CML (show BCR Antibodies) LICs, creating a scenario resembling complete loss of PRC2. EZH2 (show EZH2 Antibodies) dependence of CML (show BCR Antibodies) LICs raises prospects for improved therapy of TKI-resistant CML (show BCR Antibodies) and/or eradication of disease by addition of EZH2 (show EZH2 Antibodies) inhibitors
a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR (show TSHR Antibodies) mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells
EZH1, SUZ12 (show SUZ12 Antibodies) and UXT (show UXT Antibodies) work synergistically to regulate pathway activation in the nucleus.
The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes.
These evidences suggest that EZH2 (show EZH2 Antibodies) and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 (show EZH2 Antibodies) ratio may play important roles in the pathogenesis of lymphomas
The related enzymatic subunits EZH1 and EZH2 (show EZH2 Antibodies) undergo an expression switch during blood cell development.
EZH1 maintains repressive chromatin through different mechanisms.
Ezh1 is required for neonatal heart regeneration and development.
in the skin epithelium, EED (show EED Antibodies), Suz12 (show SUZ12 Antibodies), and Ezh1/2 function largely as subunits of the PRC2 complex and have roles in skin development
the expression level of Ezh1 determines the restoration of H3K27 methylation in the absence of the canonical EZH2 (show EZH2 Antibodies)-PRC2.
These results clearly demonstrated an essential role of Ezh1 in the pathogenesis of hematopoietic malignancies induced by Ezh2 (show EZH2 Antibodies) insufficiency, and highlighted the differential functions of Ezh1 and Ezh2 (show EZH2 Antibodies) in hematopoiesis.
Loss of EZH1 is associated with increased liver injury and a blunted regenerative response.
Data show that histone lysine methyltransferase Ezh1 promotes toll (show TLR4 Antibodies)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip (show TOLLIP Antibodies)), contributing to full activation of the innate immunity.
presence of Ezh1 helps to maintain PRC2 occupancy on its target genes in myoblasts where Jarid2 (show JARID2 Antibodies) is not expressed.
Deletion of Ezh1 and Ezh2 (show EZH2 Antibodies) from skin results in a marked change in fate determination in epidermal progenitor cells, leading to an increase in the number of lineage-committed Merkel cells, specialized subtype of skin cells involved in mechanotransduction.
Ezh1 is an important histone methyltransferase for hematopietic stem cell maintenance.
Ezh1 has a role in promoting mRNA transcription.
Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 (show EZH2 Antibodies) leads to reduced retinal progenitor proliferation.
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008
enhancer of zeste homolog 1 (Drosophila)
, enhancer of zeste homolog 1-like
, histone-lysine N-methyltransferase EZH1-like
, histone-lysine N-methyltransferase EZH1
, enhancer of zeste 1
, enhancer of zeste homolog 1
, Enhancer of zeste homolog 2-A
, Polycomb protein EZH2-A
, histone-lysine N-methyltransferase EZH2