Enhancer of Zeste Homolog 1 (Drosophila) Proteins (EZH1)

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009].. Additionally we are shipping EZH1 Antibodies (104) and EZH1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EZH1 2145 Q92800
EZH1 14055 P70351
Rat EZH1 EZH1 303547  
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Top EZH1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$608.00
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EZH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) Interaction Partners

Human Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) interaction partners

  1. Expression of the EZH2 (show EZH2 Proteins) homolog EZH1 is reduced in EZH2 (show EZH2 Proteins)-deficient CML (show BCR Proteins) LICs, creating a scenario resembling complete loss of PRC2. EZH2 (show EZH2 Proteins) dependence of CML (show BCR Proteins) LICs raises prospects for improved therapy of TKI-resistant CML (show BCR Proteins) and/or eradication of disease by addition of EZH2 (show EZH2 Proteins) inhibitors

  2. a hot-spot mutation in EZH1 is the second most frequent genetic alteration in autonomous thyroid adenomas; the association between EZH1 and TSHR (show TSHR Proteins) mutations suggests a 2-hit model for the pathogenesis of these tumors, whereby constitutive activation of the cAMP pathway and EZH1 mutations cooperate to induce the hyperproliferation of thyroid cells

  3. EZH1, SUZ12 (show SUZ12 Proteins) and UXT (show UXT Proteins) work synergistically to regulate pathway activation in the nucleus.

  4. The authors report a novel PRC2-Ezh1 function that utilizes Ezh1beta as an adaptive stress sensor in the cytoplasm, thus allowing postmitotic cells to maintain tissue integrity in response to environmental changes.

  5. These evidences suggest that EZH2 (show EZH2 Proteins) and EZH1 are important in the counter-balancing mechanisms controlling proliferation/resting of lymphoid cells. The disruption of the balanced EZH2/EZH1 (show EZH2 Proteins) ratio may play important roles in the pathogenesis of lymphomas

  6. The related enzymatic subunits EZH1 and EZH2 (show EZH2 Proteins) undergo an expression switch during blood cell development.

  7. EZH1 maintains repressive chromatin through different mechanisms.

Mouse (Murine) Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) interaction partners

  1. Ezh1 is required for neonatal heart regeneration and development.

  2. in the skin epithelium, EED (show EED Proteins), Suz12 (show SUZ12 Proteins), and Ezh1/2 function largely as subunits of the PRC2 complex and have roles in skin development

  3. the expression level of Ezh1 determines the restoration of H3K27 methylation in the absence of the canonical EZH2 (show EZH2 Proteins)-PRC2.

  4. These results clearly demonstrated an essential role of Ezh1 in the pathogenesis of hematopoietic malignancies induced by Ezh2 (show EZH2 Proteins) insufficiency, and highlighted the differential functions of Ezh1 and Ezh2 (show EZH2 Proteins) in hematopoiesis.

  5. Loss of EZH1 is associated with increased liver injury and a blunted regenerative response.

  6. Data show that histone lysine methyltransferase Ezh1 promotes toll (show TLR4 Proteins)-like receptor (TLR)-triggered inflammatory cytokine production by suppressing the Toll-interacting protein (Tollip (show TOLLIP Proteins)), contributing to full activation of the innate immunity.

  7. presence of Ezh1 helps to maintain PRC2 occupancy on its target genes in myoblasts where Jarid2 (show JARID2 Proteins) is not expressed.

  8. Deletion of Ezh1 and Ezh2 (show EZH2 Proteins) from skin results in a marked change in fate determination in epidermal progenitor cells, leading to an increase in the number of lineage-committed Merkel cells, specialized subtype of skin cells involved in mechanotransduction.

  9. Ezh1 is an important histone methyltransferase for hematopietic stem cell maintenance.

  10. Ezh1 has a role in promoting mRNA transcription.

Xenopus laevis Enhancer of Zeste Homolog 1 (Drosophila) (EZH1) interaction partners

  1. Study shows that the PRC2 core components are enriched in retinal progenitors and downregulated in differentiated cells. Knockdown of the PRC2 core component Ezh2 (show EZH2 Proteins) leads to reduced retinal progenitor proliferation.

EZH1 Protein Profile

Protein Summary

EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008

Gene names and symbols associated with EZH1

  • enhancer of zeste homolog 1 (Drosophila) (EZH1)
  • enhancer of zeste homolog 1 (Drosophila) (LOC100221384)
  • enhancer of zeste homolog 1 (Drosophila) (ezh1)
  • enhancer of zeste homolog 1 (Drosophila) (Ezh1)
  • enhancer of zeste homolog 2 (ezh2-a)
  • AW557915 protein
  • enx-1 protein
  • enx1 protein
  • ezh1 protein
  • ezh2 protein
  • kmt6 protein
  • KMT6B protein
  • mKIAA0388 protein
  • si:ch211-250i3.1 protein
  • xez protein
  • zgc:136829 protein

Protein level used designations for EZH1

enhancer of zeste homolog 1 (Drosophila) , enhancer of zeste homolog 1-like , histone-lysine N-methyltransferase EZH1-like , ENX-2 , histone-lysine N-methyltransferase EZH1 , enhancer of zeste 1 , enhancer of zeste homolog 1 , Enhancer of zeste homolog 2-A , Polycomb protein EZH2-A , histone-lysine N-methyltransferase EZH2

GENE ID SPECIES
454697 Pan troglodytes
100052411 Equus caballus
100221384 Taeniopygia guttata
100351852 Oryctolagus cuniculus
100411881 Callithrix jacchus
100547448 Meleagris gallopavo
100559669 Anolis carolinensis
100604860 Nomascus leucogenys
2145 Homo sapiens
14055 Mus musculus
533087 Bos taurus
303547 Rattus norvegicus
664754 Danio rerio
420023 Gallus gallus
480516 Canis lupus familiaris
100518394 Sus scrofa
100720693 Cavia porcellus
399174 Xenopus laevis
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