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ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009].. Additionally we are shipping ESRP1 Antibodies (43) and ESRP1 Kits (3) and many more products for this protein.
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Ptbp1 (show PTBP1 Proteins) abundance is controlled in Xenopus epidermis via alternate splicing: skipping of exon 11 is the default splicing pattern, but Esrp1 stimulates ptbp1 (show PTBP1 Proteins) expression by favoring the inclusion of exon 11 up to a level that is limited by Ptbp1 (show PTBP1 Proteins) itself.
MCL1 (show MCL1 Proteins) with the deletion of 801G and 802A sites could not be correctly spliced by ESRP1 and no significant difference was seen in the expressions of isoform 1 and 3 in mutant MCL1 (show MCL1 Proteins)
ESRP1 and ESRP2 (show ESRP2 Proteins) suppress cancer cell motility via different mechanisms.
Results show that ESRP1 regulates the expression pattern of FGFR-2 (show FGFR2 Proteins) isoforms, attenuates cell growth, migration, invasion and metastasis, and is a favorable prognostic factor in pancreatic ductal adenocarcinoma.
Data suggest that alternative splicing in ESRP1 transcripts in somatotroph adenomas is essential in epithelial-mesenchymal transition progression and in response to somatostatin (show SST Proteins) analog antineoplastic treatment.
ESRP1 and PNN (show PNN Proteins) modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics.
the transcription repressor Snail (show SNAI1 Proteins) binds to E-boxes in the ESRP1 promoter, causing repression of the ESRP1 gene.
ESRP1 could be a master regulator of the EMT (show ITK Proteins) process in pituitary adenomas causing acromegaly.
deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta (show TGFB1 Proteins)-induced EMT (show ITK Proteins) and the progression of breast cancers
functions of the ESRP1 in an epithelial posttranscriptional gene expression program.
The functional significance of EMT (show ITK Proteins)-associated alternative splicing was tested by expression of the epithelial-specific splicing factor (show SLU7 Proteins) ESRP1
Loss of both Esrp1 and its paralog Esrp2 (show ESRP2 Proteins) results in widespread developmental defects with broad implications to human disease.
The expression levels of three splicing factors, ESRP1, PTB (show PTBP1 Proteins) and SF2/ASF (show SRSF1 Proteins), are significantly altered during cardiac hypertrophy in mice.
ESRP1 thus acts as a physiological regulator of the finely-tuned balance between self-renewal and commitment to a restricted developmental fate.
Esrp1 could play an important role in the morphological changes underlying embryogenesis of the placenta and embryo.
Alternative splicing of CD44 (show CD44 Proteins) mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.
Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 (show FGFR2 Proteins) splicing.
ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009
epithelial splicing regulatory protein 1
, RNA-binding motif protein 35A
, RNA-binding protein 35A
, RNA binding motif protein 35A