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Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Additionally we are shipping Epoxide Hydrolase 1, Microsomal (Xenobiotic) Antibodies (89) and Epoxide Hydrolase 1, Microsomal (Xenobiotic) Kits (1) and many more products for this protein.
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A function of a putative EH gene in the biosynthesis of a sex attractant in the jewel wasp (show WASL Proteins) Nasonia vitripennis and use of this gene to localize the site of pheromone production, is described.
Enzymes of the fatty acid degradation pathway were upregulated in DRB1-mutated plants.
cytoplasmic partitioning of COP1 under light is essential to protect HYL1 against protease X.
Data establishes that RNA binding by HYL1 dsRBD1 is essential for its function.
Data suggest a mechanism of plant miRNA maturation which involves binding of the HEN1 (show HENMT1 Proteins) methyltransferase to the DICER-LIKE 1 ribonuclease DCL1 (show CD302 Proteins)*RNA-binding protein HYL1*miRNA complex.
MicroRNA biogenesis factor DRB1 is a phosphorylation target of mitogen activated protein kinase (show MAPK1 Proteins) MPK3 (show MAPK3 Proteins) in both rice and Arabidopsis
The results suggest that HYL1 ensures the correct selection of pri-miRNA cleavage sites through homodimerization and thus contributes to gene silencing and plant development.
The C-terminal dsRBDs of DCL1 (show CD302 Proteins) and N-terminal dsRBDs of HYL1 have parallel roles.
The role of HYL1 is in establishment of stamen architecture provides insight into the molecular mechanism of male fertility.
In the miRNA processing complex, Serrate functions as a scaffold to mediate CPL1 interaction with HYL1, which needs to be dephosphorylated for optimal activity. In
AGO1 (show EIF2C1 Proteins), HYL1, and HEN1 (show HENMT1 Proteins) function in proximal-distal and vascular patterning of leaves.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 Proteins) regulation: cytochrome CYP2A5, GSTM3 (show glutathione S-transferase mu 3 (brain) Proteins), GSTM1 (show GSTM1 Proteins), ENTPD5 (show ENTPD5 Proteins),UDPGDH (show UGDH Proteins), and EPHX1.
Expression of HBSP significantly increased the formation of BPDE-DNA adduct in benzo[alpha]pyrene-treated Huh-7 hepatoma cells, and this enhancement was blocked by knockdown of microsomal epoxide hydrolase
In livers of HRN mice Cyp1a1 (show CYP1A1 Proteins), cytochrome b5 (show CYB5A Proteins) and mEH can effectively activate BaP (show PHB2 Proteins) to DNA binding species, even in the presence of very low amounts of P450 (show POR Proteins) oxidoreductase (show HSD17B6 Proteins).
sEH gene deletion is protective against ischemic stroke by a vascular mechanism linked to reduced hydration of circulating EETs
Report effect of CYP2E1 (show CYP2E1 Proteins) gene deletion in mice on expression of microsomal epoxide hydrolase in response to 4-vinylcyclohexene diepoxide exposure. Suggest ovarian expression of CYP2E1 (show CYP2E1 Proteins)/mEH may be linked.
EPHX1 in oviductal cells may enhance the development of cocultured embryos by protecting them from oxidative stress.
The results suggest that epoxide intermediates mediate methamphetamine drug dependence and that astrocytic reactions of microsomal epoxide hydrolase protein are important in the endogenous modulation in response to methamphetamine drug dependence.
Null-GSTT1 (show GSTT1 Proteins) and null-GSTM1 (show GSTM1 Proteins) genotypes and Cytochrome P4502E1 (CYP2E1 (show CYP2E1 Proteins): rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population
The SCN1A (show SCN1A Proteins) IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 gene are influencing CBZ metabolism and disposition
In conclusion, GSTs (show GSTa2 Proteins), EPHX1, and XPD (show ERCC2 Proteins) are potential genetic factors for arsenic-induced skin cancers. The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated.
the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians. However, this polymorphism was not found to be associated with breast cancer.
To be poly(ADP-ribose)polymerase-1 (PARP-1 (show PARP1 Proteins)) bound to the EPHX1 proximal promoter.
Polymorphism in the EPHX1 gene may have a significant role in differential responses to treatment with N-acetylcysteine in patients with COPD (show ARCN1 Proteins).
This review and meta-analysis suggests that EPHX1 Tyr113His polymorphism may be a risk factor for Head and Neck Cancer, while the EPHX1 His139Arg polymorphism has no association with Head and Neck Cancer risk.
Studies suggest that the presence of microsomal epoxide hydrolase 1 (EPHX1) single nucleotide polymorphisms (SNPs) may significantly affect the risk of lung, upper aerodigestive tract, breast, bladder, and ovarian carcinomas.
the genetic associations exist between mEH polymorphisms and lung cancer susceptibility in Asian populations
These results demonstrate that 2-AG is an endogenous substrate for EPHX1, a potential role of EPHX1 in the endocannabinoid signaling and a new AA biosynthetic pathway.
Studied EPHX1 SNPs to analyze effect on increased expression of EPHX1 gene in Berkshire liver by total of 192 pigs.
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
epoxide hydrolase 1, microsomal (xenobiotic)
, epoxide hydrolase 1
, Epoxide hydrolase 1
, epoxide hydratase
, microsomal epoxide hydrolase
, epoxide hydrolase 1 (microsomal xenobiotic hydrolase)
, liver microsomal xenobiotic epoxide hydrolase