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catalyzes the hydration of a wide range of xenobiotic arene oxides.
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Data, including data from mutant strain of mice, suggest critical role of Ephx1 in regulation of vasodynamics (specifically regulation of cerebral blood flow) and suggest that deregulation of endogenous signaling pathways (such as eicosanoid metabolism) is undesirable gain of function associated with E404D variant of Ephx1.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 ELISA Kits) regulation: cytochrome CYP2A5, GSTM3 (show glutathione S-transferase mu 3 (brain) ELISA Kits), GSTM1 (show GSTM1 ELISA Kits), ENTPD5 (show ENTPD5 ELISA Kits),UDPGDH (show UGDH ELISA Kits), and EPHX1.
Expression of HBSP significantly increased the formation of BPDE-DNA adduct in benzo[alpha]pyrene-treated Huh-7 hepatoma cells, and this enhancement was blocked by knockdown of microsomal epoxide hydrolase
In livers of HRN mice Cyp1a1 (show CYP1A1 ELISA Kits), cytochrome b5 (show CYB5A ELISA Kits) and mEH can effectively activate BaP (show PHB2 ELISA Kits) to DNA binding species, even in the presence of very low amounts of P450 (show POR ELISA Kits) oxidoreductase (show HSD17B6 ELISA Kits).
sEH gene deletion is protective against ischemic stroke by a vascular mechanism linked to reduced hydration of circulating EETs
Report effect of CYP2E1 (show CYP2E1 ELISA Kits) gene deletion in mice on expression of microsomal epoxide hydrolase in response to 4-vinylcyclohexene diepoxide exposure. Suggest ovarian expression of CYP2E1 (show CYP2E1 ELISA Kits)/mEH may be linked.
EPHX1 in oviductal cells may enhance the development of cocultured embryos by protecting them from oxidative stress.
The results suggest that epoxide intermediates mediate methamphetamine drug dependence and that astrocytic reactions of microsomal epoxide hydrolase protein are important in the endogenous modulation in response to methamphetamine drug dependence.
catalyzes the hydration of a wide range of xenobiotic arene oxides
, epoxide hydrolase 1
, microsomal epoxide hydrolase
, epoxide hydrolase 1 (microsomal xenobiotic hydrolase)
, liver microsomal xenobiotic epoxide hydrolase