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Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Additionally we are shipping Epoxide Hydrolase 1, Microsomal (Xenobiotic) Proteins (10) and Epoxide Hydrolase 1, Microsomal (Xenobiotic) Kits (2) and many more products for this protein.
Showing 10 out of 107 products:
Arabidopsis thaliana Polyclonal EPHX1 Primary Antibody for RIP, WB - ABIN334544
Manavella, Hagmann, Ott, Laubinger, Franz, Macek, Weigel: Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1. in Cell 2012
Show all 3 references for 334544
Human Monoclonal EPHX1 Primary Antibody for EIA, WB - ABIN371867
van Loo, Kingma, Arand, Wubbolts, Janssen: Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis. in Applied and environmental microbiology 2006
Show all 2 references for 371867
Cow (Bovine) Polyclonal EPHX1 Primary Antibody for WB - ABIN2785633
Luo, Norris, Bolstad, Knecht, Grant: Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase. in Journal of molecular biology 2008
A function of a putative EH gene in the biosynthesis of a sex attractant in the jewel wasp (show WASL Antibodies) Nasonia vitripennis and use of this gene to localize the site of pheromone production, is described.
Results show that HYL1 and SE directly interact with HIGLE to processes primary transcripts of MIRNA genes into mature miRNAs.
SMEK1 (show SMEK1 Antibodies), as a suppressor, inhibits MAPK (show MAPK1 Antibodies) activation to attenuate HYL1 phosphorylation; SMEK1 (show SMEK1 Antibodies) assembles a functional PP4 (show PPP4C Antibodies) to target HYL1 for dephosphorylation
Further analysis revealed that the steady state level of HYL1 protein in plants under osmotic stress is dependent on the SnRK2 kinases. Additionally, our results suggest that the SnRK2 kinases physically associate with the miRNA processing components SE and HYL1 and can phosphorylate these proteins in vitro.
Lariat RNAs localized in nuclear bodies, and partially co-localize with HYL1, and both DCL1 (show CD302 Antibodies) and HYL1 were mis (show AMH Antibodies)-localized in dbr1 (show DBR1 Antibodies)-2... we thus propose that lariat RNAs, as decoys, inhibit miRNA processing, suggesting a hitherto unknown layer of regulation in miRNA biogenesis.
Enzymes of the fatty acid degradation pathway were upregulated in DRB1-mutated plants.
cytoplasmic partitioning of COP1 under light is essential to protect HYL1 against protease X.
Data establishes that RNA binding by HYL1 dsRBD1 is essential for its function.
Data suggest a mechanism of plant miRNA maturation which involves binding of the HEN1 (show HENMT1 Antibodies) methyltransferase to the DICER-LIKE 1 ribonuclease DCL1 (show CD302 Antibodies)*RNA-binding protein HYL1*miRNA complex.
MicroRNA biogenesis factor DRB1 is a phosphorylation target of mitogen activated protein kinase (show MAPK1 Antibodies) MPK3 (show MAPK3 Antibodies) in both rice and Arabidopsis
The results suggest that HYL1 ensures the correct selection of pri-miRNA cleavage sites through homodimerization and thus contributes to gene silencing and plant development.
Data, including data from mutant strain of mice, suggest critical role of Ephx1 in regulation of vasodynamics (specifically regulation of cerebral blood flow) and suggest that deregulation of endogenous signaling pathways (such as eicosanoid metabolism) is undesirable gain of function associated with E404D variant of Ephx1.
Six proteins were regulated at both basal and inducible levels exhibiting the largest dynamic range of Nrf2 (show NFE2L2 Antibodies) regulation: cytochrome CYP2A5, GSTM3 (show glutathione S-transferase mu 3 (brain) Antibodies), GSTM1 (show GSTM1 Antibodies), ENTPD5 (show ENTPD5 Antibodies),UDPGDH (show UGDH Antibodies), and EPHX1.
Expression of HBSP significantly increased the formation of BPDE-DNA adduct in benzo[alpha]pyrene-treated Huh-7 hepatoma cells, and this enhancement was blocked by knockdown of microsomal epoxide hydrolase
In livers of HRN mice Cyp1a1 (show CYP1A1 Antibodies), cytochrome b5 (show CYB5A Antibodies) and mEH can effectively activate BaP (show PHB2 Antibodies) to DNA binding species, even in the presence of very low amounts of P450 (show POR Antibodies) oxidoreductase (show HSD17B6 Antibodies).
sEH gene deletion is protective against ischemic stroke by a vascular mechanism linked to reduced hydration of circulating EETs
Report effect of CYP2E1 (show CYP2E1 Antibodies) gene deletion in mice on expression of microsomal epoxide hydrolase in response to 4-vinylcyclohexene diepoxide exposure. Suggest ovarian expression of CYP2E1 (show CYP2E1 Antibodies)/mEH may be linked.
EPHX1 in oviductal cells may enhance the development of cocultured embryos by protecting them from oxidative stress.
The results suggest that epoxide intermediates mediate methamphetamine drug dependence and that astrocytic reactions of microsomal epoxide hydrolase protein are important in the endogenous modulation in response to methamphetamine drug dependence.
Structural characterization of human microsomal epoxide hydrolase by combined homology modeling, molecular dynamics simulations, and molecular docking calculations has been reported.
Y113H polymorphism in EPHX1 gene contributed to increased susceptibility to COPD (show ARCN1 Antibodies) in the Kazakhstan population.
EPHX1 polymorphisms were not associated with sporadic colorectal neoplasms.
This study demonstrated that two SNPs might play roles in the process of nicotine metabolism and abstinence, rs1051740 being more important; and EPHX SNPs (rs1051740 and rs2234922) are associated with the effectiveness of Nicotine Replacement Therapy .
No association was found between EPHX1 and COPD (show ARCN1 Antibodies); however, a minor effect of EPHX1 on COPD (show ARCN1 Antibodies) risk was not completely excluded.
CYP1B1 (show CYP1B1 Antibodies)/EPHX1 genotyping could help to predict the risk of DNA damage and to optimize doses of coal tar (show RBM8A Antibodies) and UVR exposure in psoriatic patients in whom Goeckerman therapy was applied.
Null-GSTT1 (show GSTT1 Antibodies) and null-GSTM1 (show GSTM1 Antibodies) genotypes and Cytochrome P4502E1 (CYP2E1 (show CYP2E1 Antibodies): rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population
The SCN1A (show SCN1A Antibodies) IVS5-91G>A SNP is associated with susceptibility to epilepsy. SNPs in EPHX1 gene are influencing CBZ metabolism and disposition
In conclusion, GSTs (show GSTa2 Antibodies), EPHX1, and XPD (show ERCC2 Antibodies) are potential genetic factors for arsenic-induced skin cancers. The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated.
the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians. However, this polymorphism was not found to be associated with breast cancer.
Studied EPHX1 SNPs to analyze effect on increased expression of EPHX1 gene in Berkshire liver by total of 192 pigs.
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
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