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ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008].. Additionally we are shipping ESCO1 Antibodies (12) and many more products for this protein.
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By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion.
Data show that acetyltransferase Esco1 colocalizes with cohesin throughout the cell cycle and down-regulates expression of neighboring genes.
This is the first report of somatic mutations within ESCO1 and CHTF18 (show CHTF18 Proteins) in endometrial tumors and of MRE11A (show MRE11A Proteins) mutations in microsatellite-stable endometrial tumors.
this is the first evidence that Eco1 represses transcription by interacting with histone demethylase, LSD1 (show KDM1A Proteins) to convert chromatin to inactive state.
Variants in ESCO1 is associated with predisposition for TMPRSS2-ERG fusion in prostate cancer.
EFO1 and EFO2 (show ESCO2 Proteins) are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion
This study identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 (show SMC3 Proteins) acetylation is a conserved mechanism in regulating sister chromatid cohesion.
ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005
ECO1 homolog 1
, N-acetyltransferase ESCO1
, establisment of cohesion 1 homolog 1
, CTF7 homolog 1
, ESO1 homolog 1
, establishment factor-like protein 1
, establishment of cohesion 1 homolog 1