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Establishment of Cohesion 1 Homolog 2 (ESCO2) ELISA Kits

ESCO2 encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Additionally we are shipping ESCO2 Antibodies (22) and ESCO2 Proteins (3) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat ESCO2 ESCO2 691979  
Anti-Mouse ESCO2 ESCO2 71988 Q8CIB9
Anti-Human ESCO2 ESCO2 157570 Q56NI9
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More ELISA Kits for ESCO2 Interaction Partners

Xenopus laevis Establishment of Cohesion 1 Homolog 2 (ESCO2) interaction partners

  1. XEco2 is responsible for Smc3 (show SMC3 ELISA Kits) acetylation and sister chromatid cohesion.

Zebrafish Establishment of Cohesion 1 Homolog 2 (ESCO2) interaction partners

  1. esco2 is upregulated during fin regeneration. esco2 knockdown adversely affects tissue and bone growth in regenerating fins-consistent with role in skeletal morphogenesis. knockdown diminishes cx43 (show GJA1 ELISA Kits) expression which is required for cell-cell communication

  2. This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS cells and supports that normal gene expression and translation requires ESCO2 function.

  3. although many cells required Esco2 to establish cohesion, 10-20% of cells had only weakened cohesion in the absence of Esco2, suggesting that compensatory cohesion mechanisms exist in these cells that undergo a normal mitotic division.

  4. Esco2 depleted zebrafish embryos exhibit features that resemble Roberts Syndrome, including mitotic defects, craniofacial abnormalities and limb truncations.

Mouse (Murine) Establishment of Cohesion 1 Homolog 2 (ESCO2) interaction partners

  1. To Roberts syndrome(RBS), mouse Esco2 turns out to be a cell viability factor, the absence of which results in severe chromosome segregation defects and apoptosis.

  2. ESCO2 may play a vital role in meiosis in both males and females.

  3. Esco2 is needed for cohesin acetylation in PCH and that this modification is required for the proper distribution of cohesin on mitotic chromosomes and for centromeric cohesion

  4. Esco2 promotes neuronal differentiation by repressing Notch (show NOTCH1 ELISA Kits) signaling.

Human Establishment of Cohesion 1 Homolog 2 (ESCO2) interaction partners

  1. The Esco2 is required for double-strand break (DSB) repair, which is consistent with previous studies in Roberts syndrome(RBS) cells.

  2. the ESCO2 gene mutation responsible for developmental abnormalities maps to chromosome 8p21.

  3. These results demonstrated that the Staf (show ZNF143 ELISA Kits) binding site functioned as the basal transcriptional activator (show Abt1 ELISA Kits) of the S phase-specific gene ESCO2, but other mechanisms are required for cell cycle-dependent expression.

  4. In situ hybridisation on human embryos showed ESCO2 expression in the brain, face, limb, kidney and gonads, which corresponds to the structures affected in Roberts syndrome.

  5. ESCO2 has an S-phase specific role in the maintenance of genome stability

  6. EFO1 (show ESCO1 ELISA Kits) and EFO2 are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion

  7. Inactivating mutations in ESCO2 cause SC phocomelia and Roberts syndrome: there is no phenotype-genotype correlation.

  8. We used Western blot analysis to demonstrate the absence of the ESCO2-truncated protein in cells derived from both fetuses and in a lymphoblastoid cell line derived from the parents.

  9. detection of an ESCO2 frameshift mutation in Roberts syndrome in a Pakistani family

  10. Loss of ESCO2 acetyltransferase activity contributes to the pathogenesis of Roberts syndrome/SC phocomelia.

ESCO2 Antigen Profile

Antigen Summary

This gene encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome.

Gene names and symbols associated with ESCO2

  • establishment of cohesion 1 homolog 2 (S. cerevisiae) (ESCO2) antibody
  • establishment of sister chromatid cohesion N-acetyltransferase 2 (Esco2) antibody
  • establishment of cohesion 1 homolog 2 (S. cerevisiae) (esco2) antibody
  • establishment of cohesion 1 homolog 2 (LOC100341332) antibody
  • establishment of cohesion 1 homolog 2 (esco2) antibody
  • establishment of cohesion 1 homolog 2 (S. cerevisiae) (Esco2) antibody
  • establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) antibody
  • 2410004I17Rik antibody
  • D030072L07Rik antibody
  • EFO2 antibody
  • MGC115718 antibody
  • RBS antibody
  • si:dkey-217m5.6 antibody
  • zgc:111795 antibody

Protein level used designations for ESCO2

establishment of cohesion 1 homolog 2 (S. cerevisiae) , N-acetyltransferase ESCO2 , establishment of cohesion 1 homolog 2 , XEco2 , ECO1 homolog 2 , un-named hi2865 , unm hi2865

GENE ID SPECIES
422004 Gallus gallus
472926 Pan troglodytes
486098 Canis lupus familiaris
538949 Bos taurus
691979 Rattus norvegicus
734660 Xenopus laevis
100158558 Xenopus (Silurana) tropicalis
100341332 Oryctolagus cuniculus
445395 Danio rerio
71988 Mus musculus
157570 Homo sapiens
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