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EHF encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). Additionally we are shipping EHF Antibodies (25) and EHF Kits (4) and many more products for this protein.
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This study suggests that ESE3 plays an important role in the carcinogenesis of Esophageal Squamous Cell Carcinoma through changes in subcellular localization and may act as a tumor suppressor gene in Esophageal Squamous Cell Carcinoma.
EHF modifies the CF phenotype by altering capabilities of the epithelial cell to correctly process the folding and trafficking of mutant p.Phe508del-CFTR (show CFTR Proteins).
Results suggest PPAR-gamma (show PPARG Proteins) to be involved in the regulation of ESE-3b expression during monocyte-derived dendritic cells (moDCs) development and that ESE-3 expression is not correlated with the immunogenicity of dendritic cells (DCs).
The SRC (show SRC Proteins) family tyrosine kinase (show TXK Proteins) HCK (show HCK Proteins) and the ETS (show ETS1 Proteins) family transcription factors SPIB (show SPIB Proteins) and EHF regulate transcytosis across a human follicle-associated epithelium model.
ESE-3b is the functionally most important ESE-3 isoform in dendritic cells
Low ESE3/EHF expression was also associated with increased biochemical recurrence of prostate cancer and reduced overall survival after prostatectomy
EHF mRNA levels differentiate ovarian carcinoma from malignant mesothelioma. EHF may be a novel prognostic marker in ovarian carcinoma.
These results indicate that EHF-mediated RUVBL1 expression allows colon tumour cells to avoid p53 (show TP53 Proteins)-mediated apoptosis.
Overexpression of ESE-3 protein in human bronchial smooth muscle cells inhibits MMP-1 (show MMP1 Proteins) promoter activity, suggesting that ESE-3 may function as a transcriptional repressor.
In addition, we show the possible involvement of co-factors CBP (show CREBBP Proteins) and p300 (show EP300 Proteins) in ESE-3-mediated DR-5 (show TNFRSF10B Proteins) up-regulation.
These data provide insights into the mechanisms underlying epithelial development and aging, identifying EHF as a regulator of cornea epithelial identity
This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene.
ETS homologous factor
, ESE3 transcription factor
, ETS domain-containing transcription factor
, epithelium-specific Ets transcription factor 3
, ets homologous factor