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Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.. Additionally we are shipping ETV4 Proteins (5) and ETV4 Kits (1) and many more products for this protein.
Showing 10 out of 70 products:
Cow (Bovine) Polyclonal ETV4 Primary Antibody for WB - ABIN2779533
Span, Manders, Heuvel, Beex, Sweep: E1AF expression levels are not associated with prognosis in human breast cancer. in Breast cancer research and treatment 2003
Show all 4 references for ABIN2779533
Human Monoclonal ETV4 Primary Antibody for WB - ABIN1107153
Yu, Xia, Wang, Wang, Pan, Kwong, Hortobagyi, Hung: Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. in Molecular carcinogenesis 2006
Show all 3 references for ABIN1107153
Human Monoclonal ETV4 Primary Antibody for ELISA, WB - ABIN969121
Zhu, Jiang, Shen, Wang, Zong, Li, Yang, Niu, Liu, Chen, Hu, Gu: Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. in The Journal of biological chemistry 2005
Show all 3 references for ABIN969121
Human Monoclonal ETV4 Primary Antibody for ELISA, WB - ABIN560805
Han, Mehra, Dhanasekaran, Yu, Menon, Lonigro, Wang, Gong, Wang, Shankar, Laxman, Shah, Varambally, Palanisamy, Tomlins, Kumar-Sinha, Chinnaiyan: A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5-ETV4 fusion protein in prostate cancer. in Cancer research 2008
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Human Polyclonal ETV4 Primary Antibody for IHC, ELISA - ABIN1533733
Friedman, Ostermeyer, Lynch, Welcsh, Szabo, Meza, Anderson, Dowd, Lee, Rowell: 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors. in Genomics 1995
Show all 2 references for ABIN1533733
Human Polyclonal ETV4 Primary Antibody for EIA, FACS - ABIN452983
Wei, Liu, Ge, Zhou, Xu, Chen, Gu, Jiang: Identification of E1AF as a target gene of E2F1-induced apoptosis in response to DNA damage. in Journal of biochemistry 2008
PEA3-subgroup transcription factors are key players of the Met signaling integration involved in regulation of migration and invasiveness of tumor cells.
ACC1 (show ACACA Antibodies) and ACLY (show ACLY Antibodies) regulate the levels of ETV4 under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (show ACACA Antibodies)/ACLY (show ACLY Antibodies)-alpha-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output
ETV4 overexpression is associated with prostate cancer aggressiveness.
molecular mechanism underlying DBC1 (show DBC1 Antibodies) function in PEA3-mediated transcription involves inhibition of SIRT1 (show SIRT1 Antibodies) interaction with PEA3 and of SIRT1 (show SIRT1 Antibodies)-mediated deacetylation of PEA3
Implicate Pea3 as a mediator of liver metastases in colorectal cancer.
Silencing of ETV4 suppresses invasion of prostate cancer cells by inhibiting the expression of uPA (show PRAP1 Antibodies)/uPAR (show PLAUR Antibodies) as well as (MMP)-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies)
data suggest that polyomavirus enhancer activator 3 and epithelium-specific transcription factor-1 (show HNF1A Antibodies) may play important roles in pluri potent and tumorigenic embryonic carcinoma cells.
developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1 (show ETV1 Antibodies), ETV4, and ETV5 (show ETV5 Antibodies) in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa (show FLVCR1 Antibodies) specimens using RNA probes
PEA3 regulates OCT4 (show POU5F1 Antibodies) gene expression as a transcriptional activator
Study reveals molecular insight into how the Ets (show ETS1 Antibodies) family transcription factor Pea3 favors EMT (show ITK Antibodies) and contributes to tumorigenesis via a negative regulatory loop with Cyclin D2 (show CCND2 Antibodies), a new Pea3 target gene.
etv5a (show ETV5 Antibodies) and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development
Pea3 and erm (show ETV5 Antibodies) are required for zebrafish pronephrogenesis and can functionally complement each other, and the wt1a gene may be one of their downstream targets.
Overlapping functions of pea3 ETS (show ETS1 Antibodies) transcription factors in FGF signaling during zebrafish development are reported.
ETS-related transcription factors ETV4 and ETV5 (show ETV5 Antibodies) are involved in proliferation and induction of differentiation-associated genes in embryonic stem (ES) cells.
paracrine signaling via fibroblast growth factor 2 (Fgf2 (show FGF2 Antibodies)) and Mapk (show MAPK1 Antibodies) between these diverged tumor subclones causes enhanced expression of the Pea3 transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones.
Study hypothesized that PEA3 might play an essential role in the activation of the FAK (show PTK2 Antibodies) gene during tumor metastasis.
oncogenic Etv4 promotes prostate cancer metastasis in response to coactivation of PI3-kinase and Ras signaling pathways in a genetically engineered model of highly penetrant, metastatic prostate cancer
PEA3-null fibroblasts exhibit impaired c-src activation and motility defects.
Smad2 (show SMAD2 Antibodies) and PEA3 regulate RGC-32 (show C13orf15 Antibodies) transcription which is essential for smooth muscle cell differentiation from neural crest cells.
study provides evidence for a protumorigenic role of PEA3 factors in breast neoplasia, and supports targeting the PEA3 transcription factor family in breast cancer
Induction of Pea3 gene expression by peripheral signals is required to coordinate the central position and terminal arborization of specific sets of spinal motor neurons.
PEA3 expression in developing motor neurons is regulated by GDNF (show GDNF Antibodies) signals from the limb bud.
Transcriptional activator that binds to the enhancer of the adenovirus E1A gene\; the core-binding sequence is 5'GT-3'.
ets variant 4
, ETS translocation variant gene 4
, ets variant gene 4 (E1A enhancer binding protein, E1AF)
, ets domain protein
, ETS translocation variant 4
, EWS protein/E1A enhancer binding protein chimera
, adenovirus E1A enhancer-binding protein
, ets variant gene 4 (E1A enhancer-binding protein, E1AF)
, polyomavirus enhancer activator 3 homolog
, ETS translocation variant 4-like
, polyomavirus enhancer activator-3
, ETS domain-containing transcription factor PEA3
, ETS-domain transcription factor pea3
, ETS variant protein 4
, POLYOMAVIRUS ENHANCER ACTIVATOR 3 (PEA3 PROTEIN) (ETS TRANSLOCATION VARIANT 4)