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ETV6 encodes an ETS family transcription factor. Additionally we are shipping ETV6 Antibodies (107) and ETV6 Kits (2) and many more products for this protein.
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Dominant-negative truncated ETV6 with deletions of the ETS (show ETS1 Proteins) domain or the PNT (show ETS2 Proteins) domain interfered with repression by full-length ETV6 and affected expression of early hematopoietic and erythroid markers in embryos.
the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood circulatory system
ETV6/RUNX1 (show RUNX1 Proteins) transcript is a target of RNA-binding protein (show PTBP1 Proteins) IGF2BP1 (show IGF2BP1 Proteins) in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.
The study shows a low representation of ETV6-RUNX1 (show RUNX1 Proteins) fusion oncogenes among pediatric acute lymphoblastic leukemia patients from King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.
the ETV6-NTRK3 fusion (show NTRK3 Proteins) might identify a subset of gastrointestinal stromal tumours with peculiar clinicopathological characteristics
our results demonstrate that MIR181A1 and ETV6/RUNX1 (show RUNX1 Proteins) regulate each other, and we propose that a double negative loop involving MIR181A1 and ETV6/RUNX1 (show RUNX1 Proteins) may contribute to ETV6/RUNX1 (show RUNX1 Proteins)-driven arrest of differentiation in pre-B ALL.
germline ETV6 mutations associated with leukemia and thrombocytopenia were identifies in multiple individuals. Mutant ETV6 showed decreased ability to regulate expression of other genes.
We observed significant enrichment of the neuroactive ligand-receptor interaction pathway in TCF3 (show TCF3 Proteins)-PBX1 (show PBX1 Proteins) as well as an enrichment of genes involved in immunity and infection pathways in ETV6-RUNX1 (show RUNX1 Proteins) subtype
Our study demonstrated that ETV6 was markedly involved in the development of non-small cell lung cancer and could serve as a potential prognostic marker for this deadly disease
Suggest germline ETV6 variations as the basis of a novel genetic syndrome associated with predisposition to childhood acute lymphoblastic leukemia.
Molecular analysis of ETV6 gene rearranged mammary analogue secretory carcinoma of salivary glands tumors with lack of classical ETV6-NTRK3 fusion (show NTRK3 Proteins).
the ETV6/ARG oncoprotein contributes to autonomous cell growth by compensating for the requirement of growth factor through activating STAT5 (show STAT5A Proteins) signaling, which leads to the up-regulation of c-Myc (show MYC Proteins).
ETV6 DNA binding inhibition is established by the stability of its inhibitory helix
Studied the combination of Etv6-RUNX1 (show RUNX1 Proteins) and Pax5 (show PAX5 Proteins)(+/-) alleles, they generated a transplantable B220 (show PTPRC Proteins) + CD19 (show CD19 Proteins)+ B-ALL with a significant disease incidence; RNA-seq analysis showed a gene expression pattern consistent with arrest at the pre-B stage.
In murine models of B-cell progenitors, evidence found that ETV6- RUNX1 (show RUNX1 Proteins) alters the expression of cytoskeletal regulatory genes, resulting in a block of the CDC42 (show CDC42 Proteins) signaling pathway, and compromises the chemotactic response to CXCL12 (show CXCL12 Proteins).
ETV6-SAM (show TTN Proteins) domain interface mutations block ETV6-NTRK3 (show NTRK3 Proteins)-induced cellular transformation
the autoinhibition of ETV6 DNA binding by sequences C-terminal to its ETS (show ETS1 Proteins) domain
find that both IRS1 (show IRS1 Proteins) and kinase active IGF1R (show IGF1R Proteins) are required for ETV6-NTRK3 (show NTRK3 Proteins) transformation, that tyrosine phosphorylated IRS1 (show IRS1 Proteins) is present in high molecular weight complexes with EN and IGF1R (show IGF1R Proteins), and that EN colocalizes with IGF1R (show IGF1R Proteins) at the plasma membrane
Cytogenetic study of 33 children with ETV6-RUNX1 (show RUNX1 Proteins) positive acute lymphoblastic leukemia predict long term survival.
TEL binding to IRF-8 (show IRF8 Proteins) for recruitment of HDAC3 (show HDAC3 Proteins) is regulated by gamma-interferon (show IFNG Proteins)
the ability of TEL to repress transcription and suppress growth is regulated by sumoylation and nuclear export
nucleo-cytoplasmic delocalization of the major isoform of TEL-ETV6 is regulated by V-src (show SRC Proteins)
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
transcription factor ETV6
, ets variant gene 6 (TEL oncogene)
, TEL oncogene
, ets variant 6
, ETS translocation variant 6
, ETS-related protein Tel1
, TEL1 oncogene
, ets domain protein