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EIF1AX encodes an essential eukaryotic translation initiation factor. Additionally we are shipping EIF1AX Antibodies (22) and many more products for this protein.
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Coexpression of mutant NRAS (show NRAS Proteins) and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer.
Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor (show EIF4G1 Proteins) 1A (eIF1A) which interacts with both RPS3 (show RPS3 Proteins) and RPS10e.
Mutation in EIF1AX gene is associated with Uveal Melanoma.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (show GNAQ Proteins), GNA11 (show GNA11 Proteins), and EIF1AX mutations.
results indicate that the interactions between eIF1A and eIF5B (show EIF5B Proteins) are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B (show EIF5B Proteins) interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments
Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1 (show RNF2 Proteins), SF3B1 (show SF3B2 Proteins), or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1 (show SF3B2 Proteins)-mutated tumors are associated with late metastasis
BAP1 (show RNF2 Proteins), SF3B1 (show SF3B2 Proteins), and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk.
We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules.
The finding of this study suggested that an SF3B1 (show SF3B2 Proteins) or EIF1AX mutation is present in a substantial subset of primary LMNs underscores that these tumors genetically resemble uveal melanoma and are different from cutaneous melanoma at the genetic level.
Then, activated p38 (show CRK Proteins) further enhanced the docking of activating transcription factor 4 (ATF4 (show ATF4 Proteins)) onto the CHOP (CCAAT/enhancer-binding protein homologous protein (show DDIT3 Proteins)) promoter via eIF2alpha (show EIF2A Proteins) to enhance apoptosis
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.
Putative eukaryotic translation initiation factor 1A
, eIF-1A X isoform
, eukaryotic translation initiation factor 1A, X chromosome
, eukaryotic translation initiation factor 1A, X-chromosomal
, eukaryotic translation initiation factor 4C
, eukaryotic translation initiation factor 1A, Y-linked