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Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. Additionally we are shipping EIF2S2 Proteins (9) and many more products for this protein.
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Human Polyclonal EIF2S2 Primary Antibody for WB - ABIN1881289
Rajesh, Iyer, Suragani, Ramaiah: Intersubunit and interprotein interactions of alpha- and beta-subunits of human eIF2: Effect of phosphorylation. in Biochemical and biophysical research communications 2008
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This study provides evidence that even a mild mutation in eIF2B (show EIF2B4 Antibodies), leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs.
GCN2 (show EIF2AK4 Antibodies) activation increased phosphorylation of its substrate eIF2alpha (show EIF2A Antibodies) and the induction of the integrated stress response master regulator, ATF4 (show ATF4 Antibodies).
BMP-2 (show BMP2 Antibodies) stimulates differentiation of myoblasts into osteoblasts via the PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies)-ATF4 (show ATF4 Antibodies) pathway but in addition stimulates Tmem119, which itself increases ATF4 (show ATF4 Antibodies)
This study extends our understanding of the roles played by GCN1 in GCN2 (show EIF2AK4 Antibodies) activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha (show EIF2A Antibodies) kinase.
Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2.
Mass spectrometry of CXCR4 (show CXCR4 Antibodies) immunoprecipitates revealed a specific interaction with the pentameric eukaryotic translation initiation factor (show EIF2A Antibodies) 2B.
This study provides mechanistic insight into the role of eIF5-carboxyl terminal domain's dynamic interplay with eIF1 and eIF2beta
These findings suggest that alpha and beta subunits of eIF2 (show EIF2S1 Antibodies) interact with each other and the beta-subunit (show POLG Antibodies) plays a critical role both in the regulation and function of eIF2 (show EIF2S1 Antibodies).
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.
eukaryotic translation initiation factor 2 subunit 2
, eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
, eukaryotic translation initiation factor 2 beta
, eukaryotic translation initiation factor 2 subunit beta
, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)
, eukaryote initiation factor 2 beta
, protein phosphatase 1, regulatory subunit 67
, eukaryotic initiation factor 2 beta (eIF-2 beta)