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anti-Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Antibodies

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Additionally we are shipping EIF2S1 Proteins (19) and EIF2S1 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF2S1 13665 Q6ZWX6
EIF2S1 54318 P68101
EIF2S1 1965 P05198
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Top anti-EIF2S1 Antibodies at antibodies-online.com

Showing 10 out of 125 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rabbit Un-conjugated IF, IHC (p), WB EIF2S1 Antibody (N-term)  western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the EIF2S1 antibody detected the EIF2S1 protein (arrow). Confocal immunofluorescent analysis of EIF2S1 Antibody (N-term)  with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-EIF2S1 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to EIF2S1 on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of EIF2S1 expression in transfected 293T cell line by EIF2S1 monoclonal antibody (M01), clone 3H12-C11. Lane 1: EIF2S1 transfected lysate(36.1 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$357.50
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Human Placenta (formalin-fixed, paraffin-embedded) stained with EIF2S1 antibody ABIN214045 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Adrenal (formalin-fixed, paraffin-embedded) stained with EIF2S1 antibody ABIN214045 at 10 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Anti-EIF2S1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN959311 concentration 5 ug/ml. 50 μL Log in to see 8 to 10 Days
$451.00
Details

EIF2S1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) ,
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Top referenced anti-EIF2S1 Antibodies

  1. Human Monoclonal EIF2S1 Primary Antibody for IF, WB - ABIN393738 : Kulkarni, Mittal, Devasagayam, Pal: Hsp90 mediates activation of the heme regulated eIF-2 alpha kinase during oxidative stress. in Indian journal of biochemistry & biophysics 2010 (PubMed)
    Show all 5 references for ABIN393738

  2. Mouse (Murine) Polyclonal EIF2S1 Primary Antibody for IF, IHC (p) - ABIN657392 : Shiota, Eto, Yokomizo, Tada, Takeuchi, Masubuchi, Inokuchi, Tatsugami, Kuroiwa, Uchiumi, Seki, Naito: Sorafenib with doxorubicin augments cytotoxicity to renal cell cancer through PERK inhibition. in International journal of oncology 2010 (PubMed)
    Show all 4 references for ABIN657392

  3. Human Monoclonal EIF2S1 Primary Antibody for EIA, IHC (p) - ABIN781543 : Peña, Harris: Dengue virus modulates the unfolded protein response in a time-dependent manner. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 references for ABIN781543

  4. Human Polyclonal EIF2S1 Primary Antibody for IF, IHC (p) - ABIN319275 : de Haro, Méndez, Santoyo: The eIF-2alpha kinases and the control of protein synthesis. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996 (PubMed)
    Show all 2 references for ABIN319275

  5. Human Polyclonal EIF2S1 Primary Antibody for IF, IHC (p) - ABIN197046 : Saelens, Kalai, Vandenabeele: Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 2 references for ABIN197046

  6. Human Polyclonal EIF2S1 Primary Antibody for IF, IHC (p) - ABIN197542 : Kubota, Obata, Ota, Sasaki, Ito: Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN197542

  7. Cow (Bovine) Polyclonal EIF2S1 Primary Antibody for WB - ABIN2778882 : Puri, Mirshahi, Cheung, Natarajan, Maher, Kellum, Sanyal: Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease. in Gastroenterology 2008 (PubMed)

  8. Chicken Polyclonal EIF2S1 Primary Antibody for IHC, WB - ABIN2778883 : Marciniak, Garcia-Bonilla, Hu, Harding, Ron: Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK. in The Journal of cell biology 2006 (PubMed)

More Antibodies against EIF2S1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 (show TARDBP Antibodies) toxicity in amyotrophic lateral sclerosis disease models.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Data indicate that 5xFAD-related pathologies do not necessarily require hyperphosphorylation of eIF2alpha (show EIF2A Antibodies) to emerge.

  2. Endoplasmic reticulum stress suppressed CReP (show PPP1R15B Antibodies) expression in an IRE1 alpha (show ERN1 Antibodies)-dependent manner, which increased eIF2alpha (show EIF2A Antibodies) phosphorylation and consequently attenuated protein synthesis.

  3. eIF2alphaP acts as a molecular switch that dictates either cell survival or death by activated Akt (show AKT1 Antibodies) in response to oxidative stress.

  4. aberrant phosphorylation of eukaryotic initiation factor (show EIF4G1 Antibodies)-2a (eIF2a (show EIF2A Antibodies)) may induce synaptic failure and neurodegeneration through persistent translational inhibition of global protein synthesis.

  5. Alteration of protein homeostasis and eIF2alpha (show EIF2A Antibodies) phosphorylation status by pathogenic huntingtin (show HTT Antibodies) appears to be an important cause of striatal cell death.

  6. Data indicate that prolonged endoplasmic reticulum stress inhibits protein synthesis independently of translation initiation factor eIF2alpha (show EIF2A Antibodies)-P.

  7. This study demonistrated that Genetic deletion of eIF2alpha (show EIF2A Antibodies) kinase PERK (show EIF2AK3 Antibodies) prevented enhanced phosphorylation of eIF2alpha (show EIF2A Antibodies) and deficits in protein synthesis, synaptic plasticity and spatial memory in animal disease model of Alzheimer's disease.

  8. eIF2alpha (show EIF2A Antibodies) phosphorylation in the context of the ER stress response plays a role in cell survival by counteracting the p53 (show TP53 Antibodies)-mediated mitochondrial apoptosis in response to statins.

  9. eIF2a (show EIF2A Antibodies) is hyperphosphorylated in the cortex of aged mice. Young human-ApoE4 targeted-replacement mice show increased p-eIF2a/eIF2a (show EIF2A Antibodies) levels in both cortex and hippocampus.

  10. the induction of REDD1 (show DDIT4 Antibodies) gene expression was shown to require the protein kinase (show CDK7 Antibodies) PERK (show EIF2AK3 Antibodies) and enhanced phosphorylation of its substrate, the alpha-subunit (show POLG Antibodies) of eukaryotic initiation factor (show EIF4G1 Antibodies) 2.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. In conclusion, the immediate-early (show JUN Antibodies) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor (show EIF2A Antibodies) eIF2alpha (show EIF2A Antibodies).

Human Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Our work suggests that OLA1 (show OLA1 Antibodies) is a novel translational GTPase (show RACGAP1 Antibodies) and plays a suppressive role in translation and cell survival, as well as cancer growth and progression.

  2. a delay in eIF2-bound GTP (show AK3 Antibodies) hydrolysis should occur. In this work, we reconstructed this situation and found that such a delay leads to the redistribution of initiation complexes in favor to downstream AUG codons.

  3. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (show NOX4 Antibodies)) is induced downstream of ATF4 (show ATF4 Antibodies), binds to a PP1 (show PPA1 Antibodies)-targeting subunit GADD34 (show PPP1R15A Antibodies) at the endoplasmic reticulum, and inhibits PP1 (show PPA1 Antibodies) activity to increase eIF2alpha (show EIF2A Antibodies) phosphorylation and ATF4 (show ATF4 Antibodies) levels.

  4. Classical swine fever virus (CSFV) infection increased the phosphorylation of eukaryotic translation initiation factor (show EIF2A Antibodies) (eIF)2alpha and its kinase PKR (show PKLR Antibodies). The activation of PKR (show PKLR Antibodies) during CSFV infection is beneficial to the virus.

  5. eIF2alpha (show EIF2A Antibodies) phosphorylation plays a role in hypoxia-induced translational attenuation

  6. phosphorylation of eIF2alpha during early brain reperfusion is carried out by PERK, these findings suggest that there is prolonged activation of the unfolded protein response in the reperfused brain.

  7. Results indicate an evolutionary lineage of translation initiation factor eIF2alpha (show EIF2A Antibodies)/gamma from the functionally related elongation factor (show TSFM Antibodies) eEF1Balpha/eEF1A (show EEF1A1 Antibodies) complex.

  8. multiple domains in I-1 target cellular PP1 (show PPA1 Antibodies) complexes, and I-1 has a role as a cellular regulator of eIF2alpha (show EIF2A Antibodies) phosphorylation

  9. Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.

  10. Our results demonstrate that Ebp1 (show NFKB1 Antibodies) is a new dsRNA-binding protein that acts as a cellular inhibitor of eIF2alpha (show EIF2A Antibodies) phosphorylation suggesting that it could be involved in protein translation control

Cow (Bovine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Caspase (show CASP3 Antibodies)(s)-dependent proteolysis of molecular chaperones and eIF2alpha (show EIF2A Antibodies) may be novel signaling pathways of apoptosis.

EIF2S1 Antigen Profile

Protein Summary

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2\; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3\; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987

Gene names and symbols associated with EIF2S1

  • eukaryotic translation Initiation Factor 2alpha (eIF-2alpha) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (eif2s1) antibody
  • eukaryotic translation initiation factor 2 alpha subunit (LOC693063) antibody
  • eukaryotic translation initiation factor 2 alpha subunit (CNI00230) antibody
  • eukaryotic translation initiation factor 2 alpha subunit (THAPSDRAFT_105) antibody
  • Eukaryotic translation initiation factor 2 subunit 1 (if2a) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (LOC100339093) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (LOC100350462) antibody
  • eukaryotic translation initiation factor 2 subunit 1 (if2a) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha (LOC100155472) antibody
  • eukaryotic translation initiation factor 2, subunit 1 alpha b (eif2s1b) antibody
  • 35kDa antibody
  • 0910001O23Rik antibody
  • 2410026C18Rik antibody
  • CG9946 antibody
  • deIF2alpha antibody
  • Dmel\\CG9946 antibody
  • EIF-2 antibody
  • eIF-2 a antibody
  • eIF-2 alpha antibody
  • EIF-2A antibody
  • EIF-2alpha antibody
  • EIF2 antibody
  • eIF2 alpha antibody
  • eIF2-alpha antibody
  • EIF2A antibody
  • eIF2alpha antibody
  • eif2s1 antibody
  • elF2alpha antibody
  • fb19d01 antibody
  • IF2A_DROME antibody
  • l(1)14Cf antibody
  • l(1)19-153 antibody
  • M(1)8e3-10 antibody
  • M(1)14C antibody
  • M(1)19-153 antibody
  • wu:fb19d01 antibody

Protein level used designations for EIF2S1

CG9946-PA , eIF-2alpha-PA , eukaryotic initiation factor 2alpha , eukaryotic translation initiation factor 2 , eukaryotic translation initiation factor 2alpha , minute (1) 14C , EIF-2A , EIF-2alpha , eIF-2-alpha , eukaryotic translation initiation factor 2 subunit 1 , eukaryotic translation initiation factor 2 subunit alpha , eukaryotic translation initiation factor 2 alpha subunit , Eukaryotic translation initiation factor 2 subunit 1 , eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa , eIF-2A , eIF-2alpha , eukaryotic translation initiation factor 2A , eIF2 alpha subunit , eukaryotic translation initiation factor 2, subunit 1 (alpha )

GENE ID SPECIES
32617 Drosophila melanogaster
448087 Xenopus (Silurana) tropicalis
693063 Bombyx mori
3259501 Cryptococcus neoformans var. neoformans JEC21
7449310 Thalassiosira pseudonana CCMP1335
100195154 Salmo salar
100339093 Oryctolagus cuniculus
100350462 Oryctolagus cuniculus
100528138 Ictalurus punctatus
100587728 Nomascus leucogenys
13665 Mus musculus
54318 Rattus norvegicus
100155472 Sus scrofa
321564 Danio rerio
1965 Homo sapiens
380444 Xenopus laevis
423279 Gallus gallus
480361 Canis lupus familiaris
327694 Bos taurus
100174029 Pongo abelii
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