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Eukaryotic Translation Initiation Factor 2 Subunit 1 Proteins (EIF2S1)

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Additionally we are shipping EIF2S1 Antibodies (125) and EIF2S1 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF2S1 13665 Q6ZWX6
EIF2S1 54318 P68101
EIF2S1 1965 P05198
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Top EIF2S1 Proteins at antibodies-online.com

Showing 10 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,025.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,082.67
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,839.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details

EIF2S1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human , ,
,

Top referenced EIF2S1 Proteins

  1. Human EIF2S1 Protein expressed in Escherichia coli (E. coli) - ABIN667786 : Boyce, Bryant, Jousse, Long, Harding, Scheuner, Kaufman, Ma, Coen, Ron, Yuan: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. in Science (New York, N.Y.) 2005 (PubMed)
    Show all 2 references for ABIN667786

More Proteins for Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Therapeutic modulation of eIF2alpha phosphorylation rescues TDP-43 (show TARDBP Proteins) toxicity in amyotrophic lateral sclerosis disease models.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Data indicate that 5xFAD-related pathologies do not necessarily require hyperphosphorylation of eIF2alpha (show EIF2A Proteins) to emerge.

  2. Endoplasmic reticulum stress suppressed CReP (show PPP1R15B Proteins) expression in an IRE1 alpha (show ERN1 Proteins)-dependent manner, which increased eIF2alpha (show EIF2A Proteins) phosphorylation and consequently attenuated protein synthesis.

  3. eIF2alphaP acts as a molecular switch that dictates either cell survival or death by activated Akt (show AKT1 Proteins) in response to oxidative stress.

  4. aberrant phosphorylation of eukaryotic initiation factor (show EIF4G1 Proteins)-2a (eIF2a (show EIF2A Proteins)) may induce synaptic failure and neurodegeneration through persistent translational inhibition of global protein synthesis.

  5. Alteration of protein homeostasis and eIF2alpha (show EIF2A Proteins) phosphorylation status by pathogenic huntingtin (show HTT Proteins) appears to be an important cause of striatal cell death.

  6. Data indicate that prolonged endoplasmic reticulum stress inhibits protein synthesis independently of translation initiation factor (show TIF1 Proteins) eIF2alpha (show EIF2A Proteins)-P.

  7. This study demonistrated that Genetic deletion of eIF2alpha (show EIF2A Proteins) kinase PERK (show EIF2AK3 Proteins) prevented enhanced phosphorylation of eIF2alpha (show EIF2A Proteins) and deficits in protein synthesis, synaptic plasticity and spatial memory in animal disease model of Alzheimer's disease.

  8. eIF2alpha (show EIF2A Proteins) phosphorylation in the context of the ER stress response plays a role in cell survival by counteracting the p53 (show TP53 Proteins)-mediated mitochondrial apoptosis in response to statins.

  9. eIF2a (show EIF2A Proteins) is hyperphosphorylated in the cortex of aged mice. Young human-ApoE4 targeted-replacement mice show increased p-eIF2a/eIF2a (show EIF2A Proteins) levels in both cortex and hippocampus.

  10. the induction of REDD1 (show DDIT4 Proteins) gene expression was shown to require the protein kinase (show CDK7 Proteins) PERK (show EIF2AK3 Proteins) and enhanced phosphorylation of its substrate, the alpha-subunit (show POLG Proteins) of eukaryotic initiation factor (show EIF4G1 Proteins) 2.

Pig (Porcine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. In conclusion, the immediate-early (show JUN Proteins) IE180 protein of pseudorabies virus has the previously uncharacterized ability to suppress phosphorylation levels of the eukaryotic translation initiation factor (show EIF2A Proteins) eIF2alpha (show EIF2A Proteins).

Human Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Our work suggests that OLA1 (show OLA1 Proteins) is a novel translational GTPase (show RACGAP1 Proteins) and plays a suppressive role in translation and cell survival, as well as cancer growth and progression.

  2. a delay in eIF2-bound GTP (show AK3 Proteins) hydrolysis should occur. In this work, we reconstructed this situation and found that such a delay leads to the redistribution of initiation complexes in favor to downstream AUG codons.

  3. The reactive oxygen species-generating NADPH oxidase-4 (Nox4 (show NOX4 Proteins)) is induced downstream of ATF4 (show ATF4 Proteins), binds to a PP1 (show PPA1 Proteins)-targeting subunit GADD34 (show PPP1R15A Proteins) at the endoplasmic reticulum, and inhibits PP1 (show PPA1 Proteins) activity to increase eIF2alpha (show EIF2A Proteins) phosphorylation and ATF4 (show ATF4 Proteins) levels.

  4. Classical swine fever virus (CSFV) infection increased the phosphorylation of eukaryotic translation initiation factor (show EIF2A Proteins) (eIF)2alpha and its kinase PKR (show PKLR Proteins). The activation of PKR (show PKLR Proteins) during CSFV infection is beneficial to the virus.

  5. eIF2alpha (show EIF2A Proteins) phosphorylation plays a role in hypoxia-induced translational attenuation

  6. phosphorylation of eIF2alpha during early brain reperfusion is carried out by PERK, these findings suggest that there is prolonged activation of the unfolded protein response in the reperfused brain.

  7. Results indicate an evolutionary lineage of translation initiation factor (show TIF1 Proteins) eIF2alpha (show EIF2A Proteins)/gamma from the functionally related elongation factor (show TSFM Proteins) eEF1Balpha/eEF1A (show EEF1A1 Proteins) complex.

  8. multiple domains in I-1 target cellular PP1 (show PPA1 Proteins) complexes, and I-1 has a role as a cellular regulator of eIF2alpha (show EIF2A Proteins) phosphorylation

  9. Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.

  10. Our results demonstrate that Ebp1 (show NFKB1 Proteins) is a new dsRNA-binding protein that acts as a cellular inhibitor of eIF2alpha (show EIF2A Proteins) phosphorylation suggesting that it could be involved in protein translation control

Cow (Bovine) Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) interaction partners

  1. Caspase (show CASP3 Proteins)(s)-dependent proteolysis of molecular chaperones and eIF2alpha (show EIF2A Proteins) may be novel signaling pathways of apoptosis.

EIF2S1 Protein Profile

Protein Summary

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2\; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3\; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987

Gene names and symbols associated with EIF2S1

  • eukaryotic translation Initiation Factor 2alpha (eIF-2alpha)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (eif2s1)
  • eukaryotic translation initiation factor 2 alpha subunit (LOC693063)
  • eukaryotic translation initiation factor 2 alpha subunit (CNI00230)
  • eukaryotic translation initiation factor 2 alpha subunit (THAPSDRAFT_105)
  • Eukaryotic translation initiation factor 2 subunit 1 (if2a)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (LOC100339093)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (LOC100350462)
  • eukaryotic translation initiation factor 2 subunit 1 (if2a)
  • eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1)
  • eukaryotic translation initiation factor 2, subunit 1 alpha (Eif2s1)
  • eukaryotic translation initiation factor 2, subunit 1 alpha (LOC100155472)
  • eukaryotic translation initiation factor 2, subunit 1 alpha b (eif2s1b)
  • 35kDa protein
  • 0910001O23Rik protein
  • 2410026C18Rik protein
  • CG9946 protein
  • deIF2alpha protein
  • Dmel\\CG9946 protein
  • EIF-2 protein
  • eIF-2 a protein
  • eIF-2 alpha protein
  • EIF-2A protein
  • EIF-2alpha protein
  • EIF2 protein
  • eIF2 alpha protein
  • eIF2-alpha protein
  • EIF2A protein
  • eIF2alpha protein
  • eif2s1 protein
  • elF2alpha protein
  • fb19d01 protein
  • IF2A_DROME protein
  • l(1)14Cf protein
  • l(1)19-153 protein
  • M(1)8e3-10 protein
  • M(1)14C protein
  • M(1)19-153 protein
  • wu:fb19d01 protein

Protein level used designations for EIF2S1

CG9946-PA , eIF-2alpha-PA , eukaryotic initiation factor 2alpha , eukaryotic translation initiation factor 2 , eukaryotic translation initiation factor 2alpha , minute (1) 14C , EIF-2A , EIF-2alpha , eIF-2-alpha , eukaryotic translation initiation factor 2 subunit 1 , eukaryotic translation initiation factor 2 subunit alpha , eukaryotic translation initiation factor 2 alpha subunit , Eukaryotic translation initiation factor 2 subunit 1 , eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa , eIF-2A , eIF-2alpha , eukaryotic translation initiation factor 2A , eIF2 alpha subunit , eukaryotic translation initiation factor 2, subunit 1 (alpha )

GENE ID SPECIES
32617 Drosophila melanogaster
448087 Xenopus (Silurana) tropicalis
693063 Bombyx mori
3259501 Cryptococcus neoformans var. neoformans JEC21
7449310 Thalassiosira pseudonana CCMP1335
100195154 Salmo salar
100339093 Oryctolagus cuniculus
100350462 Oryctolagus cuniculus
100528138 Ictalurus punctatus
100587728 Nomascus leucogenys
13665 Mus musculus
54318 Rattus norvegicus
100155472 Sus scrofa
321564 Danio rerio
1965 Homo sapiens
380444 Xenopus laevis
423279 Gallus gallus
480361 Canis lupus familiaris
327694 Bos taurus
100174029 Pongo abelii
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