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Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) ELISA Kits

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\\\\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 105. Additionally we are shipping Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies (107) and Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human EIF2AK4 EIF2AK4 440275 Q9P2K8
Anti-Mouse EIF2AK4 EIF2AK4 27103 Q9QZ05
Anti-Rat EIF2AK4 EIF2AK4 114859  
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More ELISA Kits for Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Interaction Partners

Human Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. IDO (show IDO1 ELISA Kits), through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC ELISA Kits), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA ELISA Kits) and GLS2 (show GLS2 ELISA Kits)

  2. EIF2AK4 mutation was associated with pulmonary veno-occlusive disease. PVOD patients who were not significantly exposed to trichloroethylene were more likely to harbour EIF2AK4 mutations.

  3. Data show that sequenced eukaryotic translation initiation factor 2 alpha kinase 4 protein (EIF2AK4) with a homozygous mutation in all five families: c.3344C>T(p.P1115L).

  4. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  5. Upon deprivation of various amino acids, activated GCN2 up-regulates ATF4 (show ATF4 ELISA Kits) to induce expression of the stress response protein Sestrin2, which is required to sustain repression of mTORC1 by blocking its lysosomal localization

  6. IDO (show IDO1 ELISA Kits) through GCN2 kinase activation inhibits CD4 (show CD4 ELISA Kits)(+) T-cell proliferation and down-regulates key enzymes that directly or indirectly promote FA synthesis, a prerequisite for CD4 (show CD4 ELISA Kits)(+) T-cell proliferation and differentiation into effector cell lineages.

  7. GCN2 can exert its proapoptotic function in cancer cell death by posttranslational mechanisms.

  8. GCN2 activation and phosphorylation of eIF2alpha (show EIF2A ELISA Kits) in response to mTORC1 inhibition are necessary for autophagy.

  9. This study is the first to examine the perceptual response to CPET in patients with PVOD who were carriers of EIF2AK4 mutations compared with PAH patients matched for resting haemodynamics and pulmonary function

  10. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. Dietary EAA sensing depends on physiologic need, but not GCN2.

  2. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  3. acute amino acid starvation suppressed intestinal inflammation via a mechanism dependent on GCN2; hence, results reveal a mechanism that couples amino acid sensing with control of intestinal inflammation via GCN2

  4. Gcn2 & Atf4 (show ATF4 ELISA Kits) are involved in L-proline metabolism regulation in embryonic stem cells.

  5. Metabolic stress signals delivered by GCN2 inhibit innate inflammatory responses to apoptotic cells, restricting adaptive immunity and preventing autoimmunity. GCN2 activation by halofunginone halobromide potently reduced autoimmune reactivity.

  6. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  7. Data indicate that the crystal structures of murine and yeast GCN2 protein kinase C-terminal domain (CTD) showed dimers.

  8. The results suggest that the GCN2 kinase-dependent sensing of indoleamine 2,3-dioxygenase activity represents an important trigger to the experimental autoimmune encephalomyelitis remission phase.

  9. Deletion of the eIF2alpha Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.

  10. The present study provides the first direct evidence that inhibition of GCN2 activity by GCN2 gene deletion attenuates the development of heart failure.

Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antigen Profile

Antigen Summary

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999

Gene names and symbols associated with EIF2AK4

  • eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 4 (eif2ak4) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4) antibody
  • 2610011M03 antibody
  • EIF2AK4 antibody
  • GCN2 antibody
  • Gcn2-like antibody
  • MGCN2 antibody

Protein level used designations for EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4 , eukaryotic translation initiation factor 2-alpha kinase 4-like , GCN2 protein , GCN2 eIF2alpha kinase , GCN2-like protein , eukaryotic translation initiation factor 2-alpha kinase 4

GENE ID SPECIES
423285 Gallus gallus
453321 Pan troglodytes
478257 Canis lupus familiaris
513829 Bos taurus
100392095 Callithrix jacchus
579979 Strongylocentrotus purpuratus
100031798 Monodelphis domestica
100088614 Ornithorhynchus anatinus
100187226 Ciona intestinalis
100232582 Taeniopygia guttata
100358284 Oryctolagus cuniculus
100428309 Macaca mulatta
100552145 Anolis carolinensis
100606228 Nomascus leucogenys
100216307 Xenopus (Silurana) tropicalis
440275 Homo sapiens
27103 Mus musculus
114859 Rattus norvegicus
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