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anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antibodies

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999. Additionally we are shipping Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF2AK4 440275 Q9P2K8
EIF2AK4 27103 Q9QZ05
EIF2AK4 114859  
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Top anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies at antibodies-online.com

Showing 10 out of 114 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of GCN2 (arrow) using GCN2 Antibody (N-term G11) (ABIN391197). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the GCN2 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Western blot analysis of GCN2 (arrow) using GCN2 Antibody 0.1 mg Log in to see 10 to 12 Days
$375.38
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse liver tissue labeled with Anti-Phospho-GCN2 (Thr898) Polyclonal Antibody, Unconjugated (ABIN684943) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse small intestine tissue labeled with Anti-Phospho-GCN2 (Thr898) Polyclonal Antibody, Unconjugated (ABIN684943) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated IP, WB Detection of Human GCN2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg), 293T (T, 50 mcg) and NIH3T3 (50 mcg) cells. Antibodies: Affinity purified rabbit anti-GCN2 antibody ABIN151140 used at 0.1 mcg/ml for WB (A and B) and at 3 mcg/mg lysate for IP (B). GCN2 was also immunoprecipitated using another GCN2 Ab, which is an affinity purified antibody to a downstream epitope from GCN2. Detection: Chemiluminescence with an exposure time of 10 seconds (A and B). 100 μL Log in to see 5 to 7 Days
$486.94
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB Lane 3: Recombinant Human EIF2AK4 Protein 2.5ng 100 μg Log in to see 4 to 6 Days
$200.00
Details
Mouse Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti phospho-GCN2 (Thr667) Polyclonal Antibody, Unconjugated (ABIN684958) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse liver labeled with Rabbit Anti phospho-GCN2 (Thr667) Polyclonal Antibody, Unconjugated (ABIN684958) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunocytochemistry/Immunofluorescence: GCN2 Antibody [NBP1-31679] - Sample: HeLa cells were fixed in iced-cold MeOH for 5 min. Green: EIF2AK4 protein stained by GCN2 antibody, C-term diluted at 1:500. Blue: Hoechst 33343 staining. Western Blot: GCN2 Antibody [NBP1-31679] - Sample (30 ug of whole cell lysate) A: H1299 B: Molt-4 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with EIF2AK4 antibody ABIN396905 at 1:50 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 7 to 9 Days
$451.00
Details

EIF2AK4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Antibodies

  1. Human Polyclonal EIF2AK4 Primary Antibody for IHC (p), WB - ABIN391197 : Lu, László, Miao, Chen, Wu: The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2. in The Journal of biological chemistry 2009 (PubMed)
    Show all 2 references for ABIN391197

  2. Human Polyclonal EIF2AK4 Primary Antibody for IF (p), IHC (p) - ABIN684943 : Lehman, Ryeom, Koumenis: Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma. in Scientific reports 2015 (PubMed)

  3. Human Polyclonal EIF2AK4 Primary Antibody for IP, WB - ABIN151140 : Rahmani, Davis, Crabtree, Habibi, Nguyen, Dent, Grant: The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. in Molecular and cellular biology 2007 (PubMed)

More Antibodies against Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 Interaction Partners

Cow (Bovine) Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.

Human Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. This is the first reported case of EIF2AK4 mutation in PVOD in a Chinese patient population. We found the frameshift EIF2AK4 mutation c.1392delT (p.Arg465fs) in this case.

  2. IDO (show IDO1 Antibodies), through GCN2 kinase activation, downregulates the levels of TCRcomplex tchain and cMyc (show MYC Antibodies), resulting in the suppression of Tcell proliferation and a reduction in the levels of LDHA (show LDHA Antibodies) and GLS2 (show GLS2 Antibodies)

  3. EIF2AK4 mutation was associated with pulmonary veno-occlusive disease. PVOD patients who were not significantly exposed to trichloroethylene were more likely to harbour EIF2AK4 mutations.

  4. Data show that sequenced eukaryotic translation initiation factor 2 alpha kinase 4 protein (EIF2AK4) with a homozygous mutation in all five families: c.3344C>T(p.P1115L).

  5. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  6. Upon deprivation of various amino acids, activated GCN2 up-regulates ATF4 (show ATF4 Antibodies) to induce expression of the stress response protein Sestrin2, which is required to sustain repression of mTORC1 by blocking its lysosomal localization

  7. IDO (show IDO1 Antibodies) through GCN2 kinase activation inhibits CD4 (show CD4 Antibodies)(+) T-cell proliferation and down-regulates key enzymes that directly or indirectly promote FA synthesis, a prerequisite for CD4 (show CD4 Antibodies)(+) T-cell proliferation and differentiation into effector cell lineages.

  8. GCN2 can exert its proapoptotic function in cancer cell death by posttranslational mechanisms.

  9. GCN2 activation and phosphorylation of eIF2alpha (show EIF2A Antibodies) in response to mTORC1 inhibition are necessary for autophagy.

  10. This study is the first to examine the perceptual response to CPET in patients with PVOD who were carriers of EIF2AK4 mutations compared with PAH patients matched for resting haemodynamics and pulmonary function

Mouse (Murine) Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) interaction partners

  1. Inhibition of eIF2alpha phosphorylation via PERK suppression and reversal of de novo protein synthesis deficits can mitigate cognitive deficits in neurodegenerative diseases.

  2. Dietary EAA sensing depends on physiologic need, but not GCN2.

  3. Targeting ALDH18A1 activated the serine/threonine protein kinase GCN2 (general control nonderepressible 2) to inhibit protein synthesis in melanoma.

  4. acute amino acid starvation suppressed intestinal inflammation via a mechanism dependent on GCN2; hence, results reveal a mechanism that couples amino acid sensing with control of intestinal inflammation via GCN2

  5. Gcn2 & Atf4 (show ATF4 Antibodies) are involved in L-proline metabolism regulation in embryonic stem cells.

  6. Metabolic stress signals delivered by GCN2 inhibit innate inflammatory responses to apoptotic cells, restricting adaptive immunity and preventing autoimmunity. GCN2 activation by halofunginone halobromide potently reduced autoimmune reactivity.

  7. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis

  8. Data indicate that the crystal structures of murine and yeast GCN2 protein kinase C-terminal domain (CTD) showed dimers.

  9. The results suggest that the GCN2 kinase-dependent sensing of indoleamine 2,3-dioxygenase activity represents an important trigger to the experimental autoimmune encephalomyelitis remission phase.

  10. Deletion of the eIF2alpha Kinase GCN2 fails to rescue the memory decline associated with Alzheimer's disease.

Eukaryotic Translation Initiation Factor 2 alpha Kinase 4 (EIF2AK4) Antigen Profile

Protein Summary

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1\; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999

Gene names and symbols associated with EIF2AK4

  • eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 4 (eif2ak4) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 4 (Eif2ak4) antibody
  • 2610011M03 antibody
  • EIF2AK4 antibody
  • GCN2 antibody
  • Gcn2-like antibody
  • MGCN2 antibody

Protein level used designations for EIF2AK4

eukaryotic translation initiation factor 2 alpha kinase 4 , eukaryotic translation initiation factor 2-alpha kinase 4-like , GCN2 protein , GCN2 eIF2alpha kinase , GCN2-like protein , eukaryotic translation initiation factor 2-alpha kinase 4

GENE ID SPECIES
423285 Gallus gallus
453321 Pan troglodytes
478257 Canis lupus familiaris
513829 Bos taurus
100392095 Callithrix jacchus
579979 Strongylocentrotus purpuratus
100031798 Monodelphis domestica
100088614 Ornithorhynchus anatinus
100187226 Ciona intestinalis
100232582 Taeniopygia guttata
100358284 Oryctolagus cuniculus
100428309 Macaca mulatta
100552145 Anolis carolinensis
100606228 Nomascus leucogenys
100216307 Xenopus (Silurana) tropicalis
440275 Homo sapiens
27103 Mus musculus
114859 Rattus norvegicus
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