You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) Antibodies

The protein encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. Additionally we are shipping EIF2AK2 Kits (14) and EIF2AK2 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF2AK2 5610 P19525
EIF2AK2 19106 Q03963
EIF2AK2 54287 Q63184
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-EIF2AK2 Antibodies at antibodies-online.com

Showing 10 out of 259 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells treated with starved 24h, using PKR (Phospho-Thr258) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using PKR (Phospho-Thr258) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-EIF2AK2  Antibody Titration: 0.125 µg/mL  Positive Control: Human Stomach 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from 293 cells, using PKR (Ab-258) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of PKR in rat lung tissue with this product at 2.5 μg/ml. Western blot analysis of PKR in A431 whole cell lysate with this product at (A) 0.5, (B) 1 and (C) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of PKR in rat lung tissue with this product at 5 μg/ml. Western blot analysis of PKR in Caco-2 whole cell lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of PKR on a A431 cell lysate (Human epithelial carcinoma, ATCC CRL-1555). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- human PKR antibody. Immunofluorescence staining of human endothelial cells. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated IF, IHC (p) 0.1 mL Log in to see 6 to 8 Days
$308.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mL Log in to see 6 to 8 Days
$308.00
Details

EIF2AK2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
,
,
, , , , , , , , , , , , , ,
Mouse (Murine) , ,

,
Rat (Rattus) ,


,

Top referenced anti-EIF2AK2 Antibodies

  1. Human Polyclonal EIF2AK2 Primary Antibody for EIA, IHC (p) - ABIN360663 : Peel, Bredesen: Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. in Neurobiology of disease 2003 (PubMed)
    Show all 5 references for ABIN360663

  2. Human Polyclonal EIF2AK2 Primary Antibody for EIA, IHC (p) - ABIN360664 : Pang, Christianson, Keeble, Koretsky, Bagby: The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC. in The Journal of biological chemistry 2002 (PubMed)
    Show all 5 references for ABIN360664

  3. Human Monoclonal EIF2AK2 Primary Antibody for IF, IP - ABIN968165 : Barber, Tomita, Hovanessian, Meurs, Katze: Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli. in Biochemistry 1991 (PubMed)
    Show all 4 references for ABIN968165

  4. Human Polyclonal EIF2AK2 Primary Antibody for EIA, IHC (p) - ABIN500507 : Meurs, Chong, Galabru, Thomas, Kerr, Williams, Hovanessian: Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. in Cell 1990 (PubMed)
    Show all 4 references for ABIN500507

  5. Human Polyclonal EIF2AK2 Primary Antibody for EIA, IHC (p) - ABIN500505 : Saelens, Kalai, Vandenabeele: Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 references for ABIN500505

  6. Human Polyclonal EIF2AK2 Primary Antibody for IF, IHC (p) - ABIN197544 : Pataer, Vorburger, Barber, Chada, Mhashilkar, Zou-Yang, Stewart, Balachandran, Roth, Hunt, Swisher: Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). in Cancer research 2002 (PubMed)
    Show all 3 references for ABIN197544

  7. Human Polyclonal EIF2AK2 Primary Antibody for IF, IHC (p) - ABIN197554 : Ruf, Lackey, Warudkar, Sample: Protection from interferon-induced apoptosis by Epstein-Barr virus small RNAs is not mediated by inhibition of PKR. in Journal of virology 2005 (PubMed)
    Show all 3 references for ABIN197554

  8. Human Polyclonal EIF2AK2 Primary Antibody for ELISA, WB - ABIN1533108 : Thomis, Doohan, Samuel: Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2 alpha protein kinase from human cells. in Virology 1992 (PubMed)
    Show all 3 references for ABIN1533108

  9. Human Polyclonal EIF2AK2 Primary Antibody for IHC, ELISA - ABIN1532075 : Kuhen, Shen, Samuel: Mechanism of interferon action sequence of the human interferon-inducible RNA-dependent protein kinase (PKR) deduced from genomic clones. in Gene 1996 (PubMed)
    Show all 3 references for ABIN1532075

  10. Human Polyclonal EIF2AK2 Primary Antibody for IHC, WB - ABIN2792224 : Alisi, Mele, Spaziani, Tavolaro, Palescandolo, Balsano: Thr 446 phosphorylation of PKR by HCV core protein deregulates G2/M phase in HCC cells. in Journal of cellular physiology 2005 (PubMed)

More Antibodies against EIF2AK2 Interaction Partners

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. the expression of a Tat (show TAT Antibodies) construct containing mutations in the basic region (49-57aa), which is responsible for the interaction with PKR (show PKLR Antibodies), favored neither parasite growth nor IL-10 (show IL10 Antibodies) expression in infected macrophages.

  2. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL Antibodies) and HDAC8 (show HDAC8 Antibodies) mutations and PKR (show PKLR Antibodies) activation.

  3. The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 Antibodies), which is mediated by continual activation of PKR (show PKLR Antibodies) and degradation of PP1 (show PPA1 Antibodies).

  4. The sole essential function of cytomegalovirus TRS1 (show PLEKHA5 Antibodies) is to antagonize host PKR (show PKLR Antibodies).

  5. results show that ceramide acts at two distinct levels of the insulin (show INS Antibodies) signaling pathway (IRS1 (show IRS1 Antibodies) and Akt (show AKT1 Antibodies)). PKR (show PKLR Antibodies), which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS Antibodies) resistance in muscle cells.

  6. Classical swine fever virus (CSFV) infection increased the phosphorylation of eukaryotic translation initiation factor (show EIF2A Antibodies) (eIF)2alpha (show EIF2S1 Antibodies) and its kinase PKR (show PKLR Antibodies). The activation of PKR (show PKLR Antibodies) during CSFV infection is beneficial to the virus.

  7. these data indicate a pivotal role for PKR's protein-binding function on the proliferation of pancreatic beta cells through TRAF2 (show TRAF2 Antibodies)/RIP1 (show UQCRFS1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/c-Myc (show MYC Antibodies) pathways.

  8. The results from this study indicate an important role of RAX (show RAX Antibodies)/PKR (show PKLR Antibodies) association in regulating PKR (show PKLR Antibodies) activity as well as ethanol neurotoxicity

  9. The G3BP1 (show G3BP1 Antibodies)-Caprin1-PKR (show PKLR Antibodies) complex represents a new mode of PKR (show PKLR Antibodies) activation and is important for antiviral activity of G3BP1 (show G3BP1 Antibodies) and PKR (show PKLR Antibodies) during infection with mengovirus.

  10. The data support a model in which activating RNAs induce formation of a back-to-back parallel PKR (show PKLR Antibodies) kinase dimer whereas nonactivating RNAs either fail to induce dimerization or produce an alternative, inactive dimer configuration.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL Antibodies) and HDAC8 (show HDAC8 Antibodies) mutations and PKR activation.

  2. Deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation.

  3. results show that ceramide acts at two distinct levels of the insulin (show INS Antibodies) signaling pathway (IRS1 (show IRS1 Antibodies) and Akt (show AKT1 Antibodies)). PKR, which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS Antibodies) resistance in muscle cells.

  4. Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 Antibodies) R) functions as negative regulator of PKR/Eif2ak2 (protein kinase (show CDK7 Antibodies) R) in development of postnatal anterior pituitary tissue.

  5. Data indicate increasing expression of PKR during TNF-a (show TNF Antibodies)-induced osteoclast formation. Its inhibition prevents TNF-a (show TNF Antibodies)-induced bone destruction in vivo and can be then considered as new therapeutic target for bone disease.

  6. The authors show that Murine cytomegalovirus m142 and m143 knockout mutants attain organ titers equivalent to those attained by wild-type virus in Pkr knockout mice.

  7. these data indicate a pivotal role for PKR's protein-binding function on the proliferation of pancreatic beta cells through TRAF2 (show TRAF2 Antibodies)/RIP1 (show RALBP1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/c-Myc (show MYC Antibodies) pathways.

  8. Activated PKR inhibits pancreatic beta-cell proliferation through sumoylation-dependent stabilization of P53 (show TP53 Antibodies).

  9. These data indicate that the association between PKR and TRBP (show TARBP2 Antibodies) integrates metabolism with translational control and inflammatory signaling and plays important roles in metabolic homeostasis and disease.

  10. The age-associated accumulation of somatic mutations that occurs in the Nup98 (show NUP98 Antibodies)-HOXD13 (show HOXD13 Antibodies) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene.

EIF2AK2 Antigen Profile

Protein Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with EIF2AK2

  • eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) antibody
  • eukaryotic translation initiation factor 2-alpha kinase 2 (eif2ak2) antibody
  • eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2) antibody
  • 2310047A08Rik antibody
  • 4732414G15Rik antibody
  • AI467567 antibody
  • AI747578 antibody
  • DKFZp469K1934 antibody
  • EIF2AK1 antibody
  • EIF2AK2 antibody
  • Pkr antibody
  • Prkr antibody
  • Tik antibody

Protein level used designations for EIF2AK2

double-stranded RNA-activated protein kinase , interferon-induced, double-stranded RNA-activated protein kinase , p68 kinase , P1/eIF-2A protein kinase , interferon-inducible RNA-dependent protein kinase , IFN-stimulated dsRNA-activated eIF2-alpha kinase 2 , double-stranded RNA activated protein kinase , eukaryotic translation initiation factor 2-alpha kinase 2 , double stranded RNA activated protein kinase , eIF-2A protein kinase 2 , interferon-inducible elF2alpha kinase , protein kinase, interferon-inducible double stranded RNA dependent , tyrosine-protein kinase EIF2AK2 , IFN- type I-induced and dsRNA-activated kinase , IFN-induced and double-stranded RNA-activated kinase , T-cell viral integration site , dsRNA-activated kinase , eIF-2 alpha , eukaryotic translation initiation factor 2 alpha kinase 2 , protein kinase RNA-activated , protein kinase, interferon inducible double stranded RNA dependent , serine/threonine-protein kinase TIK , Protein kinase, interferon-inducible double stranded RNA dependent

GENE ID SPECIES
395147 Gallus gallus
459155 Pan troglodytes
611397 Canis lupus familiaris
708912 Macaca mulatta
100001092 Danio rerio
100009013 Oryctolagus cuniculus
100147679 Equus caballus
100173054 Pongo abelii
100579484 Nomascus leucogenys
5610 Homo sapiens
19106 Mus musculus
54287 Rattus norvegicus
Selected quality suppliers for anti-EIF2AK2 (EIF2AK2) Antibodies
Did you look for something else?