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Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) ELISA Kits

The protein encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. Additionally we are shipping EIF2AK2 Antibodies (269) and EIF2AK2 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
EIF2AK2 5610 P19525
EIF2AK2 19106 Q03963
EIF2AK2 54287 Q63184
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Top EIF2AK2 ELISA Kits at antibodies-online.com

Showing 3 out of 14 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.063 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 9 to 11 Days
$663.16
Details
Mouse < 0.78 U/L   96 Tests Log in to see 11 to 13 Days
$875.60
Details
Rat
0.312-20 ng/mL   96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for EIF2AK2 Interaction Partners

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. the expression of a Tat (show TAT ELISA Kits) construct containing mutations in the basic region (49-57aa), which is responsible for the interaction with PKR (show PKLR ELISA Kits), favored neither parasite growth nor IL-10 (show IL10 ELISA Kits) expression in infected macrophages.

  2. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL ELISA Kits) and HDAC8 (show HDAC8 ELISA Kits) mutations and PKR (show PKLR ELISA Kits) activation.

  3. The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 ELISA Kits), which is mediated by continual activation of PKR (show PKLR ELISA Kits) and degradation of PP1 (show PPA1 ELISA Kits).

  4. The sole essential function of cytomegalovirus TRS1 is to antagonize host PKR (show PKLR ELISA Kits).

  5. results show that ceramide acts at two distinct levels of the insulin (show INS ELISA Kits) signaling pathway (IRS1 (show IRS1 ELISA Kits) and Akt (show AKT1 ELISA Kits)). PKR (show PKLR ELISA Kits), which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS ELISA Kits) resistance in muscle cells.

  6. Classical swine fever virus (CSFV) infection increased the phosphorylation of eukaryotic translation initiation factor (show EIF2A ELISA Kits) (eIF)2alpha (show EIF2S1 ELISA Kits) and its kinase PKR (show PKLR ELISA Kits). The activation of PKR (show PKLR ELISA Kits) during CSFV infection is beneficial to the virus.

  7. these data indicate a pivotal role for PKR's protein-binding function on the proliferation of pancreatic beta cells through TRAF2 (show TRAF2 ELISA Kits)/RIP1/NF-kappaB (show NFKB1 ELISA Kits)/c-Myc (show MYC ELISA Kits) pathways.

  8. The results from this study indicate an important role of RAX (show RAX ELISA Kits)/PKR (show PKLR ELISA Kits) association in regulating PKR (show PKLR ELISA Kits) activity as well as ethanol neurotoxicity

  9. The G3BP1 (show G3BP1 ELISA Kits)-Caprin1-PKR (show PKLR ELISA Kits) complex represents a new mode of PKR (show PKLR ELISA Kits) activation and is important for antiviral activity of G3BP1 (show G3BP1 ELISA Kits) and PKR (show PKLR ELISA Kits) during infection with mengovirus.

  10. The data support a model in which activating RNAs induce formation of a back-to-back parallel PKR (show PKLR ELISA Kits) kinase dimer whereas nonactivating RNAs either fail to induce dimerization or produce an alternative, inactive dimer configuration.

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2) interaction partners

  1. This study provides insight into the molecular pathology of Cornelia de Lange syndrome by establishing a relationship between NIPBL (show NIPBL ELISA Kits) and HDAC8 (show HDAC8 ELISA Kits) mutations and PKR activation.

  2. Deletion of PKR does not affect HFD-induced obesity, hepatic steatosis or glucose metabolism, and only modestly affects adipose tissue inflammation.

  3. results show that ceramide acts at two distinct levels of the insulin (show INS ELISA Kits) signaling pathway (IRS1 (show IRS1 ELISA Kits) and Akt (show AKT1 ELISA Kits)). PKR, which is induced by both inflammation signals and ceramide, could play a major role in the development of insulin (show INS ELISA Kits) resistance in muscle cells.

  4. Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 ELISA Kits) R) functions as negative regulator of PKR/Eif2ak2 (protein kinase (show CDK7 ELISA Kits) R) in development of postnatal anterior pituitary tissue.

  5. Data indicate increasing expression of PKR during TNF-a (show TNF ELISA Kits)-induced osteoclast formation. Its inhibition prevents TNF-a (show TNF ELISA Kits)-induced bone destruction in vivo and can be then considered as new therapeutic target for bone disease.

  6. The authors show that Murine cytomegalovirus m142 and m143 knockout mutants attain organ titers equivalent to those attained by wild-type virus in Pkr knockout mice.

  7. these data indicate a pivotal role for PKR's protein-binding function on the proliferation of pancreatic beta cells through TRAF2 (show TRAF2 ELISA Kits)/RIP1 (show RALBP1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)/c-Myc (show MYC ELISA Kits) pathways.

  8. Activated PKR inhibits pancreatic beta-cell proliferation through sumoylation-dependent stabilization of P53 (show TP53 ELISA Kits).

  9. These data indicate that the association between PKR and TRBP integrates metabolism with translational control and inflammatory signaling and plays important roles in metabolic homeostasis and disease.

  10. The age-associated accumulation of somatic mutations that occurs in the Nup98 (show NUP98 ELISA Kits)-HOXD13 (show HOXD13 ELISA Kits) (NHD13) mouse model of leukemia progression was significantly elevated by co-expression of a PKR transgene.

EIF2AK2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.

Gene names and symbols associated with EIF2AK2

  • eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) antibody
  • eukaryotic translation initiation factor 2-alpha kinase 2 (eif2ak2) antibody
  • eukaryotic translation initiation factor 2-alpha kinase 2 (Eif2ak2) antibody
  • 2310047A08Rik antibody
  • 4732414G15Rik antibody
  • AI467567 antibody
  • AI747578 antibody
  • DKFZp469K1934 antibody
  • EIF2AK1 antibody
  • EIF2AK2 antibody
  • Pkr antibody
  • Prkr antibody
  • Tik antibody

Protein level used designations for EIF2AK2

double-stranded RNA-activated protein kinase , interferon-induced, double-stranded RNA-activated protein kinase , p68 kinase , P1/eIF-2A protein kinase , interferon-inducible RNA-dependent protein kinase , IFN-stimulated dsRNA-activated eIF2-alpha kinase 2 , double-stranded RNA activated protein kinase , eukaryotic translation initiation factor 2-alpha kinase 2 , double stranded RNA activated protein kinase , eIF-2A protein kinase 2 , interferon-inducible elF2alpha kinase , protein kinase, interferon-inducible double stranded RNA dependent , tyrosine-protein kinase EIF2AK2 , IFN- type I-induced and dsRNA-activated kinase , IFN-induced and double-stranded RNA-activated kinase , T-cell viral integration site , dsRNA-activated kinase , eIF-2 alpha , eukaryotic translation initiation factor 2 alpha kinase 2 , protein kinase RNA-activated , protein kinase, interferon inducible double stranded RNA dependent , serine/threonine-protein kinase TIK , Protein kinase, interferon-inducible double stranded RNA dependent

GENE ID SPECIES
395147 Gallus gallus
459155 Pan troglodytes
611397 Canis lupus familiaris
708912 Macaca mulatta
100001092 Danio rerio
100009013 Oryctolagus cuniculus
100147679 Equus caballus
100173054 Pongo abelii
100579484 Nomascus leucogenys
5610 Homo sapiens
19106 Mus musculus
54287 Rattus norvegicus
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