You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) Antibodies

The protein encoded by EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Additionally we are shipping PERK Kits (20) and PERK Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-PERK Antibodies at antibodies-online.com

Showing 10 out of 163 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB EIF2AK3 Antibody (N-term) (ABIN658472) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EIF2AK3 antibody detected the EIF2AK3 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PERK antibody (N-term Q163) (ABIN392617), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of PERK Antibody (N-term Q163) (ABIN392617) in 293 cell line lysates (35 µg/lane). PERK (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated IF, IHC (p), IP, WB 0.1 mL Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF (cc), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-Phospho-PERK(Thr980) Polyclonal Antibody, Unconjugated (ABIN744713) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded human lung carcinoma labeled with Anti-Phospho-PERK(Thr980) Polyclonal Antibody, Unconjugated (ABIN744713) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$291.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse stomach labeled with Anti-PERK Polyclonal Antibody, Unconjugated (ABIN740715) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Mouse Rabbit Un-conjugated IP, IHC, WB Western blot analysis using Immuno-chemical's anti-PERK to detect PERK in cell lysates. 300ug PERK over-expressing 293T cell lysate (lanes 1 & 2), or 800ug wild type (Lanes 3 & 4), and PERK knock out (lanes 5 & 6) MEF cell lysate were immunoprecipated with 15ul anti-PERK, followed by western bloting with 1:1000 dilution of anti-PERK in 5% milk/TBST buffer. Lane 1, 293T cells over-expressing Myc-PERK wt, Lane 2 , 293T cells over-expressing Myc-PERK K618A. 100 μL Log in to see 2 to 3 Days
$369.00
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using EIF2AK3 mAb against HEK293 (1) and EIF2AK3 (AA: 929-1116) -hIgGFc transfected HEK293 (2) cell lysate. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma, using PEK/PERK (Phospho-Thr981) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details

EIF2AK3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine) , , ,
,
,
, , , , , , , , , , ,
Rat (Rattus) , , ,
,

, , , , , , , , , , ,
Human , , , ,
, , ,
,
, , , , , , , , , , , , , ,

Top referenced anti-PERK Antibodies

  1. Mouse (Murine) Polyclonal PERK Primary Antibody for IF, IHC (p) - ABIN400976 : Harding, Zhang, Ron: Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. in Nature 1999 (PubMed)
    Show all 8 references for ABIN400976

  2. Human Polyclonal PERK Primary Antibody for IF (cc), IF (p) - ABIN744713 : He, Long, Zhong, Fu, Li, Lin: Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression. in Molecular and cellular biochemistry 2014 (PubMed)
    Show all 4 references for ABIN744713

  3. Human Polyclonal PERK Primary Antibody for EIA, IHC (p) - ABIN360502 : Delépine, Nicolino, Barrett, Golamaully, Lathrop, Julier: EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. in Nature genetics 2000 (PubMed)
    Show all 3 references for ABIN360502

  4. Human Monoclonal PERK Primary Antibody for ELISA, WB - ABIN969093 : Yamaguchi, Larkin, Lara-Lemus, Ramos-Castañeda, Liu, Arvan: Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK. in The Journal of biological chemistry 2008 (PubMed)
    Show all 2 references for ABIN969093

  5. Human Polyclonal PERK Primary Antibody for IHC (p), WB - ABIN658472 : Kim, Moretti, Mitchell, Jung, Lu: Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells. in Oncogene 2010 (PubMed)
    Show all 2 references for ABIN658472

  6. Mouse (Murine) Polyclonal PERK Primary Antibody for IP, IHC - ABIN233768 : Huang, Wu, Chen, Hong: Aquatic birnavirus-induced ER stress-mediated death signaling contribute to downregulation of Bcl-2 family proteins in salmon embryo cells. in PLoS ONE 2011 (PubMed)

  7. Human Polyclonal PERK Primary Antibody for IHC (p), WB - ABIN392617 : Nakayama, Endo, Tsukano, Mori, Oike, Gotoh: Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP pathway. in Journal of biochemistry 2010 (PubMed)

More Antibodies against PERK Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. PlGF (show PGF Antibodies) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A Antibodies) via vessel normalisation. The UPR is able to regulate PlGF (show PGF Antibodies) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR

  2. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 Antibodies), in tubule cell production of fibronectin (show FN1 Antibodies)

  3. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

  4. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  5. Results show that PERK-eIF2alpha (show EIF2A Antibodies)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau

  6. whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 Antibodies) protein levels and signaling in pancreatic tissues.

  7. PGRN (show GRN Antibodies) is a key regulator of insulin (show INS Antibodies) resistance and PGRN (show GRN Antibodies) may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2alpha (show EIF2A Antibodies) dependent pathway

  8. findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes

  9. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

  10. interface mutations that disrupt tetramer formation in vitro reduce phosphorylation of PERK and its target eIF2alpha (show EIF2A Antibodies) in cells.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  2. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Antibodies) formation upstream of AMP-activated protein kinase (show PRKAA2 Antibodies) and protein kinase (show CDK7 Antibodies) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Antibodies) pathways and p21 Cip1 (show CDKN1A Antibodies) expression.

  3. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  4. Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]

  5. CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK/CHOP (show DDIT3 Antibodies) signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.

  6. Data indicated that the relative timing of IRE1 and PERK signalling determines the shift from cell survival to apoptosis.

  7. In human alveolar epithelial A549 cells, Lipopolysaccharide induces autophagic cell death that depends on the activation of the PERK branch of the unfolded protein response upon endoplasmic reticulum (ER) stress .

  8. In this review, we particularly focused on the novel, intriguing and complicated role of PERK in ER stress-decided cell fate, and also discussed more roles of PERK in restoring cellular homeostasis

  9. This study demonstrates a new role for CREB (show CREB1 Antibodies) as a regulator of ER stress, which is required to properly respond to stressful conditions, such as hypoxia.

  10. PERK-activated osteosarcomatous autophagy via inhibition of the mTORC1 pathway prevents cell apoptosis.

PERK (EIF2AK3) Antigen Profile

Protein Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Gene names and symbols associated with EIF2AK3

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3) antibody
  • AI427929 antibody
  • EIF2AK3 antibody
  • PEK antibody
  • PERK antibody
  • WRS antibody

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
Selected quality suppliers for anti-PERK (EIF2AK3) Antibodies
Did you look for something else?