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Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) ELISA Kits

The protein encoded by EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Additionally we are shipping PERK Antibodies (158) and PERK Proteins (10) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5
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Top PERK ELISA Kits at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.108 ng/mL 0.31-20 ng/mL 96 Tests Log in to see 9 to 11 Days
$757.89
Details
Human 0.1 ng/mL   96 Tests Log in to see 11 to 13 Days
$785.71
Details
Rabbit
  96 Tests Log in to see 11 to 13 Days
$785.71
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Guinea Pig
  96 Tests Log in to see 11 to 13 Days
$801.43
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Goat
  96 Tests Log in to see 11 to 13 Days
$801.43
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Dog
  96 Tests Log in to see 11 to 13 Days
$801.43
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Monkey
  96 Tests Log in to see 11 to 13 Days
$817.14
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Human
  96 Tests Log in to see 2 to 3 Days
$380.00
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Rat
  96 Tests Log in to see 11 to 13 Days
$1,029.60
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Pig
  96 Tests Log in to see 5 to 9 Days
$660.90
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More ELISA Kits for PERK Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. PlGF (show PGF ELISA Kits) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A ELISA Kits) via vessel normalisation. The UPR is able to regulate PlGF (show PGF ELISA Kits) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR

  2. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 ELISA Kits), in tubule cell production of fibronectin (show FN1 ELISA Kits)

  3. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

  4. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  5. Results show that PERK-eIF2alpha (show EIF2A ELISA Kits)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau

  6. whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 ELISA Kits) protein levels and signaling in pancreatic tissues.

  7. PGRN (show GRN ELISA Kits) is a key regulator of insulin (show INS ELISA Kits) resistance and PGRN (show GRN ELISA Kits) may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2alpha (show EIF2A ELISA Kits) dependent pathway

  8. findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes

  9. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

  10. interface mutations that disrupt tetramer formation in vitro reduce phosphorylation of PERK and its target eIF2alpha (show EIF2A ELISA Kits) in cells.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  2. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B ELISA Kits) formation upstream of AMP-activated protein kinase (show PRKAA2 ELISA Kits) and protein kinase (show CDK7 ELISA Kits) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 ELISA Kits) pathways and p21 Cip1 (show CDKN1A ELISA Kits) expression.

  3. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  4. Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]

  5. CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK/CHOP (show DDIT3 ELISA Kits) signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.

  6. Data indicated that the relative timing of IRE1 and PERK signalling determines the shift from cell survival to apoptosis.

  7. In human alveolar epithelial A549 cells, Lipopolysaccharide induces autophagic cell death that depends on the activation of the PERK branch of the unfolded protein response upon endoplasmic reticulum (ER) stress .

  8. In this review, we particularly focused on the novel, intriguing and complicated role of PERK in ER stress-decided cell fate, and also discussed more roles of PERK in restoring cellular homeostasis

  9. This study demonstrates a new role for CREB (show CREB1 ELISA Kits) as a regulator of ER stress, which is required to properly respond to stressful conditions, such as hypoxia.

  10. PERK-activated osteosarcomatous autophagy via inhibition of the mTORC1 pathway prevents cell apoptosis.

PERK (EIF2AK3) Antigen Profile

Antigen Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Gene names and symbols associated with EIF2AK3

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) antibody
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3) antibody
  • AI427929 antibody
  • EIF2AK3 antibody
  • PEK antibody
  • PERK antibody
  • WRS antibody

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
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