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The protein encoded by EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Additionally we are shipping PERK Antibodies (160) and PERK Kits (20) and many more products for this protein.
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Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.
Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.
Results show that PERK-eIF2alpha (show EIF2A Proteins)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau
whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 Proteins) protein levels and signaling in pancreatic tissues.
PGRN (show GRN Proteins) is a key regulator of insulin (show INS Proteins) resistance and PGRN (show GRN Proteins) may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2alpha (show EIF2A Proteins) dependent pathway
findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes
ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation
interface mutations that disrupt tetramer formation in vitro reduce phosphorylation of PERK and its target eIF2alpha (show EIF2A Proteins) in cells.
Neoplastic de-differentiation confers multidrug resistance via non-canonical PERK-Nrf2 (show NFE2L2 Proteins) signaling.
It mediates eIF2alpha (show EIF2A Proteins) phosphorylation responsible for BACE1 (show BACE Proteins) elevation, CREB (show CREB1 Proteins) dysfunction and neurodegeneration in Alzheimer's disease.
Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Proteins) pathways and p21 Cip1 (show CDKN1A Proteins) expression.
Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]
CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK/CHOP (show DDIT3 Proteins) signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.
Data indicated that the relative timing of IRE1 and PERK signalling determines the shift from cell survival to apoptosis.
In human alveolar epithelial A549 cells, Lipopolysaccharide induces autophagic cell death that depends on the activation of the PERK branch of the unfolded protein response upon endoplasmic reticulum (ER) stress .
In this review, we particularly focused on the novel, intriguing and complicated role of PERK in ER stress-decided cell fate, and also discussed more roles of PERK in restoring cellular homeostasis
This study demonstrates a new role for CREB (show CREB1 Proteins) as a regulator of ER stress, which is required to properly respond to stressful conditions, such as hypoxia.
PERK-activated osteosarcomatous autophagy via inhibition of the mTORC1 pathway prevents cell apoptosis.
Our results reveal that PERK activation is involved in glioma glycolysis regulation and may be a potential molecular target for glioma treatment.
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
eukaryotic translation initiation factor 2-alpha kinase 3
, eukaryotic translation initiation factor 2-alpha kinase 3-like
, PRKR-like endoplasmic reticulum kinase
, pancreatic eIF2-alpha kinase
, eukaryotic translation initiation factor 2 alpha kinase 3
, pancreatic EIF2-alpha kinase