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Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 Proteins (EIF2AK3)

The protein encoded by EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Additionally we are shipping PERK Antibodies (163) and PERK Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF2AK3 13666  
EIF2AK3 29702 Q9Z1Z1
EIF2AK3 9451 Q9NZJ5
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Top PERK Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

EIF2AK3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Rat (Rattus)
Human , , ,
, ,

More Proteins for Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. PlGF (show PGF Proteins) inhibition attenuates PERK activation, likely by tempering hypoxia in HCC (show FAM126A Proteins) via vessel normalisation. The UPR is able to regulate PlGF (show PGF Proteins) expression, suggesting the existence of a feedback mechanism for hypoxia-mediated UPR

  2. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK and a downstream effector of its activation, CHOP (show DDIT3 Proteins), in tubule cell production of fibronectin (show FN1 Proteins)

  3. Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses.

  4. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  5. Results show that PERK-eIF2alpha (show EIF2A Proteins)-mediated translational failure is a key process leading to neuronal loss in a mouse model of frontotemporal dementia, where the misfolded protein is a form of mutant tau

  6. whole-body or pancreas-specific Perk ablation in mice leads to an increase in IFNAR1 (show IFNAR1 Proteins) protein levels and signaling in pancreatic tissues.

  7. PGRN (show GRN Proteins) is a key regulator of insulin (show INS Proteins) resistance and PGRN (show GRN Proteins) may mediate its effects, at least in part, by inducing ER stress via the PERK-eIF2alpha (show EIF2A Proteins) dependent pathway

  8. findings suggest that palmitate increases musclin gene expression via the activation of the PERK signaling pathway in C2C12 myotubes

  9. ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation

  10. interface mutations that disrupt tetramer formation in vitro reduce phosphorylation of PERK and its target eIF2alpha (show EIF2A Proteins) in cells.

Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) interaction partners

  1. Using drugs that specifically inhibit or activate the PERK or IRE1alpha sensors, we demonstrate that signalling through the PERK axis activates this expression, through a transcriptional mechanism

  2. Data show CGK733 induced microtubule associated protein LC3B (show MAP1LC3B Proteins) formation upstream of AMP-activated protein kinase (show PRKAA2 Proteins) and protein kinase (show CDK7 Proteins) RNA-like endoplasmic reticulum kinase/CCAAT-enhancer-binding protein homologous protein (show DDIT3 Proteins) pathways and p21 Cip1 (show CDKN1A Proteins) expression.

  3. Nitric oxide can S-nitrosylate the endoplasmic reticulum stress sensors IRE1alapha and PERK.

  4. Data from 2 consanguineous families suggest EIF2AK3 mutations (c.1337_1338insT/p.K346*; c.3009C>T/p.R903*) account for Wolcott-Rallison syndrome; ultrastructural features of autopsy materials suggest endoplasmic reticulum dysfunction. [CASE STUDIES]

  5. CGK733-induced intracellular calcium sequestration in pancreatic tumor cells is correlated with the PERK/CHOP (show DDIT3 Proteins) signaling pathway and may also be involved in the dysregulations of calcium-binding proteins.

  6. Data indicated that the relative timing of IRE1 and PERK signalling determines the shift from cell survival to apoptosis.

  7. In human alveolar epithelial A549 cells, Lipopolysaccharide induces autophagic cell death that depends on the activation of the PERK branch of the unfolded protein response upon endoplasmic reticulum (ER) stress .

  8. In this review, we particularly focused on the novel, intriguing and complicated role of PERK in ER stress-decided cell fate, and also discussed more roles of PERK in restoring cellular homeostasis

  9. This study demonstrates a new role for CREB (show CREB1 Proteins) as a regulator of ER stress, which is required to properly respond to stressful conditions, such as hypoxia.

  10. PERK-activated osteosarcomatous autophagy via inhibition of the mTORC1 pathway prevents cell apoptosis.

PERK (EIF2AK3) Protein Profile

Protein Summary

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Gene names and symbols associated with EIF2AK3

  • eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
  • eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3)
  • AI427929 protein
  • EIF2AK3 protein
  • PEK protein
  • PERK protein
  • WRS protein

Protein level used designations for EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3 , eukaryotic translation initiation factor 2-alpha kinase 3-like , PRKR-like endoplasmic reticulum kinase , pancreatic eIF2-alpha kinase , eukaryotic translation initiation factor 2 alpha kinase 3 , hsPEK , pancreatic EIF2-alpha kinase

GENE ID SPECIES
459388 Pan troglodytes
475756 Canis lupus familiaris
699575 Macaca mulatta
100029557 Monodelphis domestica
100066488 Equus caballus
100394186 Callithrix jacchus
100447385 Pongo abelii
100479743 Ailuropoda melanoleuca
13666 Mus musculus
29702 Rattus norvegicus
9451 Homo sapiens
535820 Bos taurus
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