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EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008].. Additionally we are shipping EIF2A Kits (4) and many more products for this protein.
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Human Polyclonal EIF2A Primary Antibody for IF, IHC - ABIN362446
Korpelainen, Kärkkäinen, Gunji, Vikkula, Alitalo: Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. in Oncogene 1999
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Human Polyclonal EIF2A Primary Antibody for IF, IHC - ABIN362970
Saelens, Kalai, Vandenabeele: Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation. in The Journal of biological chemistry 2001
Show all 2 references for ABIN362970
Human Polyclonal EIF2A Primary Antibody for IF, IHC - ABIN362356
Kubota, Obata, Ota, Sasaki, Ito: Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. in The Journal of biological chemistry 2003
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Human Polyclonal EIF2A Primary Antibody for IF (p), IHC (p) - ABIN1714407
He, Long, Zhong, Fu, Li, Lin: Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression. in Molecular and cellular biochemistry 2014
The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Skeletal muscle-specific (show EIF3K Antibodies) eukaryotic translation initiation factor 2alpha (show EIF2S1 Antibodies) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (show FGF21 Antibodies)-mediated non-cell-autonomous energy metabolism.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
PGRN (show GRN Antibodies) is a key regulator of insulin (show INS Antibodies) resistance and PGRN (show GRN Antibodies) may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 Antibodies)-eIF2alpha dependent pathway
The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha-ATF4 (show ATF4 Antibodies) axis and to develop drugs targeting this important pathway in the remediation of related pathologies.
Data indicate that 5xFAD-related pathologies do not necessarily require hyperphosphorylation of eIF2alpha to emerge.
Endoplasmic reticulum stress suppressed CReP (show PPP1R15B Antibodies) expression in an IRE1 alpha (show ERN1 Antibodies)-dependent manner, which increased eIF2alpha phosphorylation and consequently attenuated protein synthesis.
eIF2alphaP acts as a molecular switch that dictates either cell survival or death by activated Akt (show AKT1 Antibodies) in response to oxidative stress.
inhibition of eIF2alpha and FAK (show PTK2 Antibodies) signaling may play an important role in cigarette smoking-induced lung EC apoptosis and emphysema
eIF2a phosphorylation is required for the normal function of intestinal Paneth cells and mucosal homeostasis.
aberrant phosphorylation of eukaryotic initiation factor (show EIF4G1 Antibodies)-2a (eIF2a) may induce synaptic failure and neurodegeneration through persistent translational inhibition of global protein synthesis.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 Antibodies), which is mediated by continual activation of PKR (show PKLR Antibodies) and degradation of PP1 (show PPA1 Antibodies).
We identified EIF2A (show EIF2S1 Antibodies) phosphorylation as a novel early molecular event occurring in response to NAMPT (show NAMPT Antibodies) inhibition and mediating protein synthesis arrest.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (show PPA1 Antibodies) and eIF2alpha with GADD34 (show PPP1R15A Antibodies), demonstrating that GADD34 (show PPP1R15A Antibodies) functions as a scaffold both in vitro and in cells
hypusine-eIF5A (show EIF5 Antibodies)-facilitated translation elongation promotes arsenite-induced polysome disassembly and stress granule assembly in cells subjected to adverse environmental conditions
There was no statistically significant difference in IFN therapeutic effectiveness among the patients with different genotypes of eIF-2a (show EIF2S1 Antibodies)-reg2 (show FLOT1 Antibodies).
ABC50 (show ABCF1 Antibodies) N-terminal region interacts with eukaryotic initiation factor (show EIF4G1 Antibodies) eIF2 (show EIF2S1 Antibodies) and is a target for regulatory phosphorylation by CK2 (show CSNK2A1 Antibodies)
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, eukaryotic translation initiation factor 2A
, Eukaryotic translation initiation factor 2A
, 65 kDa eukaryotic translation initiation factor 2A
, GTP-exchange protein
, eIF-2B GDP-GTP exchange factor subunit alpha
, translation initiation factor eIF-2B subunit alpha