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Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa Proteins (EIF2B1)

EIF2B1 encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Additionally we are shipping Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF2B1 209354 Q99LC8
EIF2B1 64514 Q64270
EIF2B1 1967 Q14232
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Top Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa Proteins at antibodies-online.com

Showing 9 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,812.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,812.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,812.33
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,812.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$364.64
Details

EIF2B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

Top referenced Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa Proteins

  1. Human EIF2B1 Protein expressed in Escherichia coli (E. coli) - ABIN667427 : Mohammad-Qureshi, Haddad, Hemingway, Richardson, Pavitt: Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange. in Molecular and cellular biology 2007 (PubMed)
    Show all 2 references for ABIN667427

More Proteins for Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) Interaction Partners

Mouse (Murine) Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) interaction partners

  1. These are the first data that mechanistically link eIF2Bepsilon (show EIF2B5 Proteins) abundance to skeletal myofibre hypertrophy.

  2. A point mutation in translation initiation factor (show TIF1 Proteins) eIF2B (show EIF2B4 Proteins) leads to Vanishing White Matter disease.

  3. Inhibition of pancreatic protein synthesis in this model of acute pancreatitis most likely results from inhibition of translation initiation from increased eIF2alpha (show EIF2A Proteins) phosphorylation, reduction of eIF2B (show EIF2B4 Proteins) activity, and inhibition of eIF4F (show EIF4A2 Proteins) complex formation.

Human Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) interaction partners

  1. Oligodendrocytes with truncated or deletion mutants eIF2B showed less tolerable to endoplasmic reticulum stress

  2. These data emphasize the importance of eIF2Balpha in mediating the eIF2 (show EIF2S1 Proteins) kinase translation-inhibitory activity and may provide insight into the complex nature of vesiculovirus oncolysis.

  3. mutational analysis of the eIF2B genes of patients with an antenatal- or early-infantile-onset encephalopathy and an early demise

  4. Biochemical analyses indicate that mutations analyzed in eIF2Balpha and -epsilon reduce the steady-state level of the affected subunit, while the most severe mutant tested, eIF2Bbeta(V341D), forms complexes with reduced stability and lower eIF2B activity.

  5. analysis of novel mutations in patients with eIF2B-related disorders

  6. Study reports 9 novel mutations in EIF2B genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B protein (alpha, beta, gamma, delta, epsilon)

  7. The authors suspected VWM and sequenced the genes EIF2B1-5, which revealed one heterozygous mutation in EIF2B4 (show EIF2B4 Proteins).

  8. Crystal structure of the alpha subunit (show POLG Proteins) of human translation initiation factor (show TIF1 Proteins) 2B.

Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa (EIF2B1) Protein Profile

Protein Summary

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter.

Gene names and symbols associated with EIF2B1

  • translation initiation factor eIF-2B alpha subunit (eIF2b1)
  • translation initiation factor eIF-2B subunit alpha (PGTG_05021)
  • Translation initiation factor eIF-2B subunit alpha (ei2ba)
  • translation initiation factor eif-2b subunit alpha (ei2ba)
  • eukaryotic translation initiation factor 2B, subunit 1 (alpha) (Eif2b1)
  • eukaryotic translation initiation factor 2B, subunit 1 alpha (Eif2b1)
  • eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa (EIF2B1)
  • 26kDa protein
  • D5Ertd406e protein
  • DDBDRAFT_0219393 protein
  • DDBDRAFT_0231375 protein
  • DDB_0219393 protein
  • DDB_0231375 protein
  • eIF-2a protein
  • EIF2B protein
  • EIF2BA protein

Protein level used designations for EIF2B1

translation initiation factor eIF-2B subunit alpha , Translation initiation factor eIF-2B subunit alpha , translation initiation factor eif-2b subunit alpha , eIF-2B GDP-GTP exchange factor subunit alpha , eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kDa) , GTP-exchange protein , eIF-2Balpha

GENE ID SPECIES
8626881 Dictyostelium discoideum AX4
10530886 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100305173 Oncorhynchus mykiss
100528837 Ictalurus punctatus
209354 Mus musculus
64514 Rattus norvegicus
1967 Homo sapiens
516670 Bos taurus
100172592 Pongo abelii
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