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The protein encoded by EIF2B3 is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Additionally we are shipping EIF2B3 Antibodies (61) and EIF2B3 Proteins (6) and many more products for this protein.
To determine the tolerance differences to ERS, cell viability and apoptosis rates were detected in oligodendrocyte cell lines transfected with EIF2B3-c.1037T>C or the wild type. We confirmed that oligodendrocytes with mutant EIF2B3 was less tolerant to ERS than the wild type, with decreased cell viability and increased apoptosis rates.
Results show significant higher incidence of Chinese patients with EIF2B3 mutations compared with Caucasian patients. The c.1037T>C in EIF2B3 was confirmed to be a founder mutation in Chinese explaining the genotypic differences between ethnicities.
Study reports 9 novel mutations in EIF2B (show EIF2B1 ELISA Kits) genes in 8 patients, increasing number of known mutations to more than 120. Using homology modeling, analyzed the impact of novel mutations on the 5 subunits of eIF2B (show EIF2B1 ELISA Kits) protein (alpha, beta, gamma, delta, epsilon)
The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
eukaryotic translation initiation factor 2B, subunit 3 gamma
, translation initiation factor eIF-2B subunit gamma
, eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
, Translation initiation factor eIF-2B subunit gamma-like protein
, eIF2B-gamma protein
, translation initiation factor eIF-2B subunit gamma-like
, eIF-2B GDP-GTP exchange factor subunit gamma
, eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD)