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The protein encoded by EIF4G1 is a component of the multi-subunit protein complex EIF4F. Additionally we are shipping Eukaryotic Translation Initiation Factor 4 Gamma, 1 Proteins (9) and many more products for this protein.
Showing 10 out of 133 products:
Human Polyclonal EIF4G1 Primary Antibody for IP, WB - ABIN151736
Escobar, Frank, Suryawan, Nguyen, Davis: Amino acid availability and age affect the leucine stimulation of protein synthesis and eIF4F formation in muscle. in American journal of physiology. Endocrinology and metabolism 2007
Show all 25 references for ABIN151736
Human Polyclonal EIF4G1 Primary Antibody for IF, IHC - ABIN363084
Piirsoo, Ustav, Mandel, Stenlund, Ustav: Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator. in The EMBO journal 1996
Show all 4 references for ABIN363084
Human Polyclonal EIF4G1 Primary Antibody for IHC, WB - ABIN362450
De Gregorio, Preiss, Hentze: Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent. in RNA (New York, N.Y.) 1998
Show all 4 references for ABIN362450
Human Polyclonal EIF4G1 Primary Antibody for IHC (p), WB - ABIN319277
Borman, Kean: Intact eukaryotic initiation factor 4G is required for hepatitis A virus internal initiation of translation. in Virology 1997
Show all 3 references for ABIN319277
Human Polyclonal EIF4G1 Primary Antibody for IF, IHC (p) - ABIN319387
Gradi, Imataka, Svitkin, Rom, Raught, Morino, Sonenberg: A novel functional human eukaryotic translation initiation factor 4G. in Molecular and cellular biology 1998
Show all 3 references for ABIN319387
Human Polyclonal EIF4G1 Primary Antibody for WB - ABIN2778919
Ramírez-Valle, Braunstein, Zavadil, Formenti, Schneider: eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. in The Journal of cell biology 2008
Phosphorylation of 4E-BP1 (show EIF4EBP1 Antibodies) impairs the competition with eIF4G for eIF4E (show EIF4E Antibodies) binding.
The eIF4G knockdown did not affect male fertility.
Data show that in the early embryo dFMRP (show FMR1 Antibodies) associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.
A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.
coordinated and selective recruitment of eIF4E (show EIF4E Antibodies) and eIF4G factors at a very early step in potyvirus infection
EIF4G1 mutations are not related to Parkinson's disease
VPS35 (show vps35 Antibodies) D620N and EIF4G1 R1205H mutations are not a common cause of Parkinson disease in the Greek population.
This study is the first to directly assess the relative contribution of eIF4F (show EIF4A2 Antibodies) components to the expressed cellular proteome, transcription factors, microRNAs, and phenotype in multiple myeloma
EIF4GI shares this activity and also interacts with eIF1 (show EIF1 Antibodies).
the C-terminal extension (motif 3) is critical to 4E-BP1 (show EIF4EBP1 Antibodies)-mediated cell cycle arrest and it partially overlaps with the binding site of 4EGI-1
EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.
This study therefore implicates c-Myc (show MYC Antibodies) as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes
Knockdown of eIF4GI was deleterious to myeloma cells phenotype and expression of specific molecular targets (SMAD5 (show SMAD5 Antibodies)/ERalpha (show ESR1 Antibodies)/HIF1alpha (show HIF1A Antibodies)/c-Myc (show MYC Antibodies)).
in a generic cell model, new insights into the mechanisms whereby the FSH receptor (show FSHR Antibodies) controls translation have been gained. Rapamycin-sensitive eIF4G phosphorylation at the 5' cap may be a surrogate for the classical exchange between eIF4G and 4E-BP1 (show EIF4EBP1 Antibodies).
The results of this study did not identify novel or previously reported pathogenic mutations (including the p.A502V and p.R1205H mutants) within EIF4G1 in the Japanese population.
Our studies reveal unexpected genetic and functional interactions between VPS35 (show vps35 Antibodies) and EIF4G1, two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein (show SNCA Antibodies) pathobiology in yeast, worms, and mouse.
Disruption of insulin receptor (IR (show INSR Antibodies)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE (show CPE Antibodies)) by inhibition of the eukaryotic translation initiation factor (show EIF2A Antibodies) Eif4g1.
Data indicate that MNK2 (show MKNK2 Antibodies) plays a unique role, not shared by its closest paralog MNK1 (show MKNK1 Antibodies), in limiting protein translation through its negative effect on eIF4G Ser1108 phosphorylation and p70S6K (show RPS6KB1 Antibodies) activation.
expression of 3e5 diminishes eIF4G interaction with eIF3 (show EIF3A Antibodies) and causes abnormal gene expression at the translational level.
findings assign NAD(P)H (show NQO1 Antibodies) quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome.
downregulated expression in T cells following treatment with bis (show BAG3 Antibodies)(tri (show VANGL2 Antibodies)-n-butylin)oxide (TBTO), an immunotoxic organotin compound
eIF4G binding to Mnk (show ATP7A Antibodies) is inhibted by Mnk1 (show MKNK1 Antibodies) phosphorylation by caspase (show CASP3 Antibodies)-activated Pak2/gamma-PAK (show PAK2 Antibodies)
Comparison of the p53 (show TP53 Antibodies)-induced patterns of eIF4GI and 4E-BP1 (show EIF4EBP1 Antibodies) dephosphorylation and cleavage with those caused by the mammalian target of rapamycin (show FRAP1 Antibodies) inhibitor rapamycin
These findings suggest that the ability of cells to rephosphorylate 4E-BP1 (show EIF4EBP1 Antibodies), resynthesise eIF4GI and restore the rate of protein synthesis after inactivation of p53 (show TP53 Antibodies) is an important aspect of recovery following the relief of physiological stress.
interactions between Pdcd4 (show PDCD4 Antibodies) and components of the translation initiation complex, namely, the RNA helicase eIF4A (show EIF4A1 Antibodies) and the scaffolding protein eIF4G
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
eukaryotic translation initiation factor 4 gamma 1
, eukaryotic initiation factor 4G
, translation initiation factor
, translation initiation factor eIF4G
, eukaryotic translation initiation factor 4 gamma, 1
, eukaryotic initiation factor
, eukaryotic translation initiation factor 4 gamma
, eukaryotic translation initiation factor 4 gamma 1-like
, eIF-4-gamma 1
, eucaryotic translation initiation factor 4G
, eIF-4G 1