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Eukaryotic Translation Initiation Factor 4 Gamma, 1 Proteins (EIF4G1)

The protein encoded by EIF4G1 is a component of the multi-subunit protein complex EIF4F. Additionally we are shipping Eukaryotic Translation Initiation Factor 4 Gamma, 1 Antibodies (132) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4G1 1981 Q04637
Rat EIF4G1 EIF4G1 287986  
EIF4G1 208643 Q6NZJ6
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Top Eukaryotic Translation Initiation Factor 4 Gamma, 1 Proteins at antibodies-online.com

Showing 5 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 6 to 7 Days
$444.68
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HOST_Human Human Un-conjugated   20 μg Log in to see 19 Days
$785.40
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EIF4G1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced Eukaryotic Translation Initiation Factor 4 Gamma, 1 Proteins

  1. Human EIF4G1 Protein expressed in Wheat germ - ABIN1352615 : Arif, Jia, Mukhopadhyay, Willard, Kinter, Fox: Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. in Molecular cell 2009 (PubMed)

More Proteins for Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. Phosphorylation of 4E-BP1 (show EIF4EBP1 Proteins) impairs the competition with eIF4G for eIF4E (show EIF4E Proteins) binding.

  2. The eIF4G knockdown did not affect male fertility.

  3. Data show that in the early embryo dFMRP (show FMR1 Proteins) associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.

  4. A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.

Arabidopsis thaliana Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. coordinated and selective recruitment of eIF4E (show EIF4E Proteins) and eIF4G factors at a very early step in potyvirus infection

Human Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. EIF4G1 mutations are not related to Parkinson's disease

  2. VPS35 (show vps35 Proteins) D620N and EIF4G1 R1205H mutations are not a common cause of Parkinson disease in the Greek population.

  3. This study is the first to directly assess the relative contribution of eIF4F (show EIF4A2 Proteins) components to the expressed cellular proteome, transcription factors, microRNAs, and phenotype in multiple myeloma

  4. EIF4GI shares this activity and also interacts with eIF1 (show EIF1 Proteins).

  5. the C-terminal extension (motif 3) is critical to 4E-BP1 (show EIF4EBP1 Proteins)-mediated cell cycle arrest and it partially overlaps with the binding site of 4EGI-1

  6. EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.

  7. This study therefore implicates c-Myc (show MYC Proteins) as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes

  8. Knockdown of eIF4GI was deleterious to myeloma cells phenotype and expression of specific molecular targets (SMAD5 (show SMAD5 Proteins)/ERalpha (show ESR1 Proteins)/HIF1alpha (show HIF1A Proteins)/c-Myc (show MYC Proteins)).

  9. in a generic cell model, new insights into the mechanisms whereby the FSH receptor (show FSHR Proteins) controls translation have been gained. Rapamycin-sensitive eIF4G phosphorylation at the 5' cap may be a surrogate for the classical exchange between eIF4G and 4E-BP1 (show EIF4EBP1 Proteins).

  10. The results of this study did not identify novel or previously reported pathogenic mutations (including the p.A502V and p.R1205H mutants) within EIF4G1 in the Japanese population.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) interaction partners

  1. Our studies reveal unexpected genetic and functional interactions between VPS35 and EIF4G1, two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.

  2. Disruption of insulin receptor (IR (show INSR Proteins)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE (show CPE Proteins)) by inhibition of the eukaryotic translation initiation factor (show EIF2A Proteins) Eif4g1.

  3. Data indicate that MNK2 (show MKNK2 Proteins) plays a unique role, not shared by its closest paralog MNK1 (show MKNK1 Proteins), in limiting protein translation through its negative effect on eIF4G Ser1108 phosphorylation and p70S6K (show RPS6KB1 Proteins) activation.

  4. expression of 3e5 diminishes eIF4G interaction with eIF3 (show EIF3A Proteins) and causes abnormal gene expression at the translational level.

  5. findings assign NAD(P)H (show NQO1 Proteins) quinone-oxydoreductase 1 an original role in the regulation of mRNA translation via the control of eIF4GI stability by the proteasome.

  6. downregulated expression in T cells following treatment with bis (show BAG3 Proteins)(tri (show VANGL2 Proteins)-n-butylin)oxide (TBTO), an immunotoxic organotin compound

  7. eIF4G binding to Mnk (show ATP7A Proteins) is inhibted by Mnk1 (show MKNK1 Proteins) phosphorylation by caspase (show CASP3 Proteins)-activated Pak2/gamma-PAK (show PAK2 Proteins)

  8. Comparison of the p53 (show TP53 Proteins)-induced patterns of eIF4GI and 4E-BP1 (show EIF4EBP1 Proteins) dephosphorylation and cleavage with those caused by the mammalian target of rapamycin (show FRAP1 Proteins) inhibitor rapamycin

  9. These findings suggest that the ability of cells to rephosphorylate 4E-BP1 (show EIF4EBP1 Proteins), resynthesise eIF4GI and restore the rate of protein synthesis after inactivation of p53 (show TP53 Proteins) is an important aspect of recovery following the relief of physiological stress.

  10. interactions between Pdcd4 (show PDCD4 Proteins) and components of the translation initiation complex, namely, the RNA helicase eIF4A (show EIF4A1 Proteins) and the scaffolding protein eIF4G

Eukaryotic Translation Initiation Factor 4 Gamma, 1 (EIF4G1) Protein Profile

Protein Summary

The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.

Gene names and symbols associated with EIF4G1

  • eukaryotic translation initiation factor 4 gamma, 1 (EIF4G1)
  • eukaryotic translation initiation factor 4G (eIF4G)
  • zgc:158450 (zgc:158450)
  • eukaryotic translation initiation factor 4 gamma, 1 (eif4g1)
  • eukaryotic translation initiation factor 4G (EIF4G)
  • eukaryotic initiation factor (EIF4G)
  • eukaryotic translation initiation factor 4 gamma (eIF4g)
  • eukaryotic translation initiation factor 4 gamma (Eif4g)
  • eukaryotic translation initiation factor 4 gamma, 1 (Eif4g1)
  • eukaryotic translation initiation factor 4, gamma 1 (Eif4g1)
  • CG10811 protein
  • CUCUMOVIRUS MULTIPLICATION 2 protein
  • CUM2 protein
  • DDBDRAFT_0217646 protein
  • DDBDRAFT_0217647 protein
  • DDBDRAFT_0234257 protein
  • DDB_0217646 protein
  • DDB_0217647 protein
  • DDB_0234257 protein
  • deIF4G protein
  • Dmel\\CG10811 protein
  • E030015G23Rik protein
  • eIF-4G protein
  • EIF-4G1 protein
  • EIF4F protein
  • eif4g protein
  • EIF4G1 protein
  • eIF4GI protein
  • eukaryotic translation initiation factor 4G protein
  • NV18824 protein
  • p200 protein
  • p220 protein
  • PARK18 protein
  • wu:fb50a05 protein
  • wu:fc60b06 protein

Protein level used designations for EIF4G1

eukaryotic translation initiation factor 4 gamma 1 , CG10811-PA , CG10811-PB , CG10811-PC , Eukaryotic-initiation-factor-4G , eIF-4G , eIF4G-PA , eIF4G-PB , eIF4G-PC , eukaryotic initiation factor 4G , translation initiation factor , translation initiation factor eIF4G , eukaryotic translation initiation factor 4 gamma, 1 , fb50a05 , eukaryotic initiation factor , eukaryotic translation initiation factor 4 gamma , eukaryotic translation initiation factor 4 gamma 1-like , EIF4-gamma , eIF-4-gamma 1 , eucaryotic translation initiation factor 4G , eIF-4G 1 , eIF-4G1

GENE ID SPECIES
449528 Sus scrofa
100033975 Equus caballus
43839 Drosophila melanogaster
424953 Gallus gallus
460888 Pan troglodytes
572435 Danio rerio
704923 Macaca mulatta
733162 Xenopus laevis
825194 Arabidopsis thaliana
5718605 Chlamydomonas reinhardtii
8246969 Micromonas sp. RCC299
8619923 Dictyostelium discoideum AX4
9688587 Micromonas pusilla CCMP1545
100083863 Ornithorhynchus anatinus
100115514 Nasonia vitripennis
100391519 Callithrix jacchus
100470670 Ailuropoda melanoleuca
1981 Homo sapiens
100009384 Oryctolagus cuniculus
287986 Rattus norvegicus
208643 Mus musculus
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