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anti-Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) Antibodies

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. Additionally we are shipping EIF4A1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EIF4A1 1973 P60842
EIF4A1 13681 P60843
EIF4A1 287436  
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Top anti-EIF4A1 Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-Fixed, Paraffin-Eembedded Human lung carcinoma tissue stained with EIF4A1 Antibody (N-term),which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Left: Western blot analysis of EIF4A1 Antibody (N-term) in K562 cell line lysates (35 µg/lane). EIF4A1 (arrow) was detected using the purified antibody. Right: Western blot analysis of EIF4A1 (arrow) using EIF4A1 Antibody (N-term). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EIF4A1 gene (Lane 2) (Origene Technologies). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-EIF4A1 Pab (ABIN391393) in K562 cell line lysates (35 µg/lane). EIF4A1(arrow) was detected using the purified polyclonal antibody. Western blot analysis of EIF4A1 (arrow) using rabbit polyclonal EIF4A1 Antibody (N-term) (ABIN391393). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the EIF4A1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-EIF4A1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: 721_B cell lysate WB Suggested Anti-EIF4A1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control:.21_B cell lysate  EIF4A1 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB EIF4A1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 3 to 4 Days
$473.93
Details
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF   50 μL Log in to see 8 to 10 Days
$390.50
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$683.83
Details

EIF4A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human ,
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-EIF4A1 Antibodies

  1. Human Polyclonal EIF4A1 Primary Antibody for EIA, IHC (p) - ABIN359486 : Suzuki, Garces, Edmonds, Hiller, Hyberts, Marintchev, Wagner: PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 references for ABIN359486

  2. Human Polyclonal EIF4A1 Primary Antibody for IHC (p), WB - ABIN391393 : Kim, Kim, Jang: Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A. in The EMBO journal 2007 (PubMed)
    Show all 2 references for ABIN391393

More Antibodies against EIF4A1 Interaction Partners

Human Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) interaction partners

  1. Studies indicate a developing focus on targeting eukaryotic initiation factor 4A (show DDX39 Antibodies) eIF4A1 and eIF4A2 (show EIF4A2 Antibodies) as cancer therapy.

  2. Immunohistochemical analysis was performed on over 3000 breast tumors to investigate the relationship among expression of eIF4A1, the helicase-modulating proteins eIF4B (show EIF4B Antibodies), eIF4E (show EIF4E Antibodies) and PDCD4 (show PDCD4 Antibodies), and clinical outcome.

  3. Collectively, these data suggested that a potential role of NS4A in antagonizing host antiviral defense is by recruiting eIF4AI and escaping the translation inhibition mediated by PKR (show PKLR Antibodies).

  4. eIF4A functions as an adenosine triphosphate-dependent processive helicase when complexed with two accessory proteins, eIF4G (show EIF4G1 Antibodies) and eIF4B (show EIF4B Antibodies).

  5. demonstrate that DAP5 associates with eIF2beta and eIF4AI to stimulate IRES-dependent translation of cellular mRNAs

  6. Studies indicate that eukaryotic initiation factor 4AI (EIF4AI) undergoes large conformational transitions, while unwinding RNA hairpins.

  7. Data indicate that caspase (show CASP3 Antibodies) recruitment domain family, member 11 protein CARD11 (show CARD11 Antibodies) has complex 5'UTRs and is sensitive to eIF4A RNA helicase (show DDX46 Antibodies) inhibition.

  8. Increased Expression of EIF4A1 is associated with poor response to Brachytherapy in Cervical Cancer.

  9. report of an eIF4A RNA helicase (show DDX46 Antibodies)-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds

  10. The E186 residue was found to be of significance for RNA-dependent ATPase (show DNAH8 Antibodies) activity for eIF4AI alone and in the presence of eIF4AI-binding domains of eIF4GI (show EIF4G1 Antibodies), binding between eIF4AI and eIF4GI (show EIF4G1 Antibodies) domains were also significantly influenced by mutation of E186.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4A1 (EIF4A1) interaction partners

  1. the central A-rich domains of BC RNAs target eIF4A, specifically inhibiting its RNA helicase activity

  2. analysis of the tandem MA-3 (show PDCD6 Antibodies) region of Pdcd4 (show PDCD4 Antibodies) protein and characterization of its interactions with eIF4A and eIF4G (show EIF4G1 Antibodies)

  3. Pdcd4 (show PDCD4 Antibodies) binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4 (show PDCD4 Antibodies)-eIF4A binding and consequent inhibition of translation are required for Pdcd4 (show PDCD4 Antibodies) transrepression of AP-1 (show JUN Antibodies).

  4. The binding of pateamine to eIF4A presets the protein in the high-affinity RNA-binding state, which stimulates ATP binding, hydrolysis, and RNA unwinding.

  5. interactions between Pdcd4 (show PDCD4 Antibodies) and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G (show EIF4G1 Antibodies)

  6. analysis of cells of eIF4GIf molecules lacking either the PABP (show EBP Antibodies)-binding site, the eIF3 (show EIF3A Antibodies)-binding site, the middle domain eIF4A-binding site, or the C-terminal segment that includes the second eIF4A-binding site

EIF4A1 Antigen Profile

Protein Summary

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).

Gene names and symbols associated with EIF4A1

  • eukaryotic translation initiation factor 4A1 (eif4a1) antibody
  • eukaryotic translation initiation factor 4A1 (EIF4A1) antibody
  • eukaryotic translation initiation factor 4A, isoform 1 (EIF4A1) antibody
  • eukaryotic translation initiation factor 4A1 (Eif4a1) antibody
  • BM-010 antibody
  • Ddx2a antibody
  • EIF-4A antibody
  • eIF-4A-I antibody
  • Eif4 antibody
  • EIF4A antibody
  • eIF4A-I antibody

Protein level used designations for EIF4A1

translation initiation factor eIF4A I , eukaryotic translation initiation factor 4A1 , eukaryotic translation initiation factor 4A, isoform 1 , eukaryotic translation initiation factor 4A , eukaryotic initiation factor 4A-I , eukaryotic translation initiation factor 4A-like , eukaryotic initiation factor 4A-I-like , ATP-dependent RNA helicase eIF4A-1 , eIF-4A-I , eIF4A-I , eukaryotic initiation factor 4AI , initiation factor eIF-4A long form

GENE ID SPECIES
443739 Xenopus laevis
479485 Canis lupus familiaris
496556 Xenopus (Silurana) tropicalis
100061902 Equus caballus
100101929 Sus scrofa
100355889 Oryctolagus cuniculus
100388544 Callithrix jacchus
100582095 Nomascus leucogenys
748995 Pan troglodytes
1973 Homo sapiens
13681 Mus musculus
287436 Rattus norvegicus
695050 Macaca mulatta
100173783 Pongo abelii
100688577 Canis lupus familiaris
504958 Bos taurus
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