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Required for the binding of mRNA to ribosomes. Additionally we are shipping EIF4B Kits (6) and EIF4B Proteins (4) and many more products for this protein.
Showing 10 out of 187 products:
Human Monoclonal EIF4B Primary Antibody for EIA, IF - ABIN1107074
Mokas, Mills, Garreau, Fournier, Robert, Arya, Kaufman, Pelletier, Mazroui: Uncoupling stress granule assembly and translation initiation inhibition. in Molecular biology of the cell 2009
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Human Polyclonal EIF4B Primary Antibody for EIA, IHC (p) - ABIN357289
Milburn, Hershey, Davies, Kelleher, Kaufman: Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. in The EMBO journal 1990
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Human Polyclonal EIF4B Primary Antibody for IHC (p), WB - ABIN401568
Landry, Chrétien, Lambert, Hickey, Weber: Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. in The Journal of cell biology 1989
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Human Polyclonal EIF4B Primary Antibody for IHC (p), WB - ABIN388670
Doepker, Hsu, Saffran, Smiley: Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. in Journal of virology 2004
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Human Monoclonal EIF4B Primary Antibody for ICC, FACS - ABIN969517
Shahbazian, Roux, Mieulet, Cohen, Raught, Taunton, Hershey, Blenis, Pende, Sonenberg: The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. in The EMBO journal 2006
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Cow (Bovine) Polyclonal EIF4B Primary Antibody for IHC, WB - ABIN2778771
Suzuki, Fujisawa, Ando, Niino, Ohsawa, Shimokata, Ohta: Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae. in Neurology 2004
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Human Polyclonal EIF4B Primary Antibody for IHC (p), WB - ABIN401564
Gingras, Raught, Sonenberg: Regulation of translation initiation by FRAP/mTOR. in Genes & development 2001
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Human Polyclonal EIF4B Primary Antibody for IP, WB - ABIN408587
Meijer, Kong, Lu, Wilczynska, Spriggs, Robinson, Godfrey, Willis, Bushell: Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation. in Science (New York, N.Y.) 2013
Data show that two functionally redundant isoforms of Drosophila eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
Results indicate that eIF4B integrates the signals from Pim (show PIM1 Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathways in Abl (show ABL1 Antibodies)-expressing leukemic cells.
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B.
S6K1 (show RPS6KB1 Antibodies) enhances c-Myc (show MYC Antibodies) translation efficiency by modulating the phosphorylation of eukaryotic initiation factor (show EIF4G1 Antibodies) eIF4B, which is critical to unwind its structured 5' untranslated region.
EIF4B, as a potentially key fragile point in EGFR (show EGFR Antibodies) and mTOR (show FRAP1 Antibodies) inhibitor synergy.
eIF4B is the RSK (show RPS6KA1 Antibodies) downstream effector responsible for elevated Lamgamma2 as well as MYC (show MYC Antibodies) protein in neoplastic epithelial cells.
The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus.
eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX (show DAXX Antibodies) and ERCC5 (show ERCC5 Antibodies) are identified as novel prognostic markers for poor survival in DLBCL
Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain.
Overexpression of pim-2 (show PIM2 Antibodies) may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis.
our results identify eIF4B as a critical substrate of Pim (show PIM1 Antibodies) kinases in mediating the activity of Abl (show ABL1 Antibodies) oncogenes
PKR (show EIF2AK2 Antibodies) inhibition reduced the expression of eIF4B and C/EBPbeta (show CEBPB Antibodies) in an eIF2alpha (show EIF2A Antibodies)-independent manner
Maintenance of eIF4E (show EIF4E Antibodies) interaction with eIF4G (show EIF4G1 Antibodies) was not by itself sufficient to sustain global rates of protein synthesis in the absence of mTORC1 signaling to p70S6K1 (show RPS6KB1 Antibodies); phosphorylation of both eIF4B and PDCD4 (show PDCD4 Antibodies) was additionally required.
C-loops bind to eIF4B and prevent the factor's interaction with 18S rRNA of the small ribosomal subunit.
Phosphorylation of eIF4B on Ser422 by p90 (show GPAM Antibodies) ribosomal protein S6 (show RPS6 Antibodies) kinase (show RPS6KB1 Antibodies) (RSK (show RPS6KA1 Antibodies)) and S6K (show RPS6KB1 Antibodies) is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3 (show EIF4E3 Antibodies).
These data provide novel insights into complex multikinase regulation of eIF4B phosphorylation and reveal an important mechanism by which PKB (show AKT2 Antibodies) can regulate translation, potentially critical for the transforming capacity of this AGC (show ACAN Antibodies) kinase family member.
Results establish critical roles for S6K (show RPS6KB1 Antibodies) and RSK (show RPS6KA1 Antibodies) in the induction of IFN-dependent biological effects and define a key regulatory role for eIF4B as a common mediator and integrator of IFN-generated signals from these kinases.
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
eukaryotic initiation factor 4B
, eukaryotic translation initiation factor 4B
, hypothetical protein
, Eukaryotic translation initiation factor 4B