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Required for the binding of mRNA to ribosomes. Additionally we are shipping EIF4B Antibodies (208) and EIF4B Proteins (4) and many more products for this protein.
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Data show that two functionally redundant isoforms of Drosophila eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells.
Results indicate that eIF4B integrates the signals from Pim (show PIM1 ELISA Kits) and PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits)/mTOR (show FRAP1 ELISA Kits) pathways in Abl (show ABL1 ELISA Kits)-expressing leukemic cells.
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B.
S6K1 (show RPS6KB1 ELISA Kits) enhances c-Myc (show MYC ELISA Kits) translation efficiency by modulating the phosphorylation of eukaryotic initiation factor (show EIF4G1 ELISA Kits) eIF4B, which is critical to unwind its structured 5' untranslated region.
EIF4B, as a potentially key fragile point in EGFR (show EGFR ELISA Kits) and mTOR (show FRAP1 ELISA Kits) inhibitor synergy.
eIF4B is the RSK (show RPS6KA1 ELISA Kits) downstream effector responsible for elevated Lamgamma2 as well as MYC (show MYC ELISA Kits) protein in neoplastic epithelial cells.
The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus.
eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX (show DAXX ELISA Kits) and ERCC5 (show ERCC5 ELISA Kits) are identified as novel prognostic markers for poor survival in DLBCL
Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain.
Overexpression of pim-2 (show PIM2 ELISA Kits) may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis.
PKR (show EIF2AK2 ELISA Kits) inhibition reduced the expression of eIF4B and C/EBPbeta (show CEBPB ELISA Kits) in an eIF2alpha (show EIF2A ELISA Kits)-independent manner
Maintenance of eIF4E (show EIF4E ELISA Kits) interaction with eIF4G (show EIF4G1 ELISA Kits) was not by itself sufficient to sustain global rates of protein synthesis in the absence of mTORC1 signaling to p70S6K1 (show RPS6KB1 ELISA Kits); phosphorylation of both eIF4B and PDCD4 (show PDCD4 ELISA Kits) was additionally required.
C-loops bind to eIF4B and prevent the factor's interaction with 18S rRNA of the small ribosomal subunit.
Phosphorylation of eIF4B on Ser422 by p90 (show GPAM ELISA Kits) ribosomal protein S6 (show RPS6 ELISA Kits) kinase (show RPS6KB1 ELISA Kits) (RSK (show RPS6KA1 ELISA Kits)) and S6K (show RPS6KB1 ELISA Kits) is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3 (show EIF4E3 ELISA Kits).
These data provide novel insights into complex multikinase regulation of eIF4B phosphorylation and reveal an important mechanism by which PKB (show AKT2 ELISA Kits) can regulate translation, potentially critical for the transforming capacity of this AGC (show ACAN ELISA Kits) kinase family member.
Results establish critical roles for S6K (show RPS6KB1 ELISA Kits) and RSK (show RPS6KA1 ELISA Kits) in the induction of IFN-dependent biological effects and define a key regulatory role for eIF4B as a common mediator and integrator of IFN-generated signals from these kinases.
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
eukaryotic initiation factor 4B
, eukaryotic translation initiation factor 4B
, hypothetical protein
, Eukaryotic translation initiation factor 4B