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Required for the binding of mRNA to ribosomes. Additionally we are shipping EIF4B Antibodies (208) and EIF4B Kits (6) and many more products for this protein.
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Human EIF4B Protein expressed in Wheat germ - ABIN1352593
Chen, Lin, Chow, Lee: Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells. in Proteomics 2011
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Data show that two functionally redundant isoforms of Drosophila eukaryotic initiation factor 4B are involved in cap-dependent translation, cell survival, and proliferation.
Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells.
Results indicate that eIF4B integrates the signals from Pim (show PIM1 Proteins) and PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) pathways in Abl (show ABL1 Proteins)-expressing leukemic cells.
MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B.
S6K1 (show RPS6KB1 Proteins) enhances c-Myc (show MYC Proteins) translation efficiency by modulating the phosphorylation of eukaryotic initiation factor (show EIF4G1 Proteins) eIF4B, which is critical to unwind its structured 5' untranslated region.
EIF4B, as a potentially key fragile point in EGFR (show EGFR Proteins) and mTOR (show FRAP1 Proteins) inhibitor synergy.
eIF4B is the RSK (show RPS6KA1 Proteins) downstream effector responsible for elevated Lamgamma2 as well as MYC (show MYC Proteins) protein in neoplastic epithelial cells.
The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus.
eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX (show DAXX Proteins) and ERCC5 (show ERCC5 Proteins) are identified as novel prognostic markers for poor survival in DLBCL
Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain.
Overexpression of pim-2 (show PIM2 Proteins) may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis.
PKR (show EIF2AK2 Proteins) inhibition reduced the expression of eIF4B and C/EBPbeta (show CEBPB Proteins) in an eIF2alpha (show EIF2A Proteins)-independent manner
Maintenance of eIF4E (show EIF4E Proteins) interaction with eIF4G (show EIF4G1 Proteins) was not by itself sufficient to sustain global rates of protein synthesis in the absence of mTORC1 signaling to p70S6K1 (show RPS6KB1 Proteins); phosphorylation of both eIF4B and PDCD4 (show PDCD4 Proteins) was additionally required.
C-loops bind to eIF4B and prevent the factor's interaction with 18S rRNA of the small ribosomal subunit.
Phosphorylation of eIF4B on Ser422 by p90 (show GPAM Proteins) ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) (RSK (show RPS6KA1 Proteins)) and S6K (show RPS6KB1 Proteins) is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3 (show EIF4E3 Proteins).
These data provide novel insights into complex multikinase regulation of eIF4B phosphorylation and reveal an important mechanism by which PKB (show AKT2 Proteins) can regulate translation, potentially critical for the transforming capacity of this AGC (show ACAN Proteins) kinase family member.
Results establish critical roles for S6K (show RPS6KB1 Proteins) and RSK (show RPS6KA1 Proteins) in the induction of IFN-dependent biological effects and define a key regulatory role for eIF4B as a common mediator and integrator of IFN-generated signals from these kinases.
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
eukaryotic initiation factor 4B
, eukaryotic translation initiation factor 4B
, hypothetical protein
, Eukaryotic translation initiation factor 4B