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Eukaryotic Translation Initiation Factor 4E Proteins (EIF4E)

The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Antibodies (237) and EIF4E Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EIF4E 1977 P06730
EIF4E 13684 P63073
EIF4E 117045 P63074
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Top EIF4E Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,526.33
Details
Yeast Aplysia californica His tag   1 mg Log in to see 56 to 66 Days
$2,531.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,535.50
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,535.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,535.50
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 6 Days
$285.21
Details

EIF4E Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced EIF4E Proteins

  1. Human EIF4E Protein expressed in Escherichia coli (E. coli) - ABIN667809 : Piron, Nicolaï, Minoïa, Piednoir, Moretti, Salgues, Zamir, Caranta, Bendahmane: An induced mutation in tomato eIF4E leads to immunity to two potyviruses. in PLoS ONE 2010 (PubMed)
    Show all 2 references for ABIN667809

  2. Human EIF4E Protein expressed in Wheat germ - ABIN1352595 : Andrieu, Taieb, Baylot, Ettinger, Soubeyran, De-Thonel, Nelson, Garrido, So, Fazli, Bladou, Gleave, Iovanna, Rocchi: Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E. in Oncogene 2010 (PubMed)

More Proteins for Eukaryotic Translation Initiation Factor 4E (EIF4E) Interaction Partners

Fruit Fly (Drosophila melanogaster) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Phosphorylation of 4E-BP1 impairs the compet (show EIF4EBP1 Proteins)ition with eIF4G for eIF4E binding.

  2. Both eIF4E-1 and eIF4E-3 (show EIF4E3 Proteins) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.

  3. eIF4E-binding protein (show EIF4EBP1 Proteins) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.

  4. Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.

  5. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

  6. eIF4E regulates the sex-specific expression of the master switch gene Sxl.

  7. data are consistent with the idea that Parkin (show PARK2 Proteins) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.

  8. results show that LK6 binds to ERK (show MAPK1 Proteins) and is activated by ERK (show MAPK1 Proteins) signalling and it is responsible for phosphorylating eIF4E in Drosophila

  9. our results suggest that the level of eIF4E protein is regulated by Diap1 (show DIAPH1 Proteins), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.

  10. These results suggest that the eIF4E-1,2 gene is regulated by Hfp through a mechanism linked to transcription control and 3' splice site selection, which determines the pattern and translation efficiency of eIF4E-1,2 mRNAs.

Xenopus laevis Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Pumilio 2 (show PUM2 Proteins) controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.

  2. CDK1 (show CDK1 Proteins) and calcineurin (show PPP3CA Proteins) regulate Maskin (show TACC3 Proteins) association with eIF4E and translational control of cell cycle progression

  3. CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T (show EIF4ENIF1 Proteins) and eIF4E1b (show EIF4E1B Proteins)

Human Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. This study demonstrates that the activation of eIF4E gene is an essential component of the malignant phenotype in ovarian cancer

  2. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer

  3. mechanistic analysis suggested that LMP1 (show PDLIM7 Proteins) overexpression induced the expression of eIF4E, while eIF4E-shRNA dramatically attenuated the increase in cell proliferation, invasion, migration and the inhibition of apoptosis triggered by LMP-1 (show PDLIM7 Proteins) upregulation

  4. Our findings identify the eIF4E- beta-catenin (show CTNNB1 Proteins) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  5. Activated eIF4E, which is phosphorylated by MNK1 (show MKNK1 Proteins), is a regulator of Sox2 (show SOX2 Proteins) expression after irradiation of pancreatic tumor cells.

  6. Findings provide new evidence that PRMT5 (show PRMT5 Proteins) plays an important role in CRC (show CALR Proteins) pathogenesis through epigenetically regulating arginine methylation of oncogenes such as eIF4E and FGFR3 (show FGFR3 Proteins).

  7. Data suggest MNK1 (show MKNK1 Proteins)/MNK2 (show MKNK2 Proteins) stimulate mRNA translation but only of mRNA containing both 5-prime-terminal cap and hairpin duplex; this stimulation involves up-regulation of phosphorylation/mRNA un-winding activity of eIF4E (via decreased binding to eIF4G (show EIF4G1 Proteins)).

  8. Molecular structure of EIF4E bound to 4E-BP1 (show EIF4EBP1 Proteins) provides insight into the consequences of phosphorylation.Phosphorylation of 4E-BP1 (show EIF4EBP1 Proteins) impairs the competition with eIF4G (show EIF4G1 Proteins) for eIF4E binding.

  9. Results suggest that the phosphorylated serine 209 residue of eukaryotic translation initiation factor 4E (p-eIF4E) might be a potential target for developing small molecule-based new therapies for leukemia.

  10. Report the presence of a cryptic pocket at the protein-binding interface of eIF4E, which opens transiently during molecular dynamics simulations of the protein in solvent water and is observed to be stable when water is mixed with benzene molecules.

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. Results of our study suggest that the eIF4E/Fmr1 (show FMR1 Proteins) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.

  2. Our findings identify the eIF4E- beta-catenin (show CTNNB1 Proteins) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.

  3. Unphosphorylated HSP27 (show HSPB1 Proteins) associates with eIF4E in osteoblasts and suppresses the translation initiation process.

  4. Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 Proteins)-mediated S6K1 (show RPS6KB1 Proteins) and 4E-BP1 (show EIF4EBP1 Proteins)/eIF4E pathways, resulting in caspase (show CASP3 Proteins)-dependent and -independent apoptosis in neuronal cells.

  5. Findings indicate eIF4E is maintained at levels in excess (show RCC1 Proteins) for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.

  6. a light- and circadian clock-regulated MAPK (show MAPK1 Proteins)/MNK (show ATP7A Proteins) pathway led to phosphorylation of the cap-binding protein eIF4E

  7. mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.

  8. Data suggest that MAP kinase (show MAPK1 Proteins)-interacting kinases (Mnk1 (show MKNK1 Proteins), Mnk2 (show MKNK2 Proteins)) regulate cell migration/wound healing, expression of vimentin (show VIM Proteins), stability of vimentin (show VIM Proteins) protein, and binding of eIF4E and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (show CYFIP1 Proteins)).

  9. results show that the activation of p38 (show CRK Proteins) and Mnk (show ATP7A Proteins) during MNV1 infection is important for MNV1 replication. Furthermore, phosphorylated eIF4E relocates to the polysomes, and this contributes to changes in

  10. Maintaining eIF4E levels below its proneoplastic threshold is an important anticancer defense in normal cells, with important implications for understanding pregnancy-associated breast cancer.

Pig (Porcine) Eukaryotic Translation Initiation Factor 4E (EIF4E) interaction partners

  1. These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (show EIF4A2 Proteins) complex through a direct eIF4E interaction

  2. it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (show EIF4A2 Proteins) and degradation of 4E-BP1 (show EIF4EBP1 Proteins) and/or truncation of 4E-BP2 (show EIF4EBP2 Proteins) that together ensures correct translational control during the dynamic process of conceptus implantation

  3. Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.

  4. The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 Proteins) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 Proteins) binding dynamic depending on the type of implantation.

  5. Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.

  6. Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.

EIF4E Protein Profile

Protein Summary

The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with EIF4E

  • Eukaryotic initiation factor 4E (eIF-4E)
  • eucaryotic initiation factor6 (eif6)
  • eukaryotic translation initiation factor 4E (eif4e)
  • eIF-4E protein (eif4e)
  • eukaryotic translation initiation factor 4E (EIF4E)
  • eukaryotic translation initiation factor 4E (Eif4e)
  • eukaryotic translation initiation factor 4ea (eif4ea)
  • translation initiation factor eIF4E (LOC100533326)
  • 2 protein
  • 0260/09 protein
  • 0587/11 protein
  • 0589/11 protein
  • 0919/12 protein
  • 1004/13 protein
  • 7238 protein
  • AUTS19 protein
  • cbp protein
  • CG4035 protein
  • CT13384 protein
  • CT39424 protein
  • CT39426 protein
  • D-eIF4E protein
  • deIF-4E protein
  • deIF4E protein
  • Dmel\\CG4035 protein
  • EG668879 protein
  • EIF-4E protein
  • eIF-4E1 protein
  • eIF-4E2 protein
  • eIF-4EII protein
  • eif4e protein
  • eIF 4E protein
  • eif4e-1 protein
  • eIF4E-1/2 protein
  • eIF4E-2 protein
  • Eif4e-ps protein
  • EIF4E1 protein
  • eIF4EI protein
  • EIF4EL1 protein
  • EIF4F protein
  • If4e protein
  • l(3)07238 protein
  • l(3)67Af protein
  • l(3)S025007 protein
  • l(3)S026009 protein
  • l(3)S058711 protein
  • l(3)S091912 protein
  • zgc:86680 protein

Protein level used designations for EIF4E

CG4035-PA , CG4035-PB , CG4035-PC , CG4035-PD , CG4035-PE , CG4035-PF , CG4035-PG , CG4035-PH , CG4035-PI , cap binding protein , eIF-4E-PA , eIF-4E-PB , eIF-4E-PC , eIF-4E-PD , eIF-4E-PE , eIF-4E-PF , eIF-4E-PG , eIF-4E-PH , eIF-4E-PI , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , lethal(3)67Af , eucaryotic initiation factor6 , eIF4E , PCO081734 , PCO081734_ov , mRNA cap-binding protein , eukaryotic translation initiation factor small subunit , eIF-4F 25 kDa subunit , eIF-4E , eukaryotic translation initiation factor 4E-like 1 , elongation initiation factor 4E , eukaryotic translation initiation factor 4e 1a , eukaryotic translation initiation factor eIF4E-1

GENE ID SPECIES
45525 Drosophila melanogaster
542608 Zea mays
548663 Xenopus (Silurana) tropicalis
399255 Xenopus laevis
1977 Homo sapiens
13684 Mus musculus
117045 Rattus norvegicus
422703 Gallus gallus
734259 Xenopus laevis
281751 Bos taurus
100009338 Oryctolagus cuniculus
487870 Canis lupus familiaris
100038030 Sus scrofa
79380 Danio rerio
100533326 Aplysia californica
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