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The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Proteins (18) and EIF4E Kits (6) and many more products for this protein.
Showing 10 out of 259 products:
Chicken Monoclonal EIF4E Primary Antibody for BI, WB - ABIN967869
De Benedetti, Rhoads: Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. in Proceedings of the National Academy of Sciences of the United States of America 1990
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Chicken Monoclonal EIF4E Primary Antibody for BI, WB - ABIN967870
Jiang, Ballou, Lin: Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver. in The Journal of biological chemistry 2001
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Human Monoclonal EIF4E Primary Antibody for FACS, WB - ABIN659031
Hoeffer, Cowansage, Arnold, Banko, Moerke, Rodriguez, Schmidt, Klosi, Chorev, Lloyd, Pierre, Wagner, LeDoux, Klann: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. in Proceedings of the National Academy of Sciences of the United States of America 2011
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Human Monoclonal EIF4E Primary Antibody for ICC, FACS - ABIN969094
Slepenkov, Korneeva, Rhoads: Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex. in The Journal of biological chemistry 2008
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Human Monoclonal EIF4E Primary Antibody for IF, WB - ABIN659032
Hoeffer, Santini, Ma, Arnold, Whelan, Wong, Pierre, Pelletier, Klann: Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. in Journal of neurophysiology 2013
Human Polyclonal EIF4E Primary Antibody for ICC, IF - ABIN4307638
Chen, Zhu, McCauley, Zhao, Johnson, Rhoads, El-Kadi: Diminished satellite cell fusion and S6K1 expression in myotubes derived from skeletal muscle of low birth weight neonatal pigs. in Physiological reports 2017
Human Monoclonal EIF4E Primary Antibody for FACS, IF - ABIN966052
Holm, Byrnes, Johnson, Abreo, Sehon, Alley, Meschonat, Md, Li: A prospective trial on initiation factor 4E (eIF4E) overexpression and cancer recurrence in node-negative breast cancer. in Annals of surgical oncology 2008
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The structures of eIF4E-eIF4G (show EIF4G1 Antibodies) complexes reveal an extended interface to regulate translation initiation.
Phosphorylation of 4E-BP1 (show EIF4EBP1 Antibodies) impairs the competition with eIF4G (show EIF4G1 Antibodies) for eIF4E binding.
Both eIF4E-1 and eIF4E-3 (show EIF4E3 Antibodies) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.
eIF4E-binding protein (show EIF4EBP1 Antibodies) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
eIF4E regulates the sex-specific expression of the master switch gene Sxl.
data are consistent with the idea that Parkin (show PARK2 Antibodies) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.
results show that LK6 binds to ERK (show MAPK1 Antibodies) and is activated by ERK (show MAPK1 Antibodies) signalling and it is responsible for phosphorylating eIF4E in Drosophila
our results suggest that the level of eIF4E protein is regulated by Diap1 (show DIAPH1 Antibodies), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.
Pumilio 2 (show PUM2 Antibodies) controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.
CDK1 (show CDK1 Antibodies) and calcineurin regulate Maskin (show TACC3 Antibodies) association with eIF4E and translational control of cell cycle progression
CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T (show EIF4ENIF1 Antibodies) and eIF4E1b (show EIF4E1B Antibodies)
Study identified and established the presence of an evolutionarily conserved water-bridge structural module which is an integral component of the recognition of the 5' mRNA cap by eIF4E during the process of translation initiation.
Here, the authors identify the domains responsible for the eIF4E/human rhinovirus 2 2A(pro) interaction using molecular modelling and describe mutations that impair this interaction and delay in vitro cleavage of eIF4G (show EIF4G1 Antibodies) isoforms.
Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation.
There were significantly higher expressions of p-eIF4E and p-4EBP-1 (show EIF4EBP1 Antibodies) proteins in the cases with lymph node metastasis than in those without lymph node metastasis.
Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway.
Human endogenous eIF4E1 and eIF4E2 (show EIF4E2 Antibodies) behave under stresses similarly as their GFP-tagged counterparts.
High EIF4E expression is associated with malignant peripheral nerve sheath tumors and vestibular schwannomas.
4E-BP1 (show EIF4EBP1 Antibodies) has tumor suppressor activity by inhibiting eIF4E and, thus, blocking mRNA translation and proliferation. This is corroborated by elevated levels of phosphorylated and hence inactive 4E-BP1 (show EIF4EBP1 Antibodies), which are detected in various cancers
The studies suggest that MNK (show ATP7A Antibodies)-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1 (show CYFIP1 Antibodies). (Review)
Our work demonstrates that a single phosphorylation site on the 5' cap-binding protein eIF4E is a critical mechanism for changes in nociceptor excitability that drive the development of chronic pain.
data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Antibodies)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.
Results of our study suggest that the eIF4E/Fmr1 (show FMR1 Antibodies) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.
Our findings identify the eIF4E- beta-catenin (show CTNNB1 Antibodies) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.
Unphosphorylated HSP27 (show HSPB1 Antibodies) associates with eIF4E in osteoblasts and suppresses the translation initiation process.
Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 Antibodies)-mediated S6K1 (show RPS6KB1 Antibodies) and 4E-BP1 (show EIF4EBP1 Antibodies)/eIF4E pathways, resulting in caspase (show CASP3 Antibodies)-dependent and -independent apoptosis in neuronal cells.
Findings indicate eIF4E is maintained at levels in excess (show RCC1 Antibodies) for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.
a light- and circadian clock-regulated MAPK (show MAPK1 Antibodies)/MNK (show ATP7A Antibodies) pathway led to phosphorylation of the cap-binding protein eIF4E
mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.
Data suggest that MAP kinase (show MAPK1 Antibodies)-interacting kinases (Mnk1 (show MKNK1 Antibodies), Mnk2 (show MKNK2 Antibodies)) regulate cell migration/wound healing, expression of vimentin (show VIM Antibodies), stability of vimentin (show VIM Antibodies) protein, and binding of eIF4E and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (show CYFIP1 Antibodies)).
These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (show EIF4A2 Antibodies) complex through a direct eIF4E interaction
it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (show EIF4A2 Antibodies) and degradation of 4E-BP1 (show EIF4EBP1 Antibodies) and/or truncation of 4E-BP2 (show EIF4EBP2 Antibodies) that together ensures correct translational control during the dynamic process of conceptus implantation
Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.
The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 Antibodies) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 Antibodies) binding dynamic depending on the type of implantation.
Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.
Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.
, cap binding protein
, eukaryotic initiation factor 4E
, eukaryotic translation initiation factor 4E
, eucaryotic initiation factor6
, mRNA cap-binding protein
, eukaryotic translation initiation factor small subunit
, eIF-4F 25 kDa subunit
, eukaryotic translation initiation factor 4E-like 1
, elongation initiation factor 4E
, eukaryotic translation initiation factor 4e 1a
, eukaryotic translation initiation factor eIF4E-1