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The protein encoded by EIF4E is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. Additionally we are shipping EIF4E Proteins (18) and EIF4E Kits (5) and many more products for this protein.
Showing 10 out of 250 products:
Chicken Monoclonal EIF4E Primary Antibody for BI, WB - ABIN967869
De Benedetti, Rhoads: Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. in Proceedings of the National Academy of Sciences of the United States of America 1990
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Human Polyclonal EIF4E Primary Antibody for DB - ABIN389859
Rychlik, Russ, Rhoads: Phosphorylation site of eukaryotic initiation factor 4E. in The Journal of biological chemistry 1987
Show all 4 references for ABIN389859
Human Polyclonal EIF4E Primary Antibody for EIA - ABIN358406
Whalen, Gingras, Amankwa, Mader, Branton, Aebersold, Sonenberg: Phosphorylation of eIF-4E on serine 209 by protein kinase C is inhibited by the translational repressors, 4E-binding proteins. in The Journal of biological chemistry 1996
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Human Polyclonal EIF4E Primary Antibody for EIA, IHC (p) - ABIN357297
Dorfman, Lazaris-Karatzas, Malo, Sonenberg, Gros: Chromosomal assignment of one of the mammalian translation initiation factor eIF-4E genes. in Genomics 1991
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Human Polyclonal EIF4E Primary Antibody for IHC (p), WB - ABIN388675
Pelletier, Brook, Housman: Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. in Genomics 1991
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Human Monoclonal EIF4E Primary Antibody for FACS, WB - ABIN659031
Hoeffer, Cowansage, Arnold, Banko, Moerke, Rodriguez, Schmidt, Klosi, Chorev, Lloyd, Pierre, Wagner, LeDoux, Klann: Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. in Proceedings of the National Academy of Sciences of the United States of America 2011
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Cow (Bovine) Polyclonal EIF4E Primary Antibody for IHC, WB - ABIN2778784
Lee, Cho, Kim: Ectopic expression of eIF4E-transporter triggers the movement of eIF4E into P-bodies, inhibiting steady-state translation but not the pioneer round of translation. in Biochemical and biophysical research communications 2008
Human Monoclonal EIF4E Primary Antibody for IF, WB - ABIN659032
Hoeffer, Santini, Ma, Arnold, Whelan, Wong, Pierre, Pelletier, Klann: Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. in Journal of neurophysiology 2013
Human Polyclonal EIF4E Primary Antibody for FACS, IHC (p) - ABIN650675
Kim, Wang, Ryu: Incorporation of eukaryotic translation initiation factor eIF4E into viral nucleocapsids via interaction with hepatitis B virus polymerase. in Journal of virology 2009
Phosphorylation of 4E-BP1 (show EIF4EBP1 Antibodies) impairs the competition with eIF4G (show EIF4G1 Antibodies) for eIF4E binding.
Both eIF4E-1 and eIF4E-3 (show EIF4E3 Antibodies) are required in spermatocytes for chromosome condensation and cytokinesis during the meiotic stages.
eIF4E-binding protein (show EIF4EBP1 Antibodies) requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
Protein-protein interactions rather than interactions with the mRNA are essential for the recruitment of eIF4E and for a putative nucleation function.
Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.
eIF4E regulates the sex-specific expression of the master switch gene Sxl.
data are consistent with the idea that Parkin (show PARK2 Antibodies) and eIF4E act in a common pathway, likely modulating cap-dependent translation initiation events.
results show that LK6 binds to ERK (show MAPK1 Antibodies) and is activated by ERK (show MAPK1 Antibodies) signalling and it is responsible for phosphorylating eIF4E in Drosophila
our results suggest that the level of eIF4E protein is regulated by Diap1 (show DIAPH1 Antibodies), and that IAPs may play a role in cap-dependent translation by regulating the level of eIF4E protein.
These results suggest that the eIF4E-1,2 gene is regulated by Hfp through a mechanism linked to transcription control and 3' splice site selection, which determines the pattern and translation efficiency of eIF4E-1,2 mRNAs.
Pumilio 2 (show PUM2 Antibodies) controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.
CDK1 (show CDK1 Antibodies) and calcineurin (show PPP3CA Antibodies) regulate Maskin (show TACC3 Antibodies) association with eIF4E and translational control of cell cycle progression
CPEB, partnered with several highly conserved RNA-binding partners, inhibits protein synthesis in oocytes using a novel pairing of 4E-T (show EIF4ENIF1 Antibodies) and eIF4E1b (show EIF4E1B Antibodies)
Data show that targeting translation initiation (TI) factors eIF4E/eIF4GI (show EIF4G1 Antibodies) reduces migration and epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)), both essential for metastasis, thereby underscoring the potential of TI targeting in non-small cell lung cancer (NSCLC) therapy.
p4E-BP1 (show DLX4 Antibodies) may identify male breast cancers potentially suitable for therapies directed at the upstream kinase, mTOR (show FRAP1 Antibodies)
eIF4E and mTOR (show FRAP1 Antibodies) depletion significantly enhances the anti-proliferative and pro-apoptotic effects of paclitaxel, demonstrating the critical role of eIF4E in oral tongue squamous cell carcinoma cell response to paclitaxel
data suggest a physiological role for MNK1a-Ser (show SIGLEC1 Antibodies)(353) phosphorylation in regulation of the MNK1a kinase, which correlates with increased eIF4E phosphorylation in vitro and in vivo.
eIF4E may play an important role in the development and metastasis of hypopharyngeal carcinoma; its expression may be helpful in establishing the diagnosis, stage and prognosis of this tumour type.
First study showing the induction of miR (show MLXIP Antibodies)-141/EIF4E expression in an acquired model of docetaxel chemoresistant patients with non-small cell lung cancer.
miR503 may increase sensitivity to therapies at least partially through targeting EIF4E suppression of Hepatocellular carcinoma proliferation.
suggests that selective inhibition of translation of YB-1 (show YBX1 Antibodies) mRNA, and probably some other mRNAs as well, by mTOR (show FRAP1 Antibodies) kinase inhibitors is not mediated by the action of the 4E-binding protein upon functions of the 4F-group translation initiation factors
eIF4E protein might result in the malignant progression of hepatocellular carcinoma, and its overexpression may be a powerful prognostic biomarker.
HSP27 (show HSPB1 Antibodies) was found to be regulator of translation initiation and STAT3 (show STAT3 Antibodies) level. Therefore, it suggests that HSP27 (show HSPB1 Antibodies) is a key protein during placental development and trophoblast cell differentiation.
Results of our study suggest that the eIF4E/Fmr1 (show FMR1 Antibodies) double mutant mouse may be a reliable model to study cognitive dysfunction in the context of autism spectrum disorder.
Our findings identify the eIF4E- beta-catenin (show CTNNB1 Antibodies) axis as a critical regulator of lung cancer cell growth and survival, and suggest that its pharmacological inhibition may be therapeutically useful in lung cancer.
Unphosphorylated HSP27 (show HSPB1 Antibodies) associates with eIF4E in osteoblasts and suppresses the translation initiation process.
Rotenone induction of hydrogen peroxide inhibits mTOR (show FRAP1 Antibodies)-mediated S6K1 (show RPS6KB1 Antibodies) and 4E-BP1 (show EIF4EBP1 Antibodies)/eIF4E pathways, resulting in caspase (show CASP3 Antibodies)-dependent and -independent apoptosis in neuronal cells.
Findings indicate eIF4E is maintained at levels in excess (show RCC1 Antibodies) for normal development that are hijacked by cancer cells to drive a translational program supporting tumorigenesis.
a light- and circadian clock-regulated MAPK (show MAPK1 Antibodies)/MNK (show ATP7A Antibodies) pathway led to phosphorylation of the cap-binding protein eIF4E
mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated are resistant to lung metastases in a mammary tumor model, and cells isolated from these mice exhibit impaired invasion.
Data suggest that MAP kinase (show MAPK1 Antibodies)-interacting kinases (Mnk1 (show MKNK1 Antibodies), Mnk2 (show MKNK2 Antibodies)) regulate cell migration/wound healing, expression of vimentin (show VIM Antibodies), stability of vimentin (show VIM Antibodies) protein, and binding of eIF4E and Cyfip1 (cytoplasmic FMR1 interacting protein 1 (show CYFIP1 Antibodies)).
results show that the activation of p38 (show CRK Antibodies) and Mnk (show ATP7A Antibodies) during MNV1 infection is important for MNV1 replication. Furthermore, phosphorylated eIF4E relocates to the polysomes, and this contributes to changes in
These data suggest that sapovirus VPg can hijack the cellular translation initiation mechanism by recruiting the eIF4F (show EIF4A2 Antibodies) complex through a direct eIF4E interaction
it is proposed that a balanced regulation of the truncation of the cap-binding complex component eIF4F (show EIF4A2 Antibodies) and degradation of 4E-BP1 (show EIF4EBP1 Antibodies) and/or truncation of 4E-BP2 (show EIF4EBP2 Antibodies) that together ensures correct translational control during the dynamic process of conceptus implantation
Results show that in pigs, the truncated eIF4E is located in the endometrial luminal epithelium during implantation. Neither glandulary tissue nor stroma expressed any truncated eIF4E.
The translation initiation in the endometrium is differently regulated by the two eIF4E forms with regard to different 4E-BP1 (show EIF4EBP1 Antibodies) abundance and phosphorylation as well as different eIF4E/4E-BP1 (show EIF4EBP1 Antibodies) binding dynamic depending on the type of implantation.
Modified translational initiation of eIF4E may particularly regulate protein synthesis during conceptus attachment at the time of implantation in swine.
Translation initiation factor eIF4E is phosphorylated during in vitro maturation of pig oocytes with a maximum in metaphase II stage oocytes.
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene.
, cap binding protein
, eukaryotic initiation factor 4E
, eukaryotic translation initiation factor 4E
, eucaryotic initiation factor6
, mRNA cap-binding protein
, eukaryotic translation initiation factor small subunit
, eIF-4F 25 kDa subunit
, eukaryotic translation initiation factor 4E-like 1
, elongation initiation factor 4E
, eukaryotic translation initiation factor 4e 1a
, eukaryotic translation initiation factor eIF4E-1