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Eukaryotic Translation Initiation Factor 4E Binding Protein 2 Proteins (EIF4EBP2)

EIF4EBP2 encodes a member of the eukaryotic translation initiation factor 4E binding protein family. Additionally we are shipping eIF4EBP2 Antibodies (90) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat EIF4EBP2 EIF4EBP2 361845  
EIF4EBP2 1979 Q13542
EIF4EBP2 13688 P70445
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Top eIF4EBP2 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

EIF4EBP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Top referenced eIF4EBP2 Proteins

  1. Human eIF4EBP2 Protein expressed in Escherichia coli (E. coli) - ABIN667385 : Pause, Belsham, Gingras, Donzé, Lin, Lawrence, Sonenberg: Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. in Nature 1994 (PubMed)

More Proteins for Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) Interaction Partners

Human Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) interaction partners

  1. mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E (show EIF4E Proteins))-binding proteins (4E-BPs).

  2. Data show that the eIF4E (show EIF4E Proteins) binding preference for 4E-BP2 over 4E-BP1 (show EIF4EBP1 Proteins) is based on stacking of Arg63 side chain on Trp73 indole ring of eIF4E (show EIF4E Proteins) and construction of hydrophobic space around the Trp73 indole ring by the Leu59-Leu60 sequence of 4E-BP2.

  3. isoaspartate formation repair modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain

  4. 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.

  5. Data show that H2O2 increased eIF4E (show EIF4E Proteins) and 4E-BP1 (show EIF4EBP1 Proteins) expression and eIF4E (show EIF4E Proteins) phosphorylation, and shifted distribution of 4E-BP1 (show EIF4EBP1 Proteins) phosphorylation. These oxidant-mediated alterations occur in concert with changes in factors known to regulate translation kinetics.

  6. PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin (show INS Proteins)

  7. The C-terminal His74-Glu89 region of 4EBP2 acts as an auxiliary function for the major binding of Y(X)4L -binding motif (Tyr54-Leu60) to eIF4E (show EIF4E Proteins).

  8. 4E-BPs regulate the stress granule localization of eIF4E (show EIF4E Proteins)

Mouse (Murine) Eukaryotic Translation Initiation Factor 4E Binding Protein 2 (EIF4EBP2) interaction partners

  1. Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.

  2. Disruption of genes encoding Eif4ebp1 (show EIF4EBP1 Proteins) and Eif4ebp2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.

  3. 4E-BP1 (show EIF4EBP1 Proteins)/2-null cells express less ATGL (show PNPLA2 Proteins) and accumulate more fat than control cells, while knock down of Egr1 (show EGR1 Proteins) in 4E-BP1 (show EIF4EBP1 Proteins)/2-null cells increases ATGL (show PNPLA2 Proteins) expression and decreases fat storage.

  4. translational control through 4E-BP2 represents a unique mechanism for selective regulation of AMPAR synthesis, synaptic function, and long-term plasticity, important for hippocampal-dependent memory processes.

  5. in the absence of 4E-BP proteins, mTORC1-mediated phosphorylation of p70S6K1 (show RPS6KB1 Proteins) is elevated by a reduction in competition between the two substrates for interaction with raptor (show RPTOR Proteins)

  6. isoaspartate formation repair modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain

  7. Two deamidation sites were mapped to an asparagine-rich sequence unique to 4E-BP2. Deamidated 4E-BP2 exhibits increased binding to the mammalian target of rapamycin (mTOR (show FRAP1 Proteins))-binding protein raptor (show RPTOR Proteins).

  8. These results, together with the fact that 4E-BPs are markedly induced during granulo-monocytic differentiation of myeloid cells in vitro, highlight the pivotal role of 4E-BP1 (show EIF4EBP1 Proteins) and 4E-BP2 in the early phases of myelopoiesis

  9. 4E-BP2 plays a crucial role in proper regulation of the eIF4F (show EIF4A2 Proteins) complex during long-term potentiation and learning and memory in the mouse hippocampus.

  10. The 4E-BP2 knockout mice demonstrated altered activity in the rotating rod test, light/dark exploration test, spontaneous alternation T-maze and conditioned taste aversion test.

eIF4EBP2 (EIF4EBP2) Protein Profile

Protein Summary

This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.

Gene names and symbols associated with EIF4EBP2

  • eukaryotic translation initiation factor 4E binding protein 2 (eif4ebp2)
  • eukaryotic translation initiation factor 4E binding protein 2 (Eif4ebp2)
  • eukaryotic translation initiation factor 4E binding protein 2 (EIF4EBP2)
  • eukaryotic initiation factor 4E (TcasGA2_TC012945)
  • eukaryotic translation initiation factor 4E (Tb927.6.1870)
  • eukaryotic translation initiation factor 4E (LmjF30.0450)
  • eukaryotic translation initiation factor 4E binding protein 2 (LOC100342908)
  • 4E-BP2 protein
  • 4EBP2 protein
  • 2810011I19Rik protein
  • AA792569 protein
  • BC010348 protein
  • eIF-4E protein
  • EIF4EBP2 protein
  • MGC75579 protein
  • MGC78987 protein
  • PHAS-II protein
  • PHASII protein
  • Tb06.28P18.1010 protein
  • wu:fa55e11 protein
  • wu:fp45e09 protein

Protein level used designations for EIF4EBP2

eukaryotic translation initiation factor 4E binding protein 2 , eukaryotic translation initiation factor 4E-binding protein 2 , fa55e11 , eukaryotic initiation factor 4E , eukaryotic translation initiation factor 4E , 4E-BP2 , eIF4E-binding protein 2 , phosphorylated, heat and acid stable regulated by insulin protein II , phosphorylated heat- and acid-stable protein regulated by insulin 2

GENE ID SPECIES
394958 Xenopus (Silurana) tropicalis
361845 Rattus norvegicus
386945 Danio rerio
414476 Xenopus laevis
489027 Canis lupus familiaris
658700 Tribolium castaneum
769479 Gallus gallus
782397 Bos taurus
3657825 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5653570 Leishmania major strain Friedlin
100342908 Oryctolagus cuniculus
1979 Homo sapiens
13688 Mus musculus
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