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EIF4EBP2 encodes a member of the eukaryotic translation initiation factor 4E binding protein family. Additionally we are shipping eIF4EBP2 Antibodies (90) and eIF4EBP2 Proteins (13) and many more products for this protein.
Results suggest that IGF2BP3 promotes eIF4E-mediated translational activation through the reduction of EIF4E-BP2 via mRNA degradation, leading to enhanced cell proliferation.
molecular dynamics simulations to investigate both the folded and unfolded states of 4E-BP2 under different phosphorylation states of T37 and T46
mTORC1 controls mitochondrial activity and biogenesis by selectively promoting translation of nucleus-encoded mitochondria-related mRNAs via inhibition of the eukaryotic translation initiation factor 4E (eIF4E (show EIF4E ELISA Kits))-binding proteins (4E-BPs).
Data show that the eIF4E (show EIF4E ELISA Kits) binding preference for 4E-BP2 over 4E-BP1 (show EIF4EBP1 ELISA Kits) is based on stacking of Arg63 side chain on Trp73 indole ring of eIF4E (show EIF4E ELISA Kits) and construction of hydrophobic space around the Trp73 indole ring by the Leu59-Leu60 sequence of 4E-BP2.
isoaspartate formation repair modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain
4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.
Data show that H2O2 increased eIF4E (show EIF4E ELISA Kits) and 4E-BP1 (show EIF4EBP1 ELISA Kits) expression and eIF4E (show EIF4E ELISA Kits) phosphorylation, and shifted distribution of 4E-BP1 (show EIF4EBP1 ELISA Kits) phosphorylation. These oxidant-mediated alterations occur in concert with changes in factors known to regulate translation kinetics.
PHAS-II, but not PHAS-III, contributes to the control of protein synthesis by insulin (show INS ELISA Kits)
The C-terminal His74-Glu89 region of 4EBP2 acts as an auxiliary function for the major binding of Y(X)4L -binding motif (Tyr54-Leu60) to eIF4E (show EIF4E ELISA Kits).
4E-BPs regulate the stress granule localization of eIF4E (show EIF4E ELISA Kits)
data identify SH2B1 (show SH2B1 ELISA Kits) as a major regulator of IRS2 (show IRS2 ELISA Kits) stability, demonstrate a novel feedback mechanism linking mTORC1 signaling with IRS2 (show IRS2 ELISA Kits), and identify 4E-BP2 as a major regulator of proliferation and survival of beta-cells.
Data show that deletion of eukaryotic translation initiation factor 4E-binding protein 1/2 (4E-BP1/2) in erythroid cells rendered them resistant to mammalian target of rapamycin complex 1 (TORC1) inhibition and restored hemoglobin production.
Disruption of genes encoding Eif4ebp1 (show EIF4EBP1 ELISA Kits) and Eif4ebp2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice.
4E-BP1 (show EIF4EBP1 ELISA Kits)/2-null cells express less ATGL (show PNPLA2 ELISA Kits) and accumulate more fat than control cells, while knock down of Egr1 (show EGR1 ELISA Kits) in 4E-BP1 (show EIF4EBP1 ELISA Kits)/2-null cells increases ATGL (show PNPLA2 ELISA Kits) expression and decreases fat storage.
translational control through 4E-BP2 represents a unique mechanism for selective regulation of AMPAR synthesis, synaptic function, and long-term plasticity, important for hippocampal-dependent memory processes.
in the absence of 4E-BP proteins, mTORC1-mediated phosphorylation of p70S6K1 (show RPS6KB1 ELISA Kits) is elevated by a reduction in competition between the two substrates for interaction with raptor (show RPTOR ELISA Kits)
Two deamidation sites were mapped to an asparagine-rich sequence unique to 4E-BP2. Deamidated 4E-BP2 exhibits increased binding to the mammalian target of rapamycin (mTOR (show FRAP1 ELISA Kits))-binding protein raptor (show RPTOR ELISA Kits).
These results, together with the fact that 4E-BPs are markedly induced during granulo-monocytic differentiation of myeloid cells in vitro, highlight the pivotal role of 4E-BP1 (show EIF4EBP1 ELISA Kits) and 4E-BP2 in the early phases of myelopoiesis
4E-BP2 plays a crucial role in proper regulation of the eIF4F (show EIF4A2 ELISA Kits) complex during long-term potentiation and learning and memory in the mouse hippocampus.
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.
eukaryotic translation initiation factor 4E binding protein 2
, eukaryotic translation initiation factor 4E-binding protein 2
, eukaryotic initiation factor 4E
, eukaryotic translation initiation factor 4E
, eIF4E-binding protein 2
, phosphorylated, heat and acid stable regulated by insulin protein II
, phosphorylated heat- and acid-stable protein regulated by insulin 2