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The protein encoded by EIF4ENIF1 is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. Additionally we are shipping EIF4ENIF1 Antibodies (86) and many more products for this protein.
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our data support a model where 4E-T promotes mRNA turnover by physically linking the 3'-terminal mRNA decay machinery to the 5' cap
neural precursors are transcriptionally primed to generate neurons, but an eIF4E (show EIF4E Proteins)/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis.
that while both eIF4E1 (show EIF4E Proteins) and eIF4E2 (show EIF4E2 Proteins) bind 4E-T via the canonical YX 4Lvarphi sequence, nearby downstream sequences also influence eIF4E (show EIF4E Proteins):4E-T interactions
This work has demonstrated the conserved yet unpredicted and surprising translational control of bound mRNAs by 4E-T, which does not involve eIF4E (show EIF4E Proteins), nor P-body components.
Data demonstrate that EIF4ENIF1 is associated with dominantly inherited primary ovarian insufficiency.
The c-Jun N-terminal kinase (JNK) is targeted to processing bodies in response to oxidative stress and promotes the phosphorylation of 4E-T.
human P bodies contain the cap-binding protein eIF4E (show EIF4E Proteins) and the related factor eIF4E-transporter (eIF4E (show EIF4E Proteins)-T), suggesting novel roles for these proteins in targeting mRNAs for 5' --> 3' degradation
A role for the eIF4E-binding protein (show NGDN Proteins) 4E-T in P-body formation and mRNA decay is described.
Overexpression of eIF4E (show EIF4E Proteins)-T triggers the movement of eIF4E (show EIF4E Proteins) into the processing bodies.
Hsp90 (show HSP90 Proteins) probably contributes to the correct localization of eIF4E (show EIF4E Proteins) and 4E-T to stress granules and also to the interaction between eIF4E (show EIF4E Proteins) and eIF4G (show EIF4G1 Proteins), both of which may be needed for eIF4E (show EIF4E Proteins) to acquire the physiological functionality
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic\; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene.
eukaryotic translation initiation factor 4E transporter
, eukaryotic translation initiation factor 4E nuclear import factor 1
, eukaryotic translation initiation factor 4E transporter-like
, eIF4E transporter