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mRNA-binding protein involved in translation elongation. Additionally we are shipping EIF5A2 Antibodies (63) and many more products for this protein.
Showing 10 out of 17 products:
Human EIF5A2 Protein expressed in Escherichia coli (E. coli) - ABIN667791
Tang, Dong, Ma, Xie, Chen, Fu, Lau, Li, Li, Guan: Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2010
Show all 2 references for ABIN667791
Human EIF5A2 Protein expressed in Escherichia coli (E. coli) - ABIN2006374
Jenkins, Hååg, Johansson: Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression. in Genomics 2001
Show all 2 references for ABIN2006374
eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells.
Data indicate that regulation of sonic hedgehog (SHh (show SHH Proteins))-GLI family zinc finger 1 (Gli1 (show GLI1 Proteins)) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression.
Data suggest that eukaryotic translation initiation factor 5A2 (EIF5A2) inhibitors might be considered as combination therapy to enhance chemosensitivity in patients with esophageal squamous cell carcinoma (ESCC).
Our findings indicate that EIF5A2 upregulation plays an important oncogenic role in gastric cancer. EIF5A2 may represent a new predictor for poor survival and is a potential therapeutic target for gastric cancer.
Increased expression of eIF5A2 increases metastasis and angiogenesis in esophageal squamous cell carcinoma via the HIF1alpha (show HIF1A Proteins)-mediated signaling pathway.
focus on updating current knowledge of the EIF5A2 gene in human cancers
EIF5A2 elevated TGF-beta1 (show TGFB1 Proteins) expression through STAT3 (show STAT3 Proteins) to induce epithelial-mesenchymal transition and promotes aggressiveness in bladder cancer.
It significantly inhibited activity of eIF5A2.
None of the latter died within 5 years in EIF5A2-negative staining group.
eIF-5A as well as the hypusine-forming enzymes deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH) are highly overexpressed in glioblastoma patient sample
activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
Eukaryotic initiation factor 5A (eIF5A) (eIF-4D (show EIF5A Proteins), eIF-5A (show EIF5A Proteins)) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys (show LYZ Proteins) 50. Mouse EIF5A1 (show EIF5A Proteins) and EIF5A2 encode two isoforms: eIF5AI (show EIF5A Proteins) and eIF5AII.
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
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