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mRNA-binding protein involved in translation elongation. Additionally we are shipping EIF5A2 Antibodies (69) and EIF5A2 Proteins (17) and many more products for this protein.
EIF5A2 overexpression may contribute to cancer progression and poor prognosis. Therefore, EIF5A2 could be a novel potential prognostic marker for Federation of Gynecology and Obstetrics (FIGO) stage I-II cervical cancer.
High EIF5A2 expression is associated with hepatocellular carcinoma.
MiR (show MLXIP ELISA Kits)-30b suppresses tumor migration and invasion by targeting EIF5A2 expression in gastric cancer cells.
eIF-5A2 plays an important role in doxorubicin chemoresistance in breast cancer cells.
Data indicate that regulation of sonic hedgehog (SHh (show SHH ELISA Kits))-GLI family zinc finger 1 (Gli1 (show GLI1 ELISA Kits)) signals to migration of pancreatic cancer AsPC-1 Cells through mediating eukaryotic translation initiation factor 5A (EIF5A2) gene expression.
Data suggest that eukaryotic translation initiation factor 5A2 (EIF5A2) inhibitors might be considered as combination therapy to enhance chemosensitivity in patients with esophageal squamous cell carcinoma (ESCC).
Our findings indicate that EIF5A2 upregulation plays an important oncogenic role in gastric cancer. EIF5A2 may represent a new predictor for poor survival and is a potential therapeutic target for gastric cancer.
Increased expression of eIF5A2 increases metastasis and angiogenesis in esophageal squamous cell carcinoma via the HIF1alpha (show HIF1A ELISA Kits)-mediated signaling pathway.
focus on updating current knowledge of the EIF5A2 gene in human cancers
EIF5A2 elevated TGF-beta1 (show TGFB1 ELISA Kits) expression through STAT3 (show STAT3 ELISA Kits) to induce epithelial-mesenchymal transition and promotes aggressiveness in bladder cancer.
activation of eIF-5A2 repressed p19 level and therefore destabilized p53 in transgenic mouse embryo fibroblast (MEF) cells. This subsequently allowed for the accumulation of chromosomal instability.
Eukaryotic initiation factor 5A (eIF5A) (eIF-4D (show EIF5A ELISA Kits), eIF-5A (show EIF5A ELISA Kits)) stimulates ribosomal peptidyltransferase activity, transport of HIV-1-mRNAs and binds exportins 1 and 4. Contains hypusine at lys (show LYZ ELISA Kits) 50. Mouse EIF5A1 (show EIF5A ELISA Kits) and EIF5A2 encode two isoforms: eIF5AI (show EIF5A ELISA Kits) and eIF5AII.
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).
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